STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
smidSmallminded, isoform A; Preribosome binding; ATPase activity; ATP binding. It is involved in the biological process described with: positive regulation of telomerase activity; ribosome biogenesis. (944 aa)    
Predicted Functional Partners:
Mtr4
Mtr4 helicase (Mtr4) encodes an RNA helicase involved in the viral defense response.
   
 
 0.953
CG4806
LD27920p; RNA binding; mRNA binding.
   
  
 0.940
CG1234
Nucleolar complex protein 3 homolog; Chromatin binding.
   
  
 0.924
Ns1
Guanine nucleotide-binding protein-like 3 homolog; Nucleostemin 1 (Ns1) encodes a GTPase that is enriched in the peripheral granular components of nucleoli of most larval and adult cells. It is required for nucleolar release of the large ribosomal subunit. Depletion of the Ns1 product reduces viability of midgut imaginal island cells and ribosome abundance in polyploid cells; Belongs to the TRAFAC class YlqF/YawG GTPase family.
   
 
 0.907
CG5033
Ribosome biogenesis protein BOP1 homolog; Required for maturation of ribosomal RNAs and formation of the large ribosomal subunit; Belongs to the WD repeat BOP1/ERB1 family.
   
 
 0.906
Hlc
Helicase, isoform A; ATP binding; RNA helicase activity; RNA binding.
   
 
 0.889
CG9004
Nucleolar MIF4G domain-containing protein 1 homolog; RNA binding. It is involved in the biological process described with: ribosomal small subunit biogenesis.
   
    0.888
Ns2
Nucleolar GTP-binding protein 2; GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation. Belongs to the TRAFAC class YlqF/YawG GTPase family. NOG2 subfamily.
   
 
 0.883
Non1
Nucleolar GTP-binding protein 1; Involved in the biogenesis of the 60S ribosomal subunit (By similarity). Required for normal assembly of the mitotic spindle. May be involved in both centrosome-dependent and centrosome-independent spindle assembly programs. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily.
   
 
 0.869
CG8064
GH01043p; snoRNA binding. It is involved in the biological process described with: maturation of SSU-rRNA.
   
  
 0.863
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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