STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ChATCholine O-acetyltransferase 13 kDa chain; Choline acetyltransferase (ChAT) encodes a protein that catalyzes the biosynthesis of the neurotransmitter acetylcholine. It is considered to be a specific marker for cholinergic neurons. (721 aa)    
Predicted Functional Partners:
VAChT
Vesicular acetylcholine transporter (VAChT) encodes a vesicular transport protein necessary for packaging the neurotransmitter acetylcholine into synaptic vesicles; Belongs to the major facilitator superfamily. Vesicular transporter family.
 
 
  
 0.982
CG2818
LD22655p; Glycerophosphocholine phosphodiesterase activity; starch binding. It is involved in the biological process described with: glycerophospholipid catabolic process.
     
 0.905
CG2201
RE24176p; Choline kinase activity; ethanolamine kinase activity. It is involved in the biological process described with: phosphatidylcholine biosynthetic process; phosphatidylethanolamine biosynthetic process.
     
  0.900
VGlut
Vesicular glutamate transporter, isoform A.
   
  
 0.803
Mfe2
Peroxisomal Multifunctional enzyme type 2 (Mfe2) encodes a multifunctional protein harboring two separate enzyme activities: 2-enoyl-CoA hydratase 2 and 3-hydroxyacyl-CoA dehydrogenase. They function in the peroxisomal fatty acid breakdown spiral of beta-oxidation utilizing the (R)-isomer of the CoA-containing substrate; Belongs to the short-chain dehydrogenases/reductases (SDR) family.
   
 
 0.782
Gad1
Glutamic acid decarboxylase 1 (Gad1) encodes an essential, nervous system-specific glutamic acid decarboxylase, which is the synthetic enzyme for the major inhibitory neurotransmitter gamma-Aminobutyric acid (GABA). It is required for a multitude of physiological functions and adult behaviors dependent on GABA, including sleep, memory, circadian rhythms and egg hatching; Belongs to the group II decarboxylase family.
   
  
 0.745
colt
Congested-like trachea protein; Putative mitochondrial carrier of unknown solute specificity. Required for gas-filling of the tracheal system at hatching time of the embryo and for normal epithelial morphogenesis of the wings.
   
 
 0.728
Vmat
Vesicular monoamine transporter (Vmat) encodes a protein responsible for packaging the neurotransmitters dopamine, serotonin and octopamine into secretory vesicles.
 
 
  
 0.702
ChT
High-affinity choline transporter 1; Imports choline from the extracellular space to the neuron with high affinity. Rate-limiting step in acetylcholine synthesis. Sodium ion and chloride ion dependent (By similarity); Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
   
  
 0.699
Tdc2
Tyrosine decarboxylase activity; carboxy-lyase activity; pyridoxal phosphate binding. It is involved in the biological process described with: oviposition; locomotor rhythm; behavioral response to cocaine; cellular amino acid metabolic process; locomotory behavior.
      
 0.634
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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