STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Fucaalpha-L-fucosidase (Fuca) encodes an enzyme belonging to the family of hydrolases. It has also been identified as a transmembrane protein in the plasma-membrane of spermatozoa. Its roles include N-glycan degradation, glycan structure degradation, and is potentially involved in fertilization, particularly in initial sperm-egg recognition; Belongs to the glycosyl hydrolase 29 family. (494 aa)    
Predicted Functional Partners:
O-fut2
GDP-fucose protein O-fucosyltransferase 2; Catalyzes the reaction that attaches fucose through an O- glycosidic linkage to a conserved serine or threonine residue in the consensus sequence C1-X(2,3)-S/T-C2-X(2)-G of thrombospondin type 1 repeats where C1 and C2 are the first and second cysteines, respectively. O-fucosylates members of a number of protein families including the ADAMTS family, the thrombosporin (TSP) and spondin families.
      
 0.750
CG4557
FI19713p1; Rab GTPase binding.
      
 0.660
Gpdh2
Protein homodimerization activity; glycerol-3-phosphate dehydrogenase [NAD+] activity; NAD binding. It is involved in the biological process described with: carbohydrate metabolic process; NADH oxidation; glycerol-3-phosphate metabolic process; glycerol-3-phosphate catabolic process.
      
 0.609
FucTA
Glycoprotein 3-alpha-L-fucosyltransferase A; Alpha1,3-fucosyltransferase A (FucTA) encodes a Golgi fucosyltransferase that transfers fucose in alpha1,3-linkage to core N-acetylglucosamine residues of N-linked oligosaccharides. It is required for the synthesis of the anti-horseradish peroxidase epitope; Belongs to the glycosyltransferase 10 family.
      
 0.584
Gal
Beta galactosidase (Gal) encodes a putative digestive enzyme that hydrolyses beta-galactosides into monosaccharides. Gal is highly expressed and enriched in the midgut, an organ involved in digestion; Belongs to the glycosyl hydrolase 35 family.
 
  
 0.572
Ect3
Beta-galactosidase activity. It is involved in the biological process described with: carbohydrate metabolic process.
 
  
 0.541
Ak2
Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways; Belongs to the adenylate kinase family. AK2 subfamily.
      
 0.537
CG9109
Uncharacterized protein, isoform C; Acetylglucosaminyltransferase activity.
      
 0.537
C1GalTA
Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1; Core 1 Galactosyltransferase A (C1GalTA) encodes a protein that exhibits strong core 1beta1,3GalT activity, and is involved in the synthesis of T antigen in hemocytes. Its roles include hematopoietic stem cell maintenance, neural network and neuromuscular junction formation.
      
 0.528
CG3726
Uncharacterized protein, isoform B; DNA binding. It is involved in the biological process described with: regulation of transcription by RNA polymerase II.
      
 0.512
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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