STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
EphrinEphrin, isoform A; Ephrin receptor binding. It is involved in the biological process described with: peripheral nervous system development; melanotic encapsulation of foreign target; mushroom body development; axon guidance (652 aa)    
Predicted Functional Partners:
Eph
Protein tyrosine kinase activity; ephrin receptor activity; ATP binding; transmembrane receptor protein tyrosine kinase activity. It is involved in the biological process described with: axonogenesis; peripheral nervous system development; melanotic encapsulation of foreign target; protein phosphorylation; ephrin receptor signaling pathway; mushroom body development; signal transduction
   
 
 0.999
CG32000
Metal ion binding; nucleotide binding; ATPase activity, coupled to transmembrane movement of ions. It is involved in the biological process described with: cation transport
   
    0.978
CG31998
annotation not available
   
  
 0.977
Src64B
Tyrosine-protein kinase Src64B; Src oncogene at 64B is a Src family nonreceptor tyrosine kinase. It has many biological roles, including ring canal morphogenesis in oogenesis and the male germline, microfilament ring constriction during cellularization, and modulation of growth and apoptosis. Some of its roles overlap with those of Src42A
   
 0.959
PlexA
Plexin A, isoform A; Heparin binding; semaphorin receptor activity; protein binding; axon guidance receptor activity; 14-3-3 protein binding. It is involved in the biological process described with: motor neuron axon guidance; axon midline choice point recognition; semaphorin-plexin signaling pathway involved in regulation of photoreceptor cell axon guidance; axon guidance
   
  
 0.955
Rac1
Ras-related protein Rac1; Involved in axon outgrowth and myoblast fusion. Plays a role in regulating dorsal closure during embryogenesis. Involved in integrin alpha-PS3/beta-nu-mediated phagocytosis of Gram- positive S.aureus by hemocytes; Belongs to the small GTPase superfamily. Rho family
     
 0.942
rtGEF
Rho-type guanine exchange factor
     
 0.941
dock
Dreadlocks, isoform B; SH3/SH2 adaptor activity; protein binding; insulin receptor binding; cell adhesion molecule binding. It is involved in the biological process described with: myoblast fusion; axonogenesis; insulin receptor signaling pathway; negative regulation of insulin receptor signaling pathway; axon guidance
    
 0.937
Pak
P21-activated kinase, isoform F; PAK-kinase
     
 0.934
Cals
Calsyntenin-1; May modulate calcium-mediated postsynaptic signals
   
  
 0.914
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Drosophila melanogaster, fruit fly
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