node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Burs | CCAP | FBpp0083529 | FBpp0083726 | Bursicon (Burs) encodes a cystine knot protein that dimerizes with the product of Pburs to form the bursicon neurohormone. Bursicon neurohormone is released after adult emergence and acts on the receptor encoded by rk for tanning and hardening of the cuticle and expansion of the wings. | Crustacean cardioactive peptide (CCAP) encodes a conserved 9 amino acid neuropeptide. It is produced by 1-2 neurons in each segment of the ventral nervous system and is released during the shedding of the old exoskeleton (ecdysis). It also has cardioactive functions. | 0.935 |
Burs | Dh44 | FBpp0083529 | FBpp0310724 | Bursicon (Burs) encodes a cystine knot protein that dimerizes with the product of Pburs to form the bursicon neurohormone. Bursicon neurohormone is released after adult emergence and acts on the receptor encoded by rk for tanning and hardening of the cuticle and expansion of the wings. | Diuretic hormone 44, isoform A; Hormone activity; G protein-coupled receptor binding; diuretic hormone activity; neuropeptide hormone activity. It is involved in the biological process described with: locomotor rhythm; G protein-coupled receptor signaling pathway; neuropeptide signaling pathway; body fluid secretion; hormone-mediated signaling pathway. | 0.711 |
Burs | Gpa2 | FBpp0083529 | FBpp0423268 | Bursicon (Burs) encodes a cystine knot protein that dimerizes with the product of Pburs to form the bursicon neurohormone. Bursicon neurohormone is released after adult emergence and acts on the receptor encoded by rk for tanning and hardening of the cuticle and expansion of the wings. | Glycoprotein hormone alpha 2 (Gpa2) encodes a protein that, when linked to the product of Gpb5, can activate the G protein-coupled receptor encoded by Lgr1. | 0.797 |
Burs | Gpb5 | FBpp0083529 | FBpp0112499 | Bursicon (Burs) encodes a cystine knot protein that dimerizes with the product of Pburs to form the bursicon neurohormone. Bursicon neurohormone is released after adult emergence and acts on the receptor encoded by rk for tanning and hardening of the cuticle and expansion of the wings. | Glycoprotein hormone beta 5 (Gpb5) encodes a ligand of the G protein-coupled receptor encoded by Lgr1. It is involved in hormone-mediated signaling. | 0.857 |
Burs | Lgr1 | FBpp0083529 | FBpp0082934 | Bursicon (Burs) encodes a cystine knot protein that dimerizes with the product of Pburs to form the bursicon neurohormone. Bursicon neurohormone is released after adult emergence and acts on the receptor encoded by rk for tanning and hardening of the cuticle and expansion of the wings. | Leucine-rich repeat-containing G protein-coupled receptor 1 (Lgr1) encodes a Leucine-rich repeat-containing G protein-coupled receptor (LGR type A) that shows highest similarity with vertebrate glycoprotein hormone (TSH and Thyrostimulin, FSH, LH ) receptors. | 0.689 |
Burs | NPF | FBpp0083529 | FBpp0304075 | Bursicon (Burs) encodes a cystine knot protein that dimerizes with the product of Pburs to form the bursicon neurohormone. Bursicon neurohormone is released after adult emergence and acts on the receptor encoded by rk for tanning and hardening of the cuticle and expansion of the wings. | Neuropeptide F; Integral part of the sensory system that mediates food signaling, providing the neural basis for the regulation of food response; coordinates larval foraging and social behavior changes during development. Required in dopaminergic (DA) neurons that innervate the mushroom body for satiety to suppress appetitive memory performance; a key factor in the internal state of hunger in the brain. NPF neurons coordinately modulate diverse sensory and motor neurons important for feeding, flight, and locomotion. NPF/NPFR pathway exerts its suppressive effect on larval aversion to d [...] | 0.750 |
