STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
stmAProtein EFR3 homolog cmp44E; An essential gene required for embryogenesis; required for cell viability; Belongs to the EFR3 family. (834 aa)    
Predicted Functional Partners:
Ttc7
Tetratricopeptide repeat domain 7, isoform A; It is involved in the biological process described with: phosphatidylinositol phosphorylation; protein localization to plasma membrane.
   
 
 0.985
Pi4KIIIalpha
Phosphatidylinositol 4-kinase III alpha (PI4KIIIalpha) encodes a lipid kinase that synthesizes phosphatidylinositol 4-phosphate from phosphatidylinositol. Its roles include localization of plasma membrane-associated cytoskeletal and membrane trafficking proteins, Hippo signaling regulation and polarization of developing oocytes; Belongs to the PI3/PI4-kinase family.
   
 
 0.937
Hyccin
Hyccin, isoform A; It is involved in the biological process described with: protein localization to plasma membrane; phosphatidylinositol phosphorylation.
   
  
 0.898
RpS3A
Ribosomal protein S3A (RpS3A) encodes an essential component of the small ribosomal subunit that functions in protein synthesis. It is classified as a 'Minute' gene as heterozygous mutants exhibit a slower developmental rate and small adult bristles; Belongs to the eukaryotic ribosomal protein eS1 family.
    
 
 0.648
mrt
Martik, isoform A; Transcription regulatory region sequence-specific DNA binding. It is involved in the biological process described with: gene silencing; regulation of chromatin organization.
   
  
 0.631
sktl
Skittles, isoform A; Skittles (sktl) encodes the major Phosphatidylinositol 4-Phosphate-5 kinase (PI4P5K), catalysing the formation of phosphoinositol-4,5-bisphosphate (PIP4,5). The sktl product is involved in many cellular processes involving (PIP4,5), such as endocytosis. It plays an important role in cell polarity by controlling the localization of the product encoded by baz.
   
 
 0.600
fwd
Four wheel drive (fwd) encodes a Golgi-localized lipid kinase that synthesizes phosphatidylinositol 4-phosphate from phosphatidylinositol. It is involved in spermatocyte cytokinesis and male fertility; Belongs to the PI3/PI4-kinase family.
   
  
 0.591
CG8379
LD33793p.
   
  
 0.553
Sac1
Sac1 phosphatase (Sac1) encodes a lipid phosphatase that dephosphorylates phosphatidylinositol 4-phosphate to generate phosphatidylinositol. It is involved in dorsal closure, Hedgehog signaling and axon guidance.
   
  
 0.432
Osbp
Oxysterol binding protein (Osbp) encodes a protein important for sperm development; Belongs to the OSBP family.
   
  
 0.430
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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