node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Alg3 | CG5504 | FBpp0072004 | FBpp0088955 | Lethal(2)neighbour of tid protein; dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase activity. It is involved in the biological process described with: protein glycosylation. | Protein tumorous imaginal discs, mitochondrial; May act as a tumor suppressor in larval imaginal disks. | 0.842 |
Alg3 | l(2)dtl | FBpp0072004 | FBpp0071994 | Lethal(2)neighbour of tid protein; dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase activity. It is involved in the biological process described with: protein glycosylation. | Protein lethal(2)denticleless; Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control. The DCX(DTL) complex, also named CRL4(CDT2) complex, mediates the polyubiquitination and subsequent degradation of E2f during S phase. E2f degradation is necessary to ensure proper development. Substrates require their interaction with PCNA for their polyubiquitination: substrates interact with PCNA via their PIP-box, leading to recruit the DCX(DTL) complex; Belongs to the WD repeat cdt2 family. | 0.433 |
CG11779 | CG5504 | FBpp0083163 | FBpp0088955 | Mitochondrial import inner membrane translocase subunit TIM44; Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner; Belongs to the Tim44 family. | Protein tumorous imaginal discs, mitochondrial; May act as a tumor suppressor in larval imaginal disks. | 0.599 |
CG11779 | CG7394 | FBpp0083163 | FBpp0288463 | Mitochondrial import inner membrane translocase subunit TIM44; Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner; Belongs to the Tim44 family. | Mitochondrial import inner membrane translocase subunit TIM14; Probable component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. May act as a co-chaperone that stimulate the ATP-dependent activity (By similarity). | 0.873 |
CG11779 | Hsc70-5 | FBpp0083163 | FBpp0086694 | Mitochondrial import inner membrane translocase subunit TIM44; Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner; Belongs to the Tim44 family. | Heat shock 70 kDa protein cognate 5. | 0.989 |
CG11779 | Hsc70Cb | FBpp0083163 | FBpp0292999 | Mitochondrial import inner membrane translocase subunit TIM44; Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner; Belongs to the Tim44 family. | Hsc70Cb, isoform G; Hsc70Cb (Hsc70Cb) encodes an HSP110 family protein that interacts physically with the product of DnaJ-1 as a chaperone of misfolded proteins. It functions together with the product of DnaJ-1 to prevent the toxicity of aggregation-prone proteins. | 0.629 |
CG11779 | Roe1 | FBpp0083163 | FBpp0086795 | Mitochondrial import inner membrane translocase subunit TIM44; Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner; Belongs to the Tim44 family. | GrpE protein homolog, mitochondrial; Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Seems to control the nucleotide-dependent binding of mitochondrial HSP70 to substrate proteins (By similarity). | 0.983 |
CG11779 | Trap1 | FBpp0083163 | FBpp0085482 | Mitochondrial import inner membrane translocase subunit TIM44; Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner; Belongs to the Tim44 family. | Trap1, isoform A; Trap1 (Trap1) encodes a mitochondrial chaperone protein of the heat shock protein (HSP90) family. It shows an ATPase activity and is involved in neurodegeneration associated with mitochondrial dysfunction. | 0.408 |
CG2794 | CG5504 | FBpp0077727 | FBpp0088955 | PfkB domain-containing protein; Hydrolase activity, acting on glycosyl bonds; phosphotransferase activity, alcohol group as acceptor. | Protein tumorous imaginal discs, mitochondrial; May act as a tumor suppressor in larval imaginal disks. | 0.638 |
CG5504 | Alg3 | FBpp0088955 | FBpp0072004 | Protein tumorous imaginal discs, mitochondrial; May act as a tumor suppressor in larval imaginal disks. | Lethal(2)neighbour of tid protein; dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase activity. It is involved in the biological process described with: protein glycosylation. | 0.842 |
