node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Atg5 | CG17140 | FBpp0071023 | FBpp0100169 | Autophagy protein 5; Involved in autophagic vesicle formation. Conjugation with Atg12, through a ubiquitin-like conjugating system involving Atg7 as an E1-like activating enzyme and Atg10 as an E2-like conjugating enzyme, is essential for its function. The Atg12-Atg5 conjugate acts as an E3- like enzyme which is required for lipidation of Atg8 and its association to the vesicle membranes (By similarity). | MIP04751p; Voltage-gated anion channel activity; channel activity. It is involved in the biological process described with: anion transmembrane transport. | 0.608 |
Atg5 | Marf | FBpp0071023 | FBpp0310030 | Autophagy protein 5; Involved in autophagic vesicle formation. Conjugation with Atg12, through a ubiquitin-like conjugating system involving Atg7 as an E1-like activating enzyme and Atg10 as an E2-like conjugating enzyme, is essential for its function. The Atg12-Atg5 conjugate acts as an E3- like enzyme which is required for lipidation of Atg8 and its association to the vesicle membranes (By similarity). | Transmembrane GTPase Marf; Mitochondrial assembly regulatory factor (Marf) encodes a dynamin-family GTPase that mediates outer mitochondrial membrane tethering and fusion. Marf loss causes mitochondrial fragmentation and endoplasmic reticular stress that evoke skeletal muscle, retinal and heart tube dysfunction; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. Mitofusin subfamily. | 0.827 |
Atg5 | Pink1 | FBpp0071023 | FBpp0099833 | Autophagy protein 5; Involved in autophagic vesicle formation. Conjugation with Atg12, through a ubiquitin-like conjugating system involving Atg7 as an E1-like activating enzyme and Atg10 as an E2-like conjugating enzyme, is essential for its function. The Atg12-Atg5 conjugate acts as an E3- like enzyme which is required for lipidation of Atg8 and its association to the vesicle membranes (By similarity). | PTEN-induced putative kinase 1 (Pink1) is the ortholog of human PINK1, a gene mutated in autosomal recessive Parkinson's disease. Pink1 encodes a mitochondrially targeted Ser-Thr kinase. It has been linked to a number of cellular functions including altering mitochondrial dynamics, the autophagic degradation of dysfunctional mitochondria, and the proper function of Complex I of the electron transport chain. | 0.933 |
Atg5 | Porin2 | FBpp0071023 | FBpp0079773 | Autophagy protein 5; Involved in autophagic vesicle formation. Conjugation with Atg12, through a ubiquitin-like conjugating system involving Atg7 as an E1-like activating enzyme and Atg10 as an E2-like conjugating enzyme, is essential for its function. The Atg12-Atg5 conjugate acts as an E3- like enzyme which is required for lipidation of Atg8 and its association to the vesicle membranes (By similarity). | Voltage-dependent anion-selective channel protein 2; Porin2 (Porin2) encodes a protein with voltage-independent cation-selective pore activity that is involved in ion transport. | 0.608 |
Atg5 | Tom20 | FBpp0071023 | FBpp0304965 | Autophagy protein 5; Involved in autophagic vesicle formation. Conjugation with Atg12, through a ubiquitin-like conjugating system involving Atg7 as an E1-like activating enzyme and Atg10 as an E2-like conjugating enzyme, is essential for its function. The Atg12-Atg5 conjugate acts as an E3- like enzyme which is required for lipidation of Atg8 and its association to the vesicle membranes (By similarity). | Translocase of outer membrane 20, isoform A; Mitochondrion targeting sequence binding; P-P-bond-hydrolysis-driven protein transmembrane transporter activity. It is involved in the biological process described with: protein targeting to mitochondrion; tRNA import into mitochondrion; mitochondrial outer membrane translocase complex assembly; protein import into mitochondrial matrix. | 0.575 |
