STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
REPTOR-BPREPTOR-binding partner; Transcriptional regulator that acts in the TORC1 signaling pathway to regulate energy homeostasis and promote survival during nutrient deprivation. Interacts with REPTOR to form a transcriptional activator complex that functions downstream of TORC1 to up-regulate the expression of most target genes induced by TORC1 inhibition. In the complex, acts to enhance the binding of the transcriptional activator REPTOR to the regulatory sequences of target genes. Under normal conditions TORC1 is active, inhibiting the formation of the REPTOR/REPTOR-BP complex by phosphory [...] (118 aa)    
Predicted Functional Partners:
REPTOR
Protein CREBRF homolog; Transcriptional regulator that acts in the TORC1 signaling pathway to regulate energy homeostasis and promote survival during nutrient deprivation. Interacts with REPTOR to form a transcriptional activator complex that functions downstream of TORC1 to up-regulate the expression of most target genes induced by TORC1 inhibition. In the complex, acts as the transcriptional activator. Under normal conditions TORC1 is active, inhibiting the formation of the REPTOR/REPTOR-BP complex by phosphorylating REPTOR and mediates its cytoplasmic retention by forming a docking [...]
  
 
 0.971
CG16721
LD23868p; It is involved in the biological process described with: cAMP-mediated signaling; signal transduction.
   
  
 0.673
CG4282
LD21421p; DNA-binding transcription factor activity; zinc ion binding; transcription regulatory region sequence-specific DNA binding. It is involved in the biological process described with: regulation of gene expression; regulation of transcription, DNA-templated.
    
   0.667
CG5885
LD05267p; It is involved in the biological process described with: SRP-dependent cotranslational protein targeting to membrane.
 
      0.616
CG11658
LD30288p; It is involved in the biological process described with: SCF-dependent proteasomal ubiquitin-dependent protein catabolic process.
    
 
 0.613
CG3224
Zinc finger protein 593 homolog; Nucleic acid binding; zinc ion binding; ribosomal large subunit binding. It is involved in the biological process described with: ribosomal large subunit export from nucleus; Belongs to the ZNF593/BUD20 C2H2-type zinc-finger protein family.
   
  
 0.607
unk
Unkempt (unk) encodes a highly conserved protein with roles in mRNA binding and ubiquitination. Together with the product of hdc, it acts downstream of the product of Mtor to regulate photoreceptor differentiation during eye development.
      
 0.607
CG6770
RH17958p; It is involved in the biological process described with: negative regulation of cell cycle; negative regulation of cell population proliferation; regulation of transcription by RNA polymerase II.
   
  
 0.571
thoc7
THO complex protein 7; The THO complex is required for cell proliferation and for proper export of heat-shock mRNAs under heat stress. Belongs to the THOC7 family.
   
   0.514
alpha-Est3
Alpha-Esterase-3, isoform A; Carboxylic ester hydrolase activity.
      
 0.493
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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