STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ShalPotassium voltage-gated channel protein Shal; Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. May play a role in the nervous system and in the regulation of beating frequency in pacemaker cells. (571 aa)    
Predicted Functional Partners:
CG5890
Uncharacterized protein, isoform E; Calcium ion binding. It is involved in the biological process described with: wing disc dorsal/ventral pattern formation.
   
 0.974
CG44422
Uncharacterized protein, isoform A; Calcium ion binding.
   
 0.943
eag
Potassium voltage-gated channel protein eag; Structural component of a potassium channel. Mediates the potassium permeability of membranes; potassium current is regulated by CaMKII and CASK. Has a role in growth of the perineurial glial layer of the larval peripheral nerve.
   
 0.938
RpL31
60S ribosomal protein L31; Structural constituent of ribosome. It is involved in the biological process described with: cytoplasmic translation; Belongs to the eukaryotic ribosomal protein eL31 family.
   
 
 0.887
RpL37A
60S ribosomal protein L37a; Structural constituent of ribosome. It is involved in the biological process described with: cytoplasmic translation; translation; Belongs to the eukaryotic ribosomal protein eL43 family.
   
 
 0.887
RpS24
Ribosomal protein S24 (RpS24) encodes an essential component of the small ribosomal subunit that functions in protein synthesis. It is classified as a 'Minute' gene as heterozygous mutants exhibit a slower developmental rate and small adult bristles; Belongs to the eukaryotic ribosomal protein eS24 family.
   
 
 0.886
RpL21
Ribosomal protein L21, isoform A; Structural constituent of ribosome. It is involved in the biological process described with: translation; cytoplasmic translation.
   
 
 0.882
RpL32
60S ribosomal protein L32; Structural constituent of ribosome. It is involved in the biological process described with: translation; cytoplasmic translation.
  
 
 0.880
RpL23A
Ribosomal protein L23A (RpL23A) encodes an essential ribosomal RNA binding protein of the large ribosomal subunit involved in protein synthesis; Belongs to the universal ribosomal protein uL23 family.
   
 
 0.880
RpL38
Ribosomal protein L38 (RpL38) encodes a component of the large subunit of cytoplasmic ribosomes, which translate mRNAs encoded by the nuclear genome. RpL38 is haploinsufficient - heterozygous mutants display the 'Minute' phenotype, characterized by a slower developmental rate and small adult bristles.
   
 
 0.879
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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