STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CG40485RH03309p; Estradiol 17-beta-dehydrogenase activity; 17-beta-ketosteroid reductase activity; 3-keto sterol reductase activity; 17-beta-hydroxysteroid dehydrogenase (NADP+) activity; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (247 aa)    
Predicted Functional Partners:
Aldh
Aldehyde dehydrogenase (Aldh) encodes an NAD[+] dependent mitochondrial aldehyde dehydrogenase. Its functions include detoxifying endogenous aldehydes generated by lipid peroxidation, and detoxifying acetaldehyde derived from dietary ethanol.
  
 0.949
CG15739
RE04130p; Phosphatase activity. It is involved in the biological process described with: dephosphorylation; Belongs to the HAD-like hydrolase superfamily.
     
 0.942
CG2680
RE47284p; Phosphatase activity; phosphoprotein phosphatase activity. It is involved in the biological process described with: dephosphorylation; protein dephosphorylation; Belongs to the HAD-like hydrolase superfamily.
     
 0.941
CG10352
Phosphatase activity; phosphoprotein phosphatase activity. It is involved in the biological process described with: protein dephosphorylation; dephosphorylation; Belongs to the HAD-like hydrolase superfamily.
   
 
 0.941
CG31075
Uncharacterized protein, isoform B; Aldehyde dehydrogenase (NAD+) activity. It is involved in the biological process described with: oxidation-reduction process; pyruvate metabolic process.
  
 0.909
Hmgs
3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.
  
  
 0.692
Jheh1
Juvenile hormone epoxide hydrolase 1 (Jheh1) expression changes are associated with increased tolerance to oxidative stress; Belongs to the peptidase S33 family.
  
 
 0.686
CG42346
Uncharacterized protein, isoform C.
    
 
 0.679
Jheh3
Epoxide hydrolase; Catalyzes juvenile hormone hydrolysis. Belongs to the peptidase S33 family.
  
 
 0.674
CG10527
Uncharacterized protein.
    
 
 0.667
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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