STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Spn47CSerpin 47C, isoform A; Serine-type endopeptidase inhibitor activity. It is involved in the biological process described with: multicellular organism reproduction; negative regulation of endopeptidase activity; Belongs to the serpin family. (382 aa)    
Predicted Functional Partners:
Spn85F
Serpin 85F; Serine-type endopeptidase inhibitor activity. It is involved in the biological process described with: negative regulation of endopeptidase activity; Belongs to the serpin family.
     
 0.789
Spn77Bb
Serpin 77Bb; Serine-type endopeptidase inhibitor activity. It is involved in the biological process described with: negative regulation of endopeptidase activity; multicellular organism reproduction; Belongs to the serpin family.
  
 
0.644
Spn75F
Male accessory gland protein; Serine-type endopeptidase inhibitor activity. It is involved in the biological process described with: negative regulation of endopeptidase activity; multicellular organism reproduction; Belongs to the serpin family.
  
 
0.634
Spn77Ba
Serine protease inhibitor 77Ba; Serine protease inhibitor which plays an essential role in regulating the tracheal melanization immune response to bacterial and fungal infection. Acts by negatively regulating a protease cascade involving Mp1 and Sp7, that functions in the activation of the Hayan-phenoloxidase (PPO1) cascade ; Belongs to the serpin family.
  
 
0.633
Spn77Bc
Serpin 77Bc (Spn77Bc) encodes a protein produced by the male accessory glands and transferred to females during mating.
  
 
0.623
Spn43Ad
Serpin 43Ad; Serine-type endopeptidase inhibitor activity. It is involved in the biological process described with: negative regulation of endopeptidase activity; Belongs to the serpin family.
  
  
0.611
Spn31A
Serpin 31A; Serine-type endopeptidase inhibitor activity. It is involved in the biological process described with: negative regulation of endopeptidase activity; Belongs to the serpin family.
  
  
0.592
Spn28Dc
Serine protease inhibitor 28Dc; Serine protease inhibitor which is required for pupal viability and plays an essential role in regulating the melanization reaction. Inhibits spontaneous melanization and appears to be involved in the melanization immune response to physical wounding in larvae and adults. Acts by negatively regulating the Hayan-phenoloxidase (PPO1) cascade in the hemolymph and possibly the trachea. May function by controlling the initial release of the activated form of PPO1, phenoloxidase (PO) and thus maintains PO availability for processes such as wound response and p [...]
  
  
0.588
Spn88Eb
CG6687 protein; Serine-type endopeptidase inhibitor activity. It is involved in the biological process described with: response to fungus; negative regulation of endopeptidase activity; epithelium regeneration; regulation of stem cell division; negative regulation of proteolysis; Belongs to the serpin family.
  
  
0.579
Spn53F
Serpin 53F; Serine-type endopeptidase inhibitor activity. It is involved in the biological process described with: multicellular organism reproduction; negative regulation of endopeptidase activity; Belongs to the serpin family.
  
  
0.565
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.