STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
JhI-21Juvenile hormone Inducible-21, isoform A; L-amino acid transmembrane transporter activity. It is involved in the biological process described with: cellular response to leucine; defense response to fungus; L-leucine import across plasma membrane; positive regulation of insulin secretion; carbohydrate homeostasis. (500 aa)    
Predicted Functional Partners:
CD98hc
CD98 heavy chain (CD98hc) encodes a transporter involved in the transmembrane import of L-leucine.
   
 0.972
mnd
Minidiscs, isoform A; Minidiscs (mnd) encodes the putative amino acid/polyamine transporter involved in leucine import. It is expressed in the larval fat body and is required for the differentiation of the wing imaginal disc cells.
  
 
0.912
gb
Genderblind, isoform A; Genderblind (gb) encodes an amino acid transporter involved in glutamate secretion into the extracellular space. It regulates synaptic transmission and male courtship behavior by altering glutamate receptor abundance in the nervous system.
  
 
0.906
Eaat1
Excitatory amino acid transporter 1 (Eaat1) encodes a transmembrane protein with a glutamate:sodium symporter activity. It is regulated by Notch signalling and contributes to larval locomotion and lifespan.
  
  
 0.715
Eaat2
Excitatory amino acid transporter 2 (Eaat2) encodes a transmembrane protein involved in aspartate and taurine transport.
  
  
 0.713
CG13384
Uncharacterized protein, isoform C; Amino acid transmembrane transporter activity. It is involved in the biological process described with: amino acid transmembrane transport.
   
  
 0.559
CG5535
Uncharacterized protein, isoform C; L-ornithine transmembrane transporter activity; amino acid transmembrane transporter activity; L-lysine transmembrane transporter activity; arginine transmembrane transporter activity. It is involved in the biological process described with: amino acid transmembrane transport; L-ornithine transmembrane transport; amino acid transport; L-arginine import across plasma membrane.
  
 
0.531
CG34138
IP17336p.
      
 0.523
path
Proton-coupled amino acid transporter-like protein pathetic; Amino acid transporter which has pH-dependent electrogenic transport activity for alanine and glycine but not for proline. Plays a role in positive regulation of growth by directly or indirectly modulating the effects of the TOR signaling pathway. Required in a cell- autonomous manner for dendrite growth in neurons with large dendrite arbors.
   
  
 0.516
Gdh
Glutamate dehydrogenase, mitochondrial; Glutamate dehydrogenase (Gdh) encodes a glutamate dehydrogenase involved glutamate metabolism.
  
  
 0.502
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.