CG5504 | CG11779 | FBpp0088955 | FBpp0083163 | Protein tumorous imaginal discs, mitochondrial; May act as a tumor suppressor in larval imaginal disks. | Mitochondrial import inner membrane translocase subunit TIM44; Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner; Belongs to the Tim44 family. | 0.599 |
CG5504 | CG2794 | FBpp0088955 | FBpp0077727 | Protein tumorous imaginal discs, mitochondrial; May act as a tumor suppressor in larval imaginal disks. | PfkB domain-containing protein; Hydrolase activity, acting on glycosyl bonds; phosphotransferase activity, alcohol group as acceptor. | 0.638 |
CG5504 | CG7394 | FBpp0088955 | FBpp0288463 | Protein tumorous imaginal discs, mitochondrial; May act as a tumor suppressor in larval imaginal disks. | Mitochondrial import inner membrane translocase subunit TIM14; Probable component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. May act as a co-chaperone that stimulate the ATP-dependent activity (By similarity). | 0.712 |
CG5504 | Hsc70-5 | FBpp0088955 | FBpp0086694 | Protein tumorous imaginal discs, mitochondrial; May act as a tumor suppressor in larval imaginal disks. | Heat shock 70 kDa protein cognate 5. | 0.909 |
CG5504 | Hsc70Cb | FBpp0088955 | FBpp0292999 | Protein tumorous imaginal discs, mitochondrial; May act as a tumor suppressor in larval imaginal disks. | Hsc70Cb, isoform G; Hsc70Cb (Hsc70Cb) encodes an HSP110 family protein that interacts physically with the product of DnaJ-1 as a chaperone of misfolded proteins. It functions together with the product of DnaJ-1 to prevent the toxicity of aggregation-prone proteins. | 0.787 |
CG5504 | Roe1 | FBpp0088955 | FBpp0086795 | Protein tumorous imaginal discs, mitochondrial; May act as a tumor suppressor in larval imaginal disks. | GrpE protein homolog, mitochondrial; Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Seems to control the nucleotide-dependent binding of mitochondrial HSP70 to substrate proteins (By similarity). | 0.850 |
CG5504 | Sil1 | FBpp0088955 | FBpp0084244 | Protein tumorous imaginal discs, mitochondrial; May act as a tumor suppressor in larval imaginal disks. | Nucleotide exchange factor Sil1; Required for protein translocation and folding in the endoplasmic reticulum (ER). Functions as a nucleotide exchange factor for an ER lumenal chaperone of HSP70 family (By similarity). Belongs to the SIL1 family. | 0.616 |
CG5504 | Trap1 | FBpp0088955 | FBpp0085482 | Protein tumorous imaginal discs, mitochondrial; May act as a tumor suppressor in larval imaginal disks. | Trap1, isoform A; Trap1 (Trap1) encodes a mitochondrial chaperone protein of the heat shock protein (HSP90) family. It shows an ATPase activity and is involved in neurodegeneration associated with mitochondrial dysfunction. | 0.702 |
CG5504 | l(2)dtl | FBpp0088955 | FBpp0071994 | Protein tumorous imaginal discs, mitochondrial; May act as a tumor suppressor in larval imaginal disks. | Protein lethal(2)denticleless; Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control. The DCX(DTL) complex, also named CRL4(CDT2) complex, mediates the polyubiquitination and subsequent degradation of E2f during S phase. E2f degradation is necessary to ensure proper development. Substrates require their interaction with PCNA for their polyubiquitination: substrates interact with PCNA via their PIP-box, leading to recruit the DCX(DTL) complex; Belongs to the WD repeat cdt2 family. | 0.626 |
CG7394 | CG11779 | FBpp0288463 | FBpp0083163 | Mitochondrial import inner membrane translocase subunit TIM14; Probable component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. May act as a co-chaperone that stimulate the ATP-dependent activity (By similarity). | Mitochondrial import inner membrane translocase subunit TIM44; Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner; Belongs to the Tim44 family. | 0.873 |