STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
St1Sulfotransferase 1 (St1) encodes one out of 4 sulfotransferases that catalyze the sulfonation of many proteins, lipids and glycosaminoglycans. (338 aa)    
Predicted Functional Partners:
TH1
Negative elongation factor D; TH1 (TH1) encodes one of four subunits that constitutes the NELF complex. The NELF complex along with DSIF causes RNA polymerase II to pause 20 to 50 nucleotides downstream from the transcription start site of most and possibly all actively transcribed genes in a process commonly called promoter proximal pausing.
      
 0.835
GlcAT-I
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase I; Involved in the biosynthesis of L2/HNK-1 carbohydrate epitope on both glycolipids and glycoproteins. Shows strict specificity for Gal-beta-1,3-Gal-beta-1,4-Xyl, exhibiting negligible incorporation into other galactoside substrates; Belongs to the glycosyltransferase 43 family.
      
 0.628
St3
Sulfotransferase 3 (St3) encodes an enzyme involved in sulfation, xenobiotic metabolism and the defense response to bacteria.
  
 
0.543
St4
Sulfotransferase 4 (St4) encodes one out of 4 sulfotransferases that catalyze the sulfonation of many proteins, lipids and glycosaminoglycans.
  
 
0.537
St2
Sulfotransferase 2 (St2) encodes one out of 4 sulfotransferases that catalyze the sulfonation of many proteins, lipids and glycosaminoglycans.
  
  
0.528
Hk
Hyperkinetic, isoform M; Hyperkinetic (Hk) encodes a beta-subunit of Sh K[+] channels and modulates its channel function. It is important in regulating action potentials in neurons and muscles, and transmitter release.
      
 0.513
CG14024
Sulfotransferase activity. It is involved in the biological process described with: carbohydrate biosynthetic process.
      
 0.509
Sulf1
Extracellular sulfatase SULF-1 homolog; Sulfated (Sulf1) encodes a heparan sulfate modifying enzyme, which extracellularly removes specific 6-O-sulfate groups from heparan sulfate in a post-synthetic manner. It regulates Wg signaling by reducing extracellular wg protein levels. It also regulates Hh signaling by acting as a positive regulator in cells producing the product of hh and a negative regulator in cells receiving the product of hh.
      
 0.492
beta4GalT7
Beta-4-galactosyltransferase 7 (beta4GalT7) encodes an enzyme that transfers a Gal to the Xyl-O-Ser in the tetrasaccharide structure of the protein-linkage region of glycosaminoglycans (GAGs). It is involved in Hh and Dpp signaling pathways mediated by GAGs in development.
      
 0.491
sll
Slalom (sll) encodes the first transporter of 3'-phosphoadenosine 5'-phosphosulfate (PAPS), that transfers PAPS from cytosol into the lumen of Golgi. It contributes to the sulfation of glycans and proteins, the regulation of several signaling pathways (Hh, Wingless) mediated by glycosaminoglycans during patterning and morphogenesis, and the determination of the embryonic dorsal/ventral axis; Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.
      
 0.490
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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