STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurrence
Coexpression
Experiments
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Textmining
[Homology]
Score
frcUDP-sugar transporter UST74c; Involved in the import of UDP-sugars from the cytoplasm into the Golgi lumen; Belongs to the TPT transporter family. SLC35D subfamily. (373 aa)    
Predicted Functional Partners:
sll
Slalom (sll) encodes the first transporter of 3'-phosphoadenosine 5'-phosphosulfate (PAPS), that transfers PAPS from cytosol into the lumen of Golgi. It contributes to the sulfation of glycans and proteins, the regulation of several signaling pathways (Hh, Wingless) mediated by glycosaminoglycans during patterning and morphogenesis, and the determination of the embryonic dorsal/ventral axis; Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.
   
  
 0.921
Efr
UDP-xylose and UDP-N-acetylglucosamine transporter; Sugar transporter that specifically mediates the transport of UDP-N-acetylglucosamine (UDP-GlcNAc), GDP-fucose and UDP-xylose. Functions redundantly with nac in the O-fucosylation of Notch, positively regulating Notch signaling. Involved in the biosynthesis of heparan sulfate-glycosaminoglycan (HS-GAG) and in Dpp signaling in the wing imaginal disk; Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.
   
  
 0.904
Coq4
Ubiquinone biosynthesis protein COQ4 homolog, mitochondrial; Component of the coenzyme Q biosynthetic pathway. May play a role in organizing a multi-subunit COQ enzyme complex required for coenzyme Q biosynthesis. Required for steady-state levels of other COQ polypeptides.
 
 
    0.900
CG14511
IP10585p; Transmembrane transporter activity; UDP-N-acetylglucosamine transmembrane transporter activity; UDP-xylose transmembrane transporter activity. It is involved in the biological process described with: transmembrane transport.
   
  
 0.878
senju
UDP-galactose transporter senju; UDP-galactose transporter involved in the synthesis of galactose-containing glycans. Plays a role in quiescence of the innate immune response, possibly by regulating glycosylation of the Toll pathway ligand spz.
   
  
 0.836
meigo
Solute carrier family 35 member B1 homolog; Medial glomeruli (meigo) encodes an evolutionarily conserved, multi-membrane pass protein that is mainly localized at the endoplasmic reticulum. meigo genetically interacts with Ephrin in dendrite targeting of olfactory projection neurons.
   
  
 0.726
Ugalt
UDP-galactose transporter, isoform B; UDP-galactose transporter (Ugalt) encodes a transporter involved in UDP-N-acetylgalactosamine, UDP-galactose and galactose transmembrane transport.
   
  
 0.693
nac
GDP-fucose transporter 1; Involved in GDP-fucose import from the cytoplasm into the Golgi lumen. Plays a major role in the fucosylation of N-glycans. Functions redundantly with Efr in the O-fucosylation of Notch, positively regulating Notch signaling; Belongs to the TPT transporter family. SLC35C subfamily.
   
  
0.690
beta4GalT7
Beta-4-galactosyltransferase 7 (beta4GalT7) encodes an enzyme that transfers a Gal to the Xyl-O-Ser in the tetrasaccharide structure of the protein-linkage region of glycosaminoglycans (GAGs). It is involved in Hh and Dpp signaling pathways mediated by GAGs in development.
   
  
 0.668
CG14971
FI19868p1; Transmembrane transporter activity; antiporter activity. It is involved in the biological process described with: UDP-glucose transmembrane transport.
   
  
 0.651
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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