STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Ance-3Angiotensin-converting enzyme; Peptidyl-dipeptidase activity; metallopeptidase activity. It is involved in the biological process described with: proteolysis. (844 aa)    
Predicted Functional Partners:
Nep4
Neprilysin-4; Metalloendoprotease which cleaves peptides at the amino side of hydrophobic residues - such as the hormones Akh and Dh31, and the neuropeptides Allatostatins (AST1, AST2, AST3 and AST4), Crz, Drosulfakinins (DSK-I and DSK-II), Lk, sNPF and the tachykinin peptides TK-1, TK-2, TK-4 and TK-5. Functions in female fertility, memory formation and may also act in regulating insulin signaling and food intake. Likely to be involved in controlling feeding behavior and the expression of insulin-like peptides by cleaving various regulatory peptides that include certain Drosulfakinins [...]
   
  
 0.858
Nep3
Neprilysin-3; Metalloendoprotease which is required in the dorsal paired medial neurons for the proper formation of long-term (LTM) and middle- term memories (MTM). Also required in the mushroom body neurons where it functions redundantly with neprilysins Nep2 and Nep4 in normal LTM formation; Belongs to the peptidase M13 family.
      
 0.855
Nep2
Neprilysin-2, soluble form; Metalloendoprotease which cleaves peptides such as tachykinin peptide TK-2 at the amino side of hydrophobic residues. Functions in female fertility, embryogenesis and memory formation. Required in females for normal patterns of egg laying, probably due to its function in sperm retention and preventing sperm displacement by rival ejaculates. Also required for normal patterns of hatching due to its important role in early embryonic development. Required in the dorsal paired medial neurons for the proper formation of middle-term memory. Also required in the mus [...]
      
 0.847
Nep1
Neprilysin-1; Metalloendoprotease which functions in fertility and memory formation. Required in the dorsal paired medial neurons and alpha/beta mushroom body neurons for the proper formation of long-term and middle-term memories. Required in males to maximise egg-laying in female mates and is also required in females for their fertility ; Belongs to the peptidase M13 family.
      
 0.844
Nepl12
Neprilysin-like 12; Metalloendopeptidase activity. It is involved in the biological process described with: proteolysis.
   
  
 0.841
Nepl20
Neprilysin-like 20; Metalloendopeptidase activity. It is involved in the biological process described with: proteolysis.
      
 0.841
Nep6
Neprilysin 6, isoform A; Metalloendopeptidase activity. It is involved in the biological process described with: proteolysis.
   
  
 0.837
CG10137
GH24474p.
 
      0.788
Ide
Insulin-degrading enzyme; Insulin degrading metalloproteinase (Ide) encodes a metalloprotease that controls growth in a cell-autonomous manner by regulating the level of the insulin-like peptide encoded by Ilp2.
      
 0.672
Tace
ADAM 17-like protease; Tace (Tace) encodes a transmembrane anchored, cell surface metalloprotease and member of the ADAM family of proteins. The product of Tace, along with the related ADAM protease encoded by kuz, performs ectodomain shedding by cleaving cell surface receptors and/or ligands to affect cell-cell signaling or adhesion. Both proteases are implicated in the Notch signaling pathway.
   
  
 0.596
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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