node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Arr2 | inaD | FBpp0076326 | FBpp0293662 | Phosrestin-1; Arrestin 2 (Arr2) encodes a protein involved in rhodopsin inactivation that contributes to photoreceptor maintenance and smell and sound perception. | Inactivation-no-after-potential D protein; Involved in the negative feedback regulation of the light- activated signaling cascade in photoreceptors through a calcium- mediated process. Interacts with tetrapeptide ligand located in C- terminal sequence of 3 key components of the visual cascade, tethering them and forming a macromolecular signaling phototransduction complex. | 0.961 |
Arr2 | inaE | FBpp0076326 | FBpp0288741 | Phosrestin-1; Arrestin 2 (Arr2) encodes a protein involved in rhodopsin inactivation that contributes to photoreceptor maintenance and smell and sound perception. | Inactivation no afterpotential E (inaE) encodes a diacylglycerol lipase involved in phototransduction and response to oxidative stress. | 0.541 |
Arr2 | ninaC | FBpp0076326 | FBpp0079064 | Phosrestin-1; Arrestin 2 (Arr2) encodes a protein involved in rhodopsin inactivation that contributes to photoreceptor maintenance and smell and sound perception. | Neither inactivation nor afterpotential protein C; Required for photoreceptor cell function. The ninaC proteins combines putative serine/threonine-protein kinase and myosin activities. Essential for the expression and stability of the rtp protein in the photoreceptors. The rtp/ninaC complex is required for stability of inad and inac and the normal termination of phototransduction in the retina. | 0.993 |
Arr2 | norpA | FBpp0076326 | FBpp0290690 | Phosrestin-1; Arrestin 2 (Arr2) encodes a protein involved in rhodopsin inactivation that contributes to photoreceptor maintenance and smell and sound perception. | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes (By similarity). Essential component of the phototransduction pathway. Essential downstream component of a hh-signaling pathway which regulates the Duox-dependent gut immune response to bacterial uracil; required for the activation of Cad99C and consequently Cad99C-dependent endosome formation, which is essential for the Duox-dependent product [...] | 0.941 |
Arr2 | rdgA | FBpp0076326 | FBpp0305778 | Phosrestin-1; Arrestin 2 (Arr2) encodes a protein involved in rhodopsin inactivation that contributes to photoreceptor maintenance and smell and sound perception. | Retinal degeneration A (rdgA) encodes a diacylglycerol kinase that mediates the conversion of diacylglycerol to phosphatidic acid. It contributes to phospholipase C based signalling reactions, controlling ion channel activity and protein transport. | 0.582 |
Arr2 | rdgB | FBpp0076326 | FBpp0304106 | Phosrestin-1; Arrestin 2 (Arr2) encodes a protein involved in rhodopsin inactivation that contributes to photoreceptor maintenance and smell and sound perception. | Retinal degeneration B (rdgB) encodes a member of the Class IIA Phosphatidylinositol transfer protein (PITP) family. It supports multiple biochemical functions involving lipid transfer during G-protein coupled phospholipase C activation. | 0.686 |
Arr2 | trpl | FBpp0076326 | FBpp0087557 | Phosrestin-1; Arrestin 2 (Arr2) encodes a protein involved in rhodopsin inactivation that contributes to photoreceptor maintenance and smell and sound perception. | Transient-receptor-potential-like protein; A light-sensitive calcium channel that is required for inositide-mediated Ca(2+) entry in the retina during phospholipase C (PLC)-mediated phototransduction. Required for vision in the dark and in dim light. Binds calmodulin. Trp and trpl act together in the light response, although it is unclear whether as heteromultimers or distinct units. Also forms a functional cation channel with Trpgamma. Activated by fatty acids, metabolic stress, inositols and GTP-binding proteins. | 0.966 |
CG11029 | CG6753 | FBpp0078767 | FBpp0290373 | MIP29934p; Phospholipase activity. It is involved in the biological process described with: phospholipid metabolic process. | Lipase; Hydrolase activity, acting on ester bonds. It is involved in the biological process described with: lipid metabolic process; Belongs to the AB hydrolase superfamily. Lipase family. | 0.918 |
CG11029 | inaE | FBpp0078767 | FBpp0288741 | MIP29934p; Phospholipase activity. It is involved in the biological process described with: phospholipid metabolic process. | Inactivation no afterpotential E (inaE) encodes a diacylglycerol lipase involved in phototransduction and response to oxidative stress. | 0.669 |
CG6753 | CG11029 | FBpp0290373 | FBpp0078767 | Lipase; Hydrolase activity, acting on ester bonds. It is involved in the biological process described with: lipid metabolic process; Belongs to the AB hydrolase superfamily. Lipase family. | MIP29934p; Phospholipase activity. It is involved in the biological process described with: phospholipid metabolic process. | 0.918 |
CG6753 | inaE | FBpp0290373 | FBpp0288741 | Lipase; Hydrolase activity, acting on ester bonds. It is involved in the biological process described with: lipid metabolic process; Belongs to the AB hydrolase superfamily. Lipase family. | Inactivation no afterpotential E (inaE) encodes a diacylglycerol lipase involved in phototransduction and response to oxidative stress. | 0.669 |