Atg5 | fzo | FBpp0071023 | FBpp0083791 | Autophagy protein 5; Involved in autophagic vesicle formation. Conjugation with Atg12, through a ubiquitin-like conjugating system involving Atg7 as an E1-like activating enzyme and Atg10 as an E2-like conjugating enzyme, is essential for its function. The Atg12-Atg5 conjugate acts as an E3- like enzyme which is required for lipidation of Atg8 and its association to the vesicle membranes (By similarity). | Transmembrane GTPase fzo; Essential transmembrane GTPase, which mediates mitochondrial fusion during spermatogenesis. In early spermatocytes, fusion of mitochondria give rise to two organelles named Nebenkern and constitutes an important step in mitochondria morphology, which is balanced between fusion and fission. Essential for fertility. | 0.794 |
Atg5 | park | FBpp0071023 | FBpp0077974 | Autophagy protein 5; Involved in autophagic vesicle formation. Conjugation with Atg12, through a ubiquitin-like conjugating system involving Atg7 as an E1-like activating enzyme and Atg10 as an E2-like conjugating enzyme, is essential for its function. The Atg12-Atg5 conjugate acts as an E3- like enzyme which is required for lipidation of Atg8 and its association to the vesicle membranes (By similarity). | Parkin (park) encodes an E3 ubiquitin ligase with a key role in protein ubiquitination. It is involved in mitochondrion organization, oxidative stress and locomotion; Belongs to the RBR family. Parkin subfamily. | 0.835 |
Atg5 | ref(2)P | FBpp0071023 | FBpp0099683 | Autophagy protein 5; Involved in autophagic vesicle formation. Conjugation with Atg12, through a ubiquitin-like conjugating system involving Atg7 as an E1-like activating enzyme and Atg10 as an E2-like conjugating enzyme, is essential for its function. The Atg12-Atg5 conjugate acts as an E3- like enzyme which is required for lipidation of Atg8 and its association to the vesicle membranes (By similarity). | Protein ref(2)P; Required for selective autophagy activation by ubiquitinated proteins. Implicated in sigma rhabdovirus multiplication and necessary for male fertility. Involved in activating transcription of Drs. | 0.957 |
CG17140 | Atg5 | FBpp0100169 | FBpp0071023 | MIP04751p; Voltage-gated anion channel activity; channel activity. It is involved in the biological process described with: anion transmembrane transport. | Autophagy protein 5; Involved in autophagic vesicle formation. Conjugation with Atg12, through a ubiquitin-like conjugating system involving Atg7 as an E1-like activating enzyme and Atg10 as an E2-like conjugating enzyme, is essential for its function. The Atg12-Atg5 conjugate acts as an E3- like enzyme which is required for lipidation of Atg8 and its association to the vesicle membranes (By similarity). | 0.608 |
CG17140 | COX5BL | FBpp0100169 | FBpp0078919 | MIP04751p; Voltage-gated anion channel activity; channel activity. It is involved in the biological process described with: anion transmembrane transport. | Cytochrome-c oxidase activity. It is involved in the biological process described with: mitochondrial electron transport, cytochrome c to oxygen; mitochondrial ATP synthesis coupled proton transport. | 0.698 |
CG17140 | Marf | FBpp0100169 | FBpp0310030 | MIP04751p; Voltage-gated anion channel activity; channel activity. It is involved in the biological process described with: anion transmembrane transport. | Transmembrane GTPase Marf; Mitochondrial assembly regulatory factor (Marf) encodes a dynamin-family GTPase that mediates outer mitochondrial membrane tethering and fusion. Marf loss causes mitochondrial fragmentation and endoplasmic reticular stress that evoke skeletal muscle, retinal and heart tube dysfunction; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. Mitofusin subfamily. | 0.613 |
CG17140 | Pink1 | FBpp0100169 | FBpp0099833 | MIP04751p; Voltage-gated anion channel activity; channel activity. It is involved in the biological process described with: anion transmembrane transport. | PTEN-induced putative kinase 1 (Pink1) is the ortholog of human PINK1, a gene mutated in autosomal recessive Parkinson's disease. Pink1 encodes a mitochondrially targeted Ser-Thr kinase. It has been linked to a number of cellular functions including altering mitochondrial dynamics, the autophagic degradation of dysfunctional mitochondria, and the proper function of Complex I of the electron transport chain. | 0.631 |
