STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Cyp12d1-dProbable cytochrome P450 12d1 distal, mitochondrial; Cyp12d1-d (Cyp12d1-d) encodes a protein involved in the response to the insecticide dichlorodiphenyltrichloroethane (DDT). (521 aa)    
Predicted Functional Partners:
Mdr65
Multidrug resistance protein homolog 65; Multi drug resistance 65 (Mdr65) encodes a member of the MRP/ABCC subfamily of ATP-binding cassette (ABC) transporters. It is involved in humoral/CNS barrier drug exclusion and response to insecticide; Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.
   
  
 0.607
Cyp6g1
Cytochrome P450 6g1; Necessary and sufficient for resistance to insecticides DDT and imidacloprid. May be involved in the metabolism of insect hormones.
  
 
0.558
CG2065
RH23455p; NADP-retinol dehydrogenase activity; Belongs to the short-chain dehydrogenases/reductases (SDR) family.
   
  
 0.553
Cyp6a2
Cytochrome P450 6a2; Is involved in the breakdown of synthetic insecticides and may be involved in the metabolism of insect hormones.
  
 
0.550
CG11322
SprT-like domain-containing protein.
      
 0.544
GstE1
Glutathione S transferase E1 (GstE1) encodes an enzyme involved in glutathione metabolic processes and response to heat.
      
 0.533
Lcp1
Larval cuticle protein 1; Component of the larval cuticle.
    
 
 0.526
rst
Irregular chiasm C-roughest protein; Roughest (rst) encodes a multi-purpose transmembrane protein that is well studied in the fly eye and muscle during development. It interacts with the transmembrane ligand encoded by hbs to guide cell movement.
      
 0.526
Cyp6a8
Cytochrome P450 6a8; Involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.
  
 
 
0.525
Cyp6d5
Probable cytochrome P450 6d5; May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.
  
 
0.520
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.