inaD | Arr2 | FBpp0293662 | FBpp0076326 | Inactivation-no-after-potential D protein; Involved in the negative feedback regulation of the light- activated signaling cascade in photoreceptors through a calcium- mediated process. Interacts with tetrapeptide ligand located in C- terminal sequence of 3 key components of the visual cascade, tethering them and forming a macromolecular signaling phototransduction complex. | Phosrestin-1; Arrestin 2 (Arr2) encodes a protein involved in rhodopsin inactivation that contributes to photoreceptor maintenance and smell and sound perception. | 0.961 |
inaD | inaE | FBpp0293662 | FBpp0288741 | Inactivation-no-after-potential D protein; Involved in the negative feedback regulation of the light- activated signaling cascade in photoreceptors through a calcium- mediated process. Interacts with tetrapeptide ligand located in C- terminal sequence of 3 key components of the visual cascade, tethering them and forming a macromolecular signaling phototransduction complex. | Inactivation no afterpotential E (inaE) encodes a diacylglycerol lipase involved in phototransduction and response to oxidative stress. | 0.602 |
inaD | ninaC | FBpp0293662 | FBpp0079064 | Inactivation-no-after-potential D protein; Involved in the negative feedback regulation of the light- activated signaling cascade in photoreceptors through a calcium- mediated process. Interacts with tetrapeptide ligand located in C- terminal sequence of 3 key components of the visual cascade, tethering them and forming a macromolecular signaling phototransduction complex. | Neither inactivation nor afterpotential protein C; Required for photoreceptor cell function. The ninaC proteins combines putative serine/threonine-protein kinase and myosin activities. Essential for the expression and stability of the rtp protein in the photoreceptors. The rtp/ninaC complex is required for stability of inad and inac and the normal termination of phototransduction in the retina. | 0.998 |
inaD | norpA | FBpp0293662 | FBpp0290690 | Inactivation-no-after-potential D protein; Involved in the negative feedback regulation of the light- activated signaling cascade in photoreceptors through a calcium- mediated process. Interacts with tetrapeptide ligand located in C- terminal sequence of 3 key components of the visual cascade, tethering them and forming a macromolecular signaling phototransduction complex. | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes (By similarity). Essential component of the phototransduction pathway. Essential downstream component of a hh-signaling pathway which regulates the Duox-dependent gut immune response to bacterial uracil; required for the activation of Cad99C and consequently Cad99C-dependent endosome formation, which is essential for the Duox-dependent product [...] | 0.999 |
inaD | rdgA | FBpp0293662 | FBpp0305778 | Inactivation-no-after-potential D protein; Involved in the negative feedback regulation of the light- activated signaling cascade in photoreceptors through a calcium- mediated process. Interacts with tetrapeptide ligand located in C- terminal sequence of 3 key components of the visual cascade, tethering them and forming a macromolecular signaling phototransduction complex. | Retinal degeneration A (rdgA) encodes a diacylglycerol kinase that mediates the conversion of diacylglycerol to phosphatidic acid. It contributes to phospholipase C based signalling reactions, controlling ion channel activity and protein transport. | 0.733 |
inaD | rdgB | FBpp0293662 | FBpp0304106 | Inactivation-no-after-potential D protein; Involved in the negative feedback regulation of the light- activated signaling cascade in photoreceptors through a calcium- mediated process. Interacts with tetrapeptide ligand located in C- terminal sequence of 3 key components of the visual cascade, tethering them and forming a macromolecular signaling phototransduction complex. | Retinal degeneration B (rdgB) encodes a member of the Class IIA Phosphatidylinositol transfer protein (PITP) family. It supports multiple biochemical functions involving lipid transfer during G-protein coupled phospholipase C activation. | 0.476 |
inaD | trpl | FBpp0293662 | FBpp0087557 | Inactivation-no-after-potential D protein; Involved in the negative feedback regulation of the light- activated signaling cascade in photoreceptors through a calcium- mediated process. Interacts with tetrapeptide ligand located in C- terminal sequence of 3 key components of the visual cascade, tethering them and forming a macromolecular signaling phototransduction complex. | Transient-receptor-potential-like protein; A light-sensitive calcium channel that is required for inositide-mediated Ca(2+) entry in the retina during phospholipase C (PLC)-mediated phototransduction. Required for vision in the dark and in dim light. Binds calmodulin. Trp and trpl act together in the light response, although it is unclear whether as heteromultimers or distinct units. Also forms a functional cation channel with Trpgamma. Activated by fatty acids, metabolic stress, inositols and GTP-binding proteins. | 0.999 |
inaE | Arr2 | FBpp0288741 | FBpp0076326 | Inactivation no afterpotential E (inaE) encodes a diacylglycerol lipase involved in phototransduction and response to oxidative stress. | Phosrestin-1; Arrestin 2 (Arr2) encodes a protein involved in rhodopsin inactivation that contributes to photoreceptor maintenance and smell and sound perception. | 0.541 |
inaE | CG11029 | FBpp0288741 | FBpp0078767 | Inactivation no afterpotential E (inaE) encodes a diacylglycerol lipase involved in phototransduction and response to oxidative stress. | MIP29934p; Phospholipase activity. It is involved in the biological process described with: phospholipid metabolic process. | 0.669 |