node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CG13526 | CG13898 | FBpp0071789 | FBpp0072496 | Uncharacterized protein; Calcium ion binding. It is involved in the biological process described with: calcium-mediated signaling. | GEO12020p1; Calcium ion binding. It is involved in the biological process described with: calcium-mediated signaling. | 0.583 |
CG13526 | CG30378 | FBpp0071789 | FBpp0087930 | Uncharacterized protein; Calcium ion binding. It is involved in the biological process described with: calcium-mediated signaling. | Uncharacterized protein; Calcium ion binding. | 0.519 |
CG13526 | Cam | FBpp0071789 | FBpp0293502 | Uncharacterized protein; Calcium ion binding. It is involved in the biological process described with: calcium-mediated signaling. | Calmodulin; Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+) (By similarity). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases (By similarity). In photoreceptor cells, light-induced Ca(2+) influx activates calmodulin, which in turn is likely to promote Crag activity in trafficking of newly synthesized ninaE (Rh1) from the trans-Golgi network to rhabdomere membranes. Together with Akap200, regulates PKA activity and ethanol-induced sensitivity and tolerance. | 0.843 |
CG13526 | Itpr | FBpp0071789 | FBpp0078336 | Uncharacterized protein; Calcium ion binding. It is involved in the biological process described with: calcium-mediated signaling. | Inositol 1,4,5,-trisphosphate receptor (Itpr) encodes an intracellular ligand gated calcium channel. It functions downstream of G-protein coupled receptors that activate Gq/PLCbeta signaling and generate inositol tris-phosphate. Itpr depletion affects ecdysone release, response to nutritional stress, lipid metabolism and flight; Belongs to the InsP3 receptor family. | 0.919 |
CG13526 | NFAT | FBpp0071789 | FBpp0111893 | Uncharacterized protein; Calcium ion binding. It is involved in the biological process described with: calcium-mediated signaling. | NFAT nuclear factor, isoform B; DNA-binding transcription factor activity; chromatin binding; transcription factor binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding. It is involved in the biological process described with: positive regulation of transcription by RNA polymerase II; negative regulation of synaptic vesicle exocytosis; response to salt stress. | 0.851 |
CG13526 | Orai | FBpp0071789 | FBpp0307680 | Uncharacterized protein; Calcium ion binding. It is involved in the biological process described with: calcium-mediated signaling. | Calcium release-activated calcium channel protein 1; Ca(2+) release-activated Ca(2+) (CRAC) channel subunit which mediates Ca(2+) influx following depletion of intracellular Ca(2+) stores. Regulates transcription factor NFAT nuclear import. | 0.823 |
CG13526 | SERCA | FBpp0071789 | FBpp0072125 | Uncharacterized protein; Calcium ion binding. It is involved in the biological process described with: calcium-mediated signaling. | Calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type; Sarco/endoplasmic reticulum Ca(2+)-ATPase (SERCA) encodes an endoplasmic reticulum (ER) calcium pump with roles in ER calcium homeostasis and lipid storage. | 0.836 |
CG13526 | Stim | FBpp0071789 | FBpp0073955 | Uncharacterized protein; Calcium ion binding. It is involved in the biological process described with: calcium-mediated signaling. | Stromal interaction molecule (Stim) encodes an endomasplic reticulum-membrane protein that is an essential component of the store-operated calcium entry mechanism, which in neurons regulates flight. | 0.735 |
CG13526 | Tm1 | FBpp0071789 | FBpp0088904 | Uncharacterized protein; Calcium ion binding. It is involved in the biological process described with: calcium-mediated signaling. | Tropomyosin-1, isoforms 9A/A/B; Tropomyosin, in association with the troponin complex, plays a central role in the calcium dependent regulation of muscle contraction; Belongs to the tropomyosin family. | 0.558 |
CG13526 | Tm2 | FBpp0071789 | FBpp0089270 | Uncharacterized protein; Calcium ion binding. It is involved in the biological process described with: calcium-mediated signaling. | Tropomyosin-2; Tropomyosin, in association with the troponin complex, plays a central role in the calcium dependent regulation of muscle contraction. May also regulate motor systems required to maintain nuclear integrity and apico-basal polarity during embryogenesis. | 0.480 |
