STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
brv3Brivido-3, isoform C; Calcium ion binding; calcium channel activity. It is involved in the biological process described with: calcium ion transport; detection of mechanical stimulus; response to cold. (750 aa)    
Predicted Functional Partners:
CG14142
Uncharacterized protein, isoform B; Cysteine-type carboxypeptidase activity; Lys48-specific deubiquitinase activity.
      
 0.790
GlcAT-P
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase P; Involved in the biosynthesis of L2/HNK-1 carbohydrate epitope on both glycolipids and glycoproteins. Enzyme has a broad specificity.
      
 0.606
Plod
Procollagen-lysine,2-oxoglutarate 5-dioxygenase; Procollagen lysyl hydroxylase (Plod) encodes a lysyl dehydrogenase with roles in Collagen IV biosynthesis. It localizes to the endoplasmic reticulum and is required for the secretion Collagen IV from haemocytes and fat body.
      
 0.497
CG42685
PLAT domain-containing protein.
   
 
 0.497
PRY
Polycystin-related Y protein.
    
 
 0.494
smp-30
Senescence marker protein-30 (smp-30) encodes a calcium binding protein involved in calcium homeostasis regulation. It negatively influences cell proliferation and tissue size, possibly through the insulin pathway. It contributes to body size variation, diapause and thermal stress resistance.
      
 0.493
CG11226
AT16729p.
   
  
 0.432
NC2beta
Protein Dr1; Bifunctional basic transcription factor. Activates transcription of DPE (Downstream Promoter Element) containing promoters while repressing transcription of promoters which contain TATA elements. Together with Chrac-14, promotes nucleosome sliding of ATP-dependent nucelosome remodeling complexes. Belongs to the NC2 beta/DR1 family.
      
 0.430
tal-1A
Tarsal-less 1A (tal-1A) encodes one of four open reading frames within the tal polycistronic transcription unit. The encoded peptide controls the post-transcriptional activation of the product of ovo, which in turn regulates Notch signalling and F-actin organization.
      
 0.426
whe
What else, isoform A.
      
 0.422
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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