STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Gene Fusion
Cooccurrence
Coexpression
Experiments
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[Homology]
Score
Dyrk3Putative dual specificity tyrosine-phosphorylation-regulated kinase 3 homolog; ATP binding; protein serine/threonine kinase activity. It is involved in the biological process described with: peptidyl-threonine phosphorylation; peptidyl-serine phosphorylation; Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily. (828 aa)    
Predicted Functional Partners:
wap
Wings apart (wap) encodes a protein required for growth, viability, muscle development, and proper wing venation. It physically interacts with the product of ds, and functions in the Hippo pathway to regulate growth.
   
 
 0.821
tefu
Serine/threonine-protein kinase ATM; Serine/threonine-protein kinase which recognizes the substrate consensus sequence [ST]-Q. Required to suppress spontaneous apoptosis of proliferating cells during development, and for their proper differentiation. Required for female fertility. Protects telomeres from fusion, maybe by recruiting or maintaining chromatin- modifying complexes such as Su(var)205/HP1. May activate checkpoint signaling in response to DNA double-stranded breaks induced by low-dose ionizing radiation. May phosphorylate histone H2AV. Belongs to the PI3/PI4-kinase family. AT [...]
    
  0.757
polo
Serine/threonine-protein kinase polo; May play a role in regulating both nuclear and cytoplasmic aspects of the mitotic cycle. Regulates localization of the augmin complex during mitosis by ensuring its location on mitotic spindles. Also regulates augmin complex localization during male meiosis by promoting its placement at kinetochores while preventing its association with spindle microtubules ; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily.
    
 
0.754
p53
P53 protein long form variant 1; P53 (p53) encodes a transcriptional factor required for adaptive responses to genotoxic stress, including cell death, compensatory proliferation and DNA repair.
     
  0.750
cdi
Center divider (cdi) encodes a serine/threonine kinase that stimulates the formation of actin fibers and focal adhesions through phosphorylation of the F-actin depolimerization factor tsr.
  
 
 0.721
SAK
Serine/threonine-protein kinase PLK4; Serine/threonine-protein kinase that plays a central role in centriole duplication. Able to trigger procentriole formation on the surface of the mother centriole cylinder, using mother centriole as a platform, leading to the recruitment of centriole biogenesis proteins such as Sas-6. When overexpressed, it is able to induce centrosome amplification through the simultaneous generation of multiple procentrioles adjoining each parental centriole during S phase. Centrosome amplification following overexpression can initiate tumorigenesis, highlighting [...]
   
 
0.691
CG10508
Uncharacterized protein, isoform K.
      
 0.631
Cadps
Calcium-dependent secretion activator; Calcium-binding protein involved in exocytosis of vesicles filled with neurotransmitters and neuropeptides. May specifically mediate the Ca(2+)-dependent exocytosis of large dense-core vesicles (DCVs) and other dense-core vesicles. However, it probably also participates in small clear synaptic vesicles (SVs) exocytosis and it is unclear whether its function is related to Ca(2+) triggering.
      
 0.597
trc
Serine/threonine-protein kinase tricorner; Has an important role, with fry, in controlling cell structure and proliferation of a variety of polarized outgrowths including epidermal hairs, bristles, arista laterals, and dendrites. Affects cellular morphogenesis by regulating the expression of target genes that encode cytoskeleton-interacting proteins and not via the direct modification of the cytoskeleton. Maintains the integrity of epidermal hairs and is an essential component of the signaling pathway regulating dendritic branching of sensory neurons. Belongs to the protein kinase supe [...]
    
 
0.546
Mrtf
Myocardin-related transcription factor (Mrtf) encodes a protein that binds to the product of bs, and likely other transcription factors, to enhance downstream gene activation. The activity of the product of Mrtf is regulated by free actin levels. It contributes to tracheal branching, border cell migration, and other cell stretching and invasive migration processes during development.
    
 
 0.546
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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