Burs | Pdf | FBpp0083529 | FBpp0084396 | Bursicon (Burs) encodes a cystine knot protein that dimerizes with the product of Pburs to form the bursicon neurohormone. Bursicon neurohormone is released after adult emergence and acts on the receptor encoded by rk for tanning and hardening of the cuticle and expansion of the wings. | PDF precursor-related peptide; Pigment-dispersing factor (Pdf) encodes a secreted biologically active neuropeptide that acts via a specific G-protein-coupled receptor to trigger intracellular signaling. It has a prominent role in the physiology of circadian rhythms, as well as contributing to other processes such as control of flight and digestion. | 0.680 |
Burs | Trissin | FBpp0083529 | FBpp0289411 | Bursicon (Burs) encodes a cystine knot protein that dimerizes with the product of Pburs to form the bursicon neurohormone. Bursicon neurohormone is released after adult emergence and acts on the receptor encoded by rk for tanning and hardening of the cuticle and expansion of the wings. | Trissin; Activates the G-protein coupled receptor TrissinR in vitro, leading to increased intracellular calcium ion levels. | 0.662 |
Burs | rk | FBpp0083529 | FBpp0080183 | Bursicon (Burs) encodes a cystine knot protein that dimerizes with the product of Pburs to form the bursicon neurohormone. Bursicon neurohormone is released after adult emergence and acts on the receptor encoded by rk for tanning and hardening of the cuticle and expansion of the wings. | Rickets (rk) encodes a G-protein coupled receptor that signals intracellularly using the second messenger cAMP. It binds the heterodimeric hormone bursicon and is developmentally important for molting-related behaviors. It is also required after adult emergence for cuticle hardening and melanization. | 0.977 |
Burs | sNPF | FBpp0083529 | FBpp0080859 | Bursicon (Burs) encodes a cystine knot protein that dimerizes with the product of Pburs to form the bursicon neurohormone. Bursicon neurohormone is released after adult emergence and acts on the receptor encoded by rk for tanning and hardening of the cuticle and expansion of the wings. | Short neuropeptide F precursor (sNPF) encodes a protein that binds to the product of sNPF-R and activates ERK-Dilps signaling or the PKA-CREB pathway. Its roles include the regulation of cell and organism growth, carbohydrate metabolism, lifespan, feeding behavior, locomotion, circadian rhythm, and sleep. | 0.723 |
CCAP | Burs | FBpp0083726 | FBpp0083529 | Crustacean cardioactive peptide (CCAP) encodes a conserved 9 amino acid neuropeptide. It is produced by 1-2 neurons in each segment of the ventral nervous system and is released during the shedding of the old exoskeleton (ecdysis). It also has cardioactive functions. | Bursicon (Burs) encodes a cystine knot protein that dimerizes with the product of Pburs to form the bursicon neurohormone. Bursicon neurohormone is released after adult emergence and acts on the receptor encoded by rk for tanning and hardening of the cuticle and expansion of the wings. | 0.935 |
CCAP | Dh44 | FBpp0083726 | FBpp0310724 | Crustacean cardioactive peptide (CCAP) encodes a conserved 9 amino acid neuropeptide. It is produced by 1-2 neurons in each segment of the ventral nervous system and is released during the shedding of the old exoskeleton (ecdysis). It also has cardioactive functions. | Diuretic hormone 44, isoform A; Hormone activity; G protein-coupled receptor binding; diuretic hormone activity; neuropeptide hormone activity. It is involved in the biological process described with: locomotor rhythm; G protein-coupled receptor signaling pathway; neuropeptide signaling pathway; body fluid secretion; hormone-mediated signaling pathway. | 0.686 |
CCAP | Gpa2 | FBpp0083726 | FBpp0423268 | Crustacean cardioactive peptide (CCAP) encodes a conserved 9 amino acid neuropeptide. It is produced by 1-2 neurons in each segment of the ventral nervous system and is released during the shedding of the old exoskeleton (ecdysis). It also has cardioactive functions. | Glycoprotein hormone alpha 2 (Gpa2) encodes a protein that, when linked to the product of Gpb5, can activate the G protein-coupled receptor encoded by Lgr1. | 0.673 |
