STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
THADAThyroid adenoma-associated protein homolog; Plays a key role in energy homeostasis by regulating the balance between energy storage and heat production. Functions by negatively regulating Ca(2+) signaling pathways that are involved in heat production and maintaining correct lipid storage in the fat body. Regulates Ca(2+) signaling pathways by reducing the activity of the calcium-transporting ATPase SERCA possibly by promoting uncoupling of SERCA ATP hydrolysis from calcium pumping. May also function in the nervous system to control feeding behavior. (1746 aa)    
Predicted Functional Partners:
Trm7-34
Putative tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase 2; Methylates the 2'-O-ribose of nucleotides at positions 32 and 34 of the tRNA anticodon loop of substrate tRNAs.
   
 
 0.961
Trm7-32
Putative tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase 1; Methylates the 2'-O-ribose of nucleotides at positions 32 and 34 of the tRNA anticodon loop of substrate tRNAs.
   
 
 0.939
CG33172
MIP10235p; RNA binding. It is involved in the biological process described with: negative regulation of cell population proliferation.
   
 
 0.871
Npc2g
Niemann-Pick type C-2g, isoform A; Sterol binding. It is involved in the biological process described with: intracellular cholesterol transport; sterol transport; mesoderm development.
      
 0.603
RpI1
DNA-directed RNA polymerase I subunit RPA1; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic core component of RNA polymerase I which synthesizes ribosomal RNA precursors. Forms the polymerase active center together with the second largest subunit. A single stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol I. A bridging helix emanates from RPA1 and crosses the cleft near the catalytic site and is thought to promote translocation o [...]
   
    0.554
CG8939
Putative rRNA methyltransferase; Probable methyltransferase involved in the maturation of rRNA and in the biogenesis of ribosomal subunits.
   
 
 0.545
CG11447
rRNA methyltransferase 2, mitochondrial; S-adenosyl-L-methionine-dependent 2'-O-ribose methyltransferase that catalyzes the formation of 2'-O-methyluridine at position 1579 (Um1579) in the mitochondrial large subunit ribosomal RNA (mtLSU rRNA), a universally conserved modification in the peptidyl transferase domain of the mtLSU rRNA.
   
 
 0.540
wuho
tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit wuho; Required for the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. In the complex, it is required to stabilize and induce conformational changes of the catalytic subunit. Required during gametogenesis.
   
  
 0.515
CG1074
SD03208p; Methyltransferase activity; tRNA (guanine-N2-)-methyltransferase activity; nucleic acid binding. It is involved in the biological process described with: methylation.
   
  
 0.503
Nplp3
Neuropeptide-like 3; Neuropeptide hormone activity. It is involved in the biological process described with: neuropeptide signaling pathway.
      
 0.495
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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