STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
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[Homology]
Score
Prx5Peroxiredoxin 5, isoform A; Antioxidant activity; oxidoreductase activity. It is involved in the biological process described with: negative regulation of innate immune response; response to oxidative stress; determination of adult lifespan; negative regulation of apoptotic process; cell redox homeostasis (190 aa)    
Predicted Functional Partners:
Prx3
Thioredoxin peroxidase 3; Peroxidase activity; antioxidant activity; thioredoxin peroxidase activity. It is involved in the biological process described with: phagocytosis; oxidation-reduction process; determination of adult lifespan; negative regulation of apoptotic process; cell redox homeostasis; hydrogen peroxide catabolic process
   
 0.992
Trx-2
Thioredoxin-2, isoform A; Thioredoxin-2; Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions. As a reducing substrate of peroxiredoxin 1, thioredoxin 2 is preferred over thioredoxin 1
   
 0.982
CG33276
Ubiquitin-related modifier 1 homolog; Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2- thiolation reaction by being thiocarboxylated (-COSH) at its C- terminus by MOCS3. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins. The thiocarboxylated form serves as substrate for conjugation and oxidative stress sp [...]
    
 
 0.975
CG8993
GEO01508p1; Disulfide oxidoreductase activity; protein disulfide oxidoreductase activity. It is involved in the biological process described with: cellular response to DNA damage stimulus; cell redox homeostasis; glycerol ether metabolic process
   
 0.969
Sod2
Superoxide dismutase [Mn], mitochondrial; Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems
   
 
 0.957
Jafrac2
Thioredoxin peroxidase 2, isoform A; Protein binding; peroxidase activity; antioxidant activity; thioredoxin peroxidase activity. It is involved in the biological process described with: response to oxidative stress; positive regulation of JAK-STAT cascade; oxidation-reduction process; cellular response to DNA damage stimulus; positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway; apoptotic signaling pathway; cellular response to cold; hydrogen peroxide catabolic process; defense response to bacterium
   
 
 0.953
Jafrac1
Peroxiredoxin 1; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2) (By similarity). Reduces an intramolecular disulfide bond in GDPD5 that gates the ability to GDPD5 to drive postmitotic motor neuron diffe [...]
   
 0.949
CG13090
Adenylyltransferase and sulfurtransferase MOCS3; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Also essential during biosynthesis of the molybdenum cofactor. Acts by mediating the C-terminal thiocarboxylation of sulfur carriers URM1 and MOCS2A. Its N-terminus first activates URM1 and MOCS2A as acyl-adenylates (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to URM1 and MOCS2A to form thiocarboxylation (-COSH) of their C-terminus. The reaction probably involves hydrogen sulfide t [...]
   
  
 0.898
CG6888
Uncharacterized protein; AT16346p; Thioredoxin peroxidase activity. It is involved in the biological process described with: oxidation-reduction process; cellular response to DNA damage stimulus
   
 0.876
Prx6005
Peroxiredoxin 6005; Peroxidase activity; glutathione peroxidase activity; antioxidant activity; thioredoxin peroxidase activity. It is involved in the biological process described with: oxidation-reduction process; cell redox homeostasis; hydrogen peroxide catabolic process
   
 
 0.866
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, fruit fly
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