node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
4E-T | fuss | FBpp0088297 | FBpp0306687 | eIF4E-Transporter, isoform B; eIF4E-Transporter (4E-T) encodes a large protein that interacts with regulators of translation and mRNA stability, including CNOT1 and LSM14 as well as the products of me31B and eIF4E1. Levels of the 4E-T product are particularly high in germ cells and early development when translational control predominates in gene regulation. | Fussel, isoform B; Fussel (fuss) encodes a protein that belongs to the highly conserved Sno/Ski family of Smad binding proteins. fuss mutant phenotypes in the larval brain phenocopy babo and Smox mutants, suggesting a role in Activin signaling. fuss overexpression antagonizes both Dpp and Activin signaling. | 0.603 |
BTBD9 | fuss | FBpp0306532 | FBpp0306687