STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
meshProtein mesh; Required, together with Ssk and Tsp2A, for the proper organization of smooth septate junctions (sSJs), probably by mediating cell adhesion via its homophilic interaction. Also required for the correct subcellular localization of several sSJ components, such as Ssk, cora and l(2)gl, and for the barrier function of the midgut epithelium. Required for maintaining the three-layered structure of the proventriculus. (1454 aa)    
Predicted Functional Partners:
Ssk
Protein snakeskin; Required for assembly of smooth septate junctions (sSJs), together with mesh and Tsp2A. May be important for barrier function of the midgut epithelium.
   
 
 0.649
RpS30
40S ribosomal protein S30; Structural constituent of ribosome. It is involved in the biological process described with: translation; cytoplasmic translation; Belongs to the eukaryotic ribosomal protein eS30 family.
      
 0.535
Decay
Death executioner caspase related to Apopain/Yama (Decay) encodes one of the seven members of the caspase family of cysteine proteases. It has substrate specificity similar to the effector caspases encoded by Drice and Dcp-1; Belongs to the peptidase C14A family.
   
    0.497
Vha100-5
V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.
   
    0.497
CG9380
MIP09469p.
   
    0.489
stl
Stall, isoform C; Stall (stl) encodes a protein involved in neuron migration inhibition and ovarian follicle development.
   
  
 0.474
Oatp33Eb
Organic anion transporting polypeptide 33Eb; Sodium-independent organic anion transmembrane transporter activity; transmembrane transporter activity; active transmembrane transporter activity. It is involved in the biological process described with: organic substance transport; sodium-independent organic anion transport; transmembrane transport.
   
  
 0.465
kst
Karst, isoform E; Karst (kst) encodes a protein that, together with the product of alpha-Spec, crosslinks F-actin and acts as a molecular scaffold. It is recruited to the apical membrane of epithelial cells by the apical determinant encoded by crb. The roles of the product of kst include endosomal trafficking, cell adhesion, cell signaling and growth control.
   
  
 0.453
CG32454
AMP_N domain-containing protein; Aminopeptidase activity; manganese ion binding.
      
 0.441
CG9581
GH19483p; Peptidase activity; aminopeptidase activity; manganese ion binding.
      
 0.434
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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