CG17140 | Porin2 | FBpp0100169 | FBpp0079773 | MIP04751p; Voltage-gated anion channel activity; channel activity. It is involved in the biological process described with: anion transmembrane transport. | Voltage-dependent anion-selective channel protein 2; Porin2 (Porin2) encodes a protein with voltage-independent cation-selective pore activity that is involved in ion transport. | 0.666 |
CG17140 | Tom20 | FBpp0100169 | FBpp0304965 | MIP04751p; Voltage-gated anion channel activity; channel activity. It is involved in the biological process described with: anion transmembrane transport. | Translocase of outer membrane 20, isoform A; Mitochondrion targeting sequence binding; P-P-bond-hydrolysis-driven protein transmembrane transporter activity. It is involved in the biological process described with: protein targeting to mitochondrion; tRNA import into mitochondrion; mitochondrial outer membrane translocase complex assembly; protein import into mitochondrial matrix. | 0.620 |
CG17140 | Tom70 | FBpp0100169 | FBpp0079895 | MIP04751p; Voltage-gated anion channel activity; channel activity. It is involved in the biological process described with: anion transmembrane transport. | Translocase of outer membrane 70 (Tom70) encodes a mitochondrial protein that may act as a receptor of the TOM complex based on orthology. TOM complex is involved in protein import into mitochondria. The product of Tom70 modulates cell death induced by the expression of the mouse Bax protein. | 0.626 |
CG17140 | fzo | FBpp0100169 | FBpp0083791 | MIP04751p; Voltage-gated anion channel activity; channel activity. It is involved in the biological process described with: anion transmembrane transport. | Transmembrane GTPase fzo; Essential transmembrane GTPase, which mediates mitochondrial fusion during spermatogenesis. In early spermatocytes, fusion of mitochondria give rise to two organelles named Nebenkern and constitutes an important step in mitochondria morphology, which is balanced between fusion and fission. Essential for fertility. | 0.635 |
CG17140 | park | FBpp0100169 | FBpp0077974 | MIP04751p; Voltage-gated anion channel activity; channel activity. It is involved in the biological process described with: anion transmembrane transport. | Parkin (park) encodes an E3 ubiquitin ligase with a key role in protein ubiquitination. It is involved in mitochondrion organization, oxidative stress and locomotion; Belongs to the RBR family. Parkin subfamily. | 0.681 |
CG17140 | ref(2)P | FBpp0100169 | FBpp0099683 | MIP04751p; Voltage-gated anion channel activity; channel activity. It is involved in the biological process described with: anion transmembrane transport. | Protein ref(2)P; Required for selective autophagy activation by ubiquitinated proteins. Implicated in sigma rhabdovirus multiplication and necessary for male fertility. Involved in activating transcription of Drs. | 0.606 |
COX5BL | CG17140 | FBpp0078919 | FBpp0100169 | Cytochrome-c oxidase activity. It is involved in the biological process described with: mitochondrial electron transport, cytochrome c to oxygen; mitochondrial ATP synthesis coupled proton transport. | MIP04751p; Voltage-gated anion channel activity; channel activity. It is involved in the biological process described with: anion transmembrane transport. | 0.698 |
COX5BL | Porin2 | FBpp0078919 | FBpp0079773 | Cytochrome-c oxidase activity. It is involved in the biological process described with: mitochondrial electron transport, cytochrome c to oxygen; mitochondrial ATP synthesis coupled proton transport. | Voltage-dependent anion-selective channel protein 2; Porin2 (Porin2) encodes a protein with voltage-independent cation-selective pore activity that is involved in ion transport. | 0.448 |