STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
appApproximated (app) encodes a palmitoyltransferase involved in planar cell polarity. It regulates Fat signaling and the localization and activity of the product of d; Belongs to the DHHC palmitoyltransferase family. ERF2/ZDHHC9 subfamily. (755 aa)    
Predicted Functional Partners:
CG5447
Uncharacterized protein, isoform B; Protein-cysteine S-palmitoyltransferase activity. It is involved in the biological process described with: Golgi to plasma membrane protein transport; peptidyl-L-cysteine S-palmitoylation; protein targeting to membrane.
    
 0.939
CG13654
Uncharacterized protein, isoform A.
   
  
 0.834
Dlish
Dachs ligand with SH3s (Dlish) encodes an adapter protein that can bind to the products of d, ds, and ft. It is required for the normal growth of wings and legs via Dachsous-Fat signaling.
    
 
 0.815
AANATL7
Arylalkylamine N-acetyltransferase-like 7, isoform A; N-acetyltransferase activity.
      
 0.795
AgmNAT
N-acetyltransferase activity.
      
 0.791
Ras85D
Ras-like protein 1; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity (By similarity). Plays a role in eye development by regulating cell growth, survival of postmitotic ommatidial cells and differentiation of photoreceptor cells. During larval development, mediates Ptth/tor signaling leading to the production of ecdysone, a hormone required for the initiation of metamorphosis.
    
 0.784
CG43902
Uncharacterized protein; RNA binding; histone binding; chromatin binding. It is involved in the biological process described with: chromatin remodeling.
    
 
 0.622
Fign
Fidgetin-like protein 1; ATP binding; magnesium ion binding; ATPase activity; microtubule-severing ATPase activity; hydrolase activity.
   
  
 0.534
d
Dachs, isoform E; Dachs (d) encodes a myosin family protein that participates in Dachsous-Fat signaling, which polarizes its localization. It influences planar cell polarity, partly through interaction with the product of pk, and growth, through interaction with the product of wts; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
    
 
 0.530
ste14
Protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity. It is involved in the biological process described with: C-terminal protein methylation.
    
 
 0.523
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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