STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CG18004FI20187p1; It is involved in the biological process described with: chromatin remodeling. (297 aa)    
Predicted Functional Partners:
Arp5
Actin-related protein 5; Proposed core component of the chromatin remodeling Ino80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair.
    
 0.938
Rcd5
Reduction in Cnn dots 5 (Rcd5) encodes a protein that belongs to the family of forkhead-associated domain proteins. As part of the non-specific lethal complex, it regulates transcription of housekeeping genes by facilitating recruitment of RNA polymerase II to promoters. During mitosis it plays a key role in chromosomal-dependent microtubule assembly, centriole duplication and pericentriolar material maturation.
    
  0.894
CG11970
BcDNA.LD23876; Protease binding.
    
 0.894
CG32202
GEO10739p1; DNA binding. It is involved in the biological process described with: positive regulation of apoptotic process; apoptotic signaling pathway.
   
 0.859
CG12659
LD10749p; It is involved in the biological process described with: chromatin remodeling.
   
 0.844
Arp8
Actin-related protein 8; Plays an important role in the functional organization of mitotic chromosomes. Exhibits low basal ATPase activity, and unable to polymerize (By similarity); Belongs to the actin family. ARP8 subfamily.
   
 0.841
Bap55
Brahma associated protein 55kD (Bap55) encodes a member of two chromatin remodeling complexes. As part of the Brahma complex, it is needed for cell growth and survival in the wing imaginal disc; as a member of the TIP60 complex, it is thought to regulate dendrite wiring specificity in olfactory projection neurons; Belongs to the actin family.
   
  0.838
l(3)L1231
Lethal (3) L1231, isoform A; It is involved in the biological process described with: gravitaxis.
    
 0.838
CG10395
Uncharacterized protein, isoform D; It is involved in the biological process described with: ATP-dependent chromatin remodeling.
   
 0.834
pont
RuvB-like helicase 1; Acts as a transcriptional coactivator in Wg signaling caused by altered arm signaling. Pont and rept interfere antagonistically with nuclear arm signaling function, and are required to enhance or reduce arm activity, respectively. Also an essential cofactor for the normal function of Myc; required for cellular proliferation and growth.
   
  0.829
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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