STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Ir94eIonotropic receptor 94e; Ligand-gated ion channel activity. It is involved in the biological process described with: detection of chemical stimulus. (611 aa)    
Predicted Functional Partners:
Ir7e
Ionotropic receptor 7e; Ligand-gated ion channel activity. It is involved in the biological process described with: detection of chemical stimulus.
      
 0.791
Ir7b
Ionotropic receptor 7b; Ligand-gated ion channel activity. It is involved in the biological process described with: detection of chemical stimulus.
   
  
 0.681
Gr66a
Gustatory receptor for bitter taste 66a; Gustatory receptor required for response to the bitter in taste neurons. Gr66a cells respond to bitter compounds such as caffeine, theophylline, threonine or valine. Flies avoid bitter substances, suggesting that Gr66a neuron activity is sufficient to mediate avoidance behavior. Required for sensing and avoiding N,N- Diethyl-meta-toluamide (DEET), the most widely used insect repellent worldwide, as well as to L-canavanine, a plant-derived insecticide. Gr66a neurons are also involved in the sex-specific perception of molecules inducing male avoid [...]
   
  
 0.679
Ir7g
Ionotropic receptor 7g.
      
 0.669
Gr64f
Gustatory receptor for sugar taste 64f; One of the few identified sugar gustatory receptors identified so far and which promotes the starvation-induced increase of feeding motivation. Required in combination with Gr64a to detect sucrose, maltose, and glucose.
      
 0.669
Ir76b
Ionotropic receptor 76b (Ir76b) encodes a member of the Ionotropic Receptor (IR) family of variant ionotropic glutamate receptors. It functions in chemosensory detection of various amines and salt, as a probable co-receptor subunit.
      
 0.664
ppk23
Pickpocket 23 (ppk23) encodes a gustatory-specific putative non-voltage gated cation channel that belongs to the Degenerin/Epithelial sodium channel (DEG/ENaC) family. It contributes to pheromone perception and male courtship behavior.
   
  
 0.656
ppk28
Pickpocket protein 28; Osmosensitive ion channel that mediates the cellular and behavioral response to water. Plays an essential role in gustatory water reception. Part of a complex that plays a role in tracheal liquid clearance. Probable role in sodium transport. Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.
      
 0.655
Ir7a
Ionotropic receptor 7a; Ligand-gated ion channel activity. It is involved in the biological process described with: detection of chemical stimulus involved in sensory perception of bitter taste; sensory perception of taste; detection of chemical stimulus.
      
 0.604
OtopLc
Proton channel OtopLc; Proton-selective channel that specifically transports protons into cells. Proton-selective channel activity is probably required in cell types that use changes in intracellular pH for cell signaling or to regulate biochemical or developmental processes.
   
  
 0.603
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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