STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
GyfGigyf (Gyf) encodes a protein that is necessary for maintenance of neuromuscular homeostasis. It regulates protein translation, insulin/IGF signaling pathway and autophagy. (1574 aa)    
Predicted Functional Partners:
me31B
ATP-dependent RNA helicase me31b; ATP-dependent RNA helicase which is a core component of a variety of ribonucleoprotein complexes (RNPs) that play critical roles in translational repression and mRNA decapping during embryogenesis, oogenesis, neurogenesis and neurotransmission. Recruits core components and translational repressors to some RNP complexes, and mediates RNP aggregation into processing granules such as P-bodies. As part of a RNP complex containing tral, eIF4E1, cup, and pAbp, involved in RNP-mediated translational repression of maternal mRNAs during oogenesis and embryogene [...]
   
 
 0.988
pico
Pico, isoform A; Pico (pico) encodes an intracellular adapter protein belonging to the MRL family of proteins, which transduce signals from growth factor receptors to changes in the actin cytoskeleton. Its roles include the regulation of growth and cell migration.
   
 
 0.952
eIF4EHP
Eukaryotic translation initiation factor 4E homologous protein (eIF4EHP) encodes a protein that binds the 7-methyl-guanosine cap structure of mRNA and functions as a negative regulator of translation. The product of eIF4EHP contributes to embryonic patterning by negatively regulating translation of the products of cad and hb, and is also implicated in regulating ecdysone biosynthesis.
   
 0.948
eIF4G1
Eukaryotic translation initiation factor 4G1 (eIF4G1) encodes a protein that contributes to translation and spermatogenesis.
   
 
 0.913
gw
Protein Gawky; Required for gene silencing mediated by micro-RNAs (miRNAs). Silences both polyadenylated and deadenylated mRNAs. Required for miRNA-mediated translational repression and mRNA decay. Not required for miRNA target recognition. Necessary to initiate but not to maintain silencing. Promotes mRNA deadenylation through the recruitment of the CCR4-NOT and PAN complexes and promotes decapping by the DCP1-DCP2 complex. Dissociates from silenced mRNAs after deadenylation. Required for completion of nuclear divisions during early embryonic development. Belongs to the GW182 family.
   
 
 0.911
eIF4E1
Eukaryotic translation initiation factor 4E1; Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. In 0-1 hour embryos, forms a complex with me31B, cup, tral and pAbp which binds to various mRNAs including maternal mRNAs, and downregulates their expression during the maternal-to-zygotic transition. Belongs to the eukaryotic initiation factor 4E family.
   
 0.879
eIF4E7
Eukaryotic translation initiation factor 4E7 (eIF4E7) encodes a protein involved in translational initiation.
    
 0.876
eIF4E3
Eukaryotic translation initiation factor 4E3 (eIF4E3) encodes a protein that binds the 7-methyl-guanosine cap structure of mRNA. It is a component of the eIF4F cap-binding complex that is essential for cap-dependent translation of mRNA. eIF4E3 is primarily expressed in testes and is required for male fertility, but not for viability.
    
 0.876
eIF4E5
Eukaryotic translation initiation factor 4E5 (eIF4E5) encodes a protein in translational initiation.
    
 0.876
eIF4E4
Eukaryotic translation initiation factor 4E4 (eIF4E4) encodes a protein involved in translational initiation.
    
 0.876
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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