STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Cooccurrence
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[Homology]
Score
gwProtein Gawky; Required for gene silencing mediated by micro-RNAs (miRNAs). Silences both polyadenylated and deadenylated mRNAs. Required for miRNA-mediated translational repression and mRNA decay. Not required for miRNA target recognition. Necessary to initiate but not to maintain silencing. Promotes mRNA deadenylation through the recruitment of the CCR4-NOT and PAN complexes and promotes decapping by the DCP1-DCP2 complex. Dissociates from silenced mRNAs after deadenylation. Required for completion of nuclear divisions during early embryonic development. Belongs to the GW182 family. (1384 aa)    
Predicted Functional Partners:
AGO1
Argonaute-1, isoform A; Argonaute-1 (AGO1) encodes an Argonaute/Piwi family protein, which interacts with microRNAs to form miRNA-induced silencing complexes (miRISCs). miRISCs are guided to target and repress mRNAs either by transcript destabilisation, translational inhibition, or both.
   
 0.999
pAbp
Polyadenylate-binding protein; Binds the poly(A) tail of mRNA. Since it interacts with the cap-associating translation initiation factor eIF4G, it is likely that it functions by linking Atx2 to the cap-binding complex. Forms a complex with tyf and Atx2 which functions in adult circadian pacemaker neurons to sustain circadian rhythms likely by switching between activator and repressor modes of post-transcriptional regulation via interaction with Lsm12a or me31B, respectively. The activator complex (Atx2-tyf activator complex) activates the TYF-dependent translation of per to maintain 24 [...]
   
 
 0.967
PAN2
PAN2-PAN3 deadenylation complex catalytic subunit PAN2; Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent [...]
   
 
 0.922
Gyf
Gigyf (Gyf) encodes a protein that is necessary for maintenance of neuromuscular homeostasis. It regulates protein translation, insulin/IGF signaling pathway and autophagy.
   
 
 0.911
Not1
Not1, isoform H; Not1 (Not1) encodes a poly(A)-specific ribonuclease involved in translation inhibition and ovarian follicle cell development.
   
 
 0.885
PAN3
PAN2-PAN3 deadenylation complex subunit PAN3; Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA deca [...]
   
 
 0.883
Dcr-2
Dicer-2, isoform A; Dicer-2 (Dcr-2) encodes a member of the RNase III family of double-stranded RNA-specific endonucleases. It acts in the RNAi pathway by cutting long dsRNA into siRNAs. It helps defend flies against viral infection, particularly RNA viruses. It also processes long, partially double-stranded endogenous transcripts (hairpin RNAs) into endo-siRNAs.
   
 0.879
AGO2
Protein argonaute-2; Essential for RNA interference (RNAi); double-stranded RNA induces potent and specific gene silencing. RNAi is mediated by the RNA-induced silencing complex (RISC), a sequence-specific, multicomponent nuclease that destroys or silences messenger RNAs homologous to the silencing trigger; Belongs to the argonaute family. Ago subfamily.
   
 0.840
Patr-1
Protein associated with topo II related - 1 (Patr-1) encodes a P body component involved in mRNA decapping and regulation of synaptic growth at neuromuscular junctions.
   
 
 0.840
Pop2
Pop2, isoform E; Pop2 (Pop2) encodes a poly(A)-specific ribonuclease involved in translation inhibition.
   
 
 0.828
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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