CCAP | Gpb5 | FBpp0083726 | FBpp0112499 | Crustacean cardioactive peptide (CCAP) encodes a conserved 9 amino acid neuropeptide. It is produced by 1-2 neurons in each segment of the ventral nervous system and is released during the shedding of the old exoskeleton (ecdysis). It also has cardioactive functions. | Glycoprotein hormone beta 5 (Gpb5) encodes a ligand of the G protein-coupled receptor encoded by Lgr1. It is involved in hormone-mediated signaling. | 0.844 |
CCAP | Lgr1 | FBpp0083726 | FBpp0082934 | Crustacean cardioactive peptide (CCAP) encodes a conserved 9 amino acid neuropeptide. It is produced by 1-2 neurons in each segment of the ventral nervous system and is released during the shedding of the old exoskeleton (ecdysis). It also has cardioactive functions. | Leucine-rich repeat-containing G protein-coupled receptor 1 (Lgr1) encodes a Leucine-rich repeat-containing G protein-coupled receptor (LGR type A) that shows highest similarity with vertebrate glycoprotein hormone (TSH and Thyrostimulin, FSH, LH ) receptors. | 0.498 |
CCAP | NPF | FBpp0083726 | FBpp0304075 | Crustacean cardioactive peptide (CCAP) encodes a conserved 9 amino acid neuropeptide. It is produced by 1-2 neurons in each segment of the ventral nervous system and is released during the shedding of the old exoskeleton (ecdysis). It also has cardioactive functions. | Neuropeptide F; Integral part of the sensory system that mediates food signaling, providing the neural basis for the regulation of food response; coordinates larval foraging and social behavior changes during development. Required in dopaminergic (DA) neurons that innervate the mushroom body for satiety to suppress appetitive memory performance; a key factor in the internal state of hunger in the brain. NPF neurons coordinately modulate diverse sensory and motor neurons important for feeding, flight, and locomotion. NPF/NPFR pathway exerts its suppressive effect on larval aversion to d [...] | 0.839 |
CCAP | Pdf | FBpp0083726 | FBpp0084396 | Crustacean cardioactive peptide (CCAP) encodes a conserved 9 amino acid neuropeptide. It is produced by 1-2 neurons in each segment of the ventral nervous system and is released during the shedding of the old exoskeleton (ecdysis). It also has cardioactive functions. | PDF precursor-related peptide; Pigment-dispersing factor (Pdf) encodes a secreted biologically active neuropeptide that acts via a specific G-protein-coupled receptor to trigger intracellular signaling. It has a prominent role in the physiology of circadian rhythms, as well as contributing to other processes such as control of flight and digestion. | 0.701 |
CCAP | Trissin | FBpp0083726 | FBpp0289411 | Crustacean cardioactive peptide (CCAP) encodes a conserved 9 amino acid neuropeptide. It is produced by 1-2 neurons in each segment of the ventral nervous system and is released during the shedding of the old exoskeleton (ecdysis). It also has cardioactive functions. | Trissin; Activates the G-protein coupled receptor TrissinR in vitro, leading to increased intracellular calcium ion levels. | 0.797 |
CCAP | rk | FBpp0083726 | FBpp0080183 | Crustacean cardioactive peptide (CCAP) encodes a conserved 9 amino acid neuropeptide. It is produced by 1-2 neurons in each segment of the ventral nervous system and is released during the shedding of the old exoskeleton (ecdysis). It also has cardioactive functions. | Rickets (rk) encodes a G-protein coupled receptor that signals intracellularly using the second messenger cAMP. It binds the heterodimeric hormone bursicon and is developmentally important for molting-related behaviors. It is also required after adult emergence for cuticle hardening and melanization. | 0.602 |
CCAP | sNPF | FBpp0083726 | FBpp0080859 | Crustacean cardioactive peptide (CCAP) encodes a conserved 9 amino acid neuropeptide. It is produced by 1-2 neurons in each segment of the ventral nervous system and is released during the shedding of the old exoskeleton (ecdysis). It also has cardioactive functions. | Short neuropeptide F precursor (sNPF) encodes a protein that binds to the product of sNPF-R and activates ERK-Dilps signaling or the PKA-CREB pathway. Its roles include the regulation of cell and organism growth, carbohydrate metabolism, lifespan, feeding behavior, locomotion, circadian rhythm, and sleep. | 0.847 |