CG13898 | CG13526 | FBpp0072496 | FBpp0071789 | GEO12020p1; Calcium ion binding. It is involved in the biological process described with: calcium-mediated signaling. | Uncharacterized protein; Calcium ion binding. It is involved in the biological process described with: calcium-mediated signaling. | 0.583 |
CG13898 | CG30378 | FBpp0072496 | FBpp0087930 | GEO12020p1; Calcium ion binding. It is involved in the biological process described with: calcium-mediated signaling. | Uncharacterized protein; Calcium ion binding. | 0.538 |
CG13898 | Cam | FBpp0072496 | FBpp0293502 | GEO12020p1; Calcium ion binding. It is involved in the biological process described with: calcium-mediated signaling. | Calmodulin; Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+) (By similarity). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases (By similarity). In photoreceptor cells, light-induced Ca(2+) influx activates calmodulin, which in turn is likely to promote Crag activity in trafficking of newly synthesized ninaE (Rh1) from the trans-Golgi network to rhabdomere membranes. Together with Akap200, regulates PKA activity and ethanol-induced sensitivity and tolerance. | 0.840 |
CG13898 | Itpr | FBpp0072496 | FBpp0078336 | GEO12020p1; Calcium ion binding. It is involved in the biological process described with: calcium-mediated signaling. | Inositol 1,4,5,-trisphosphate receptor (Itpr) encodes an intracellular ligand gated calcium channel. It functions downstream of G-protein coupled receptors that activate Gq/PLCbeta signaling and generate inositol tris-phosphate. Itpr depletion affects ecdysone release, response to nutritional stress, lipid metabolism and flight; Belongs to the InsP3 receptor family. | 0.919 |
CG13898 | NFAT | FBpp0072496 | FBpp0111893 | GEO12020p1; Calcium ion binding. It is involved in the biological process described with: calcium-mediated signaling. | NFAT nuclear factor, isoform B; DNA-binding transcription factor activity; chromatin binding; transcription factor binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding. It is involved in the biological process described with: positive regulation of transcription by RNA polymerase II; negative regulation of synaptic vesicle exocytosis; response to salt stress. | 0.850 |
CG13898 | Orai | FBpp0072496 | FBpp0307680 | GEO12020p1; Calcium ion binding. It is involved in the biological process described with: calcium-mediated signaling. | Calcium release-activated calcium channel protein 1; Ca(2+) release-activated Ca(2+) (CRAC) channel subunit which mediates Ca(2+) influx following depletion of intracellular Ca(2+) stores. Regulates transcription factor NFAT nuclear import. | 0.823 |
CG13898 | SERCA | FBpp0072496 | FBpp0072125 | GEO12020p1; Calcium ion binding. It is involved in the biological process described with: calcium-mediated signaling. | Calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type; Sarco/endoplasmic reticulum Ca(2+)-ATPase (SERCA) encodes an endoplasmic reticulum (ER) calcium pump with roles in ER calcium homeostasis and lipid storage. | 0.836 |
CG13898 | Stim | FBpp0072496 | FBpp0073955 | GEO12020p1; Calcium ion binding. It is involved in the biological process described with: calcium-mediated signaling. | Stromal interaction molecule (Stim) encodes an endomasplic reticulum-membrane protein that is an essential component of the store-operated calcium entry mechanism, which in neurons regulates flight. | 0.728 |
CG13898 | Tm1 | FBpp0072496 | FBpp0088904 | GEO12020p1; Calcium ion binding. It is involved in the biological process described with: calcium-mediated signaling. | Tropomyosin-1, isoforms 9A/A/B; Tropomyosin, in association with the troponin complex, plays a central role in the calcium dependent regulation of muscle contraction; Belongs to the tropomyosin family. | 0.558 |
CG13898 | Tm2 | FBpp0072496 | FBpp0089270 | GEO12020p1; Calcium ion binding. It is involved in the biological process described with: calcium-mediated signaling. | Tropomyosin-2; Tropomyosin, in association with the troponin complex, plays a central role in the calcium dependent regulation of muscle contraction. May also regulate motor systems required to maintain nuclear integrity and apico-basal polarity during embryogenesis. | 0.480 |