STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Zasp66Z band alternatively spliced PDZ-motif protein 66 (Zasp66) encodes a scaffold protein that binds the product of Actn and localizes to Z-discs in muscle cells. It plays a role in muscle development, especially in myofibril assembly. (430 aa)    
Predicted Functional Partners:
Zasp52
Z band alternatively spliced PDZ-motif protein 52 (Zasp52) encodes a member of the Zasp protein family. It is a scaffold protein that binds the product of Actn and localizes to muscle attachment sites and Z-discs in muscle cells, as well as localizing cortically in non-muscle cells. It plays a role in muscle development, especially in myofibril assembly.
   
 0.973
Zasp67
Z band alternatively spliced PDZ-motif protein 67 (Zasp67) encodes a member of the Zasp protein family. It is expressed during pupal development and plays a role in adult muscle development, especially in myofibril assembly.
    
 0.966
wupA
Wings up A (wupA) encodes a cytoskeletal protein of the troponin complex of the muscle thin filament. It is involved in calcium-dependent regulation of muscle contraction, and in development of the embryonic heart, skeletal muscle and flight muscle It also contributes to non-muscle functions such as apico-basal polarity formation, nuclear division and maintenance of nuclear integrity.
   
 
 0.840
Mf
Myofilin, isoform B; Myofilin (Mf) encodes a structural protein of muscular thick filaments, which may be needed for filament assembly. Alternative splicing of the gene, controlled by the product of salm, produces isoforms of varying size in thoracic muscles.
   
    0.836
CG43897
Uncharacterized protein, isoform M; Actin binding; muscle alpha-actinin binding. It is involved in the biological process described with: mesoderm development; muscle structure development; actin cytoskeleton organization.
   
 
 0.826
Mp20
Muscle-specific protein 20; It is involved in the biological process described with: myoblast fusion; regulation of myoblast fusion.
   
    0.735
sals
Sarcomere length short (sals) encodes an actin binding protein that promotes sarcomeric actin filament elongation from pointed ends during muscle growth.
   
 
 0.722
CG5023
GH21596p; Actin binding. It is involved in the biological process described with: actomyosin structure organization.
   
    0.720
CG1324
GH11587p.
      
 0.694
Tm2
Tropomyosin-2; Tropomyosin, in association with the troponin complex, plays a central role in the calcium dependent regulation of muscle contraction. May also regulate motor systems required to maintain nuclear integrity and apico-basal polarity during embryogenesis.
   
  
 0.687
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
Server load: medium (42%) [HD]