STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
sonaSol narae (sona) encodes a member of the ADAMTS family of proteases secreted to the extracellular matrix. It is involved in Wg signaling by promoting the secretion of the product of wg, and is essential for development and growth. (1102 aa)    
Predicted Functional Partners:
wg
Protein wingless; Binds as a ligand to a family of frizzled seven-transmembrane receptors and acts through a cascade of genes on the nucleus. Segment polarity protein. May be a growth factor. Acts on neighboring cells to regulate at least one gene, the homeobox segmentation gene engrailed. Wg signal represses arm phosphorylation. Wg signaling operates by inactivating the sgg repression of engrailed autoactivation. Wg and Wnt2 have a role in the developing trachea and together are responsible for all dorsal trunk formation. Wg also acts in the developing epidermis. Acts as a morphogen, [...]
    
 
 0.643
Gart
Trifunctional purine biosynthetic protein adenosine-3; GART trifunctional enzyme (Gart) encodes a multifunctional enzyme that exhibits phosphoribosylamine-glycine ligase, phosphoribosylformylglycinamidine cyclo-ligase and phosphoribosylglycinamide formyltransferase activities; In the N-terminal section; belongs to the GARS family. In the C-terminal section; belongs to the GART family.
      
 0.605
loh
Lonely heart (loh) encodes a protein involved in larval heart development and regulation of the extracellular matrix assembly.
      
 0.506
ana3
Anastral spindle 3 (ana3) encodes a centriole and basal body localized protein that is required for the proper function of these organelles.
      
 0.502
CG7201
Uncharacterized protein, isoform A.
   
  
 0.495
pdm3
Pou domain motif 3 (pdm3) encodes a POU domain transcription factor that acts in odor receptor gene expression and axon targeting of olfactory neurons.
      
 0.495
CG42671
Uncharacterized protein, isoform K.
    
 
 0.492
CG13506
FI23916p1; Axon guidance receptor activity. It is involved in the biological process described with: synapse organization; homophilic cell adhesion via plasma membrane adhesion molecules.
      
 0.471
mxt
Eukaryotic translation initiation factor 4E-binding protein Mextli; Mextli (mxt) encodes a protein that promotes translation. It binds to the products of eIF4E1 and eIF3h. It contributes to maintenance of germline stem cells and it is also involved in early embryogenesis.
      
 0.469
CG17839
Uncharacterized protein, isoform B.
    
 
 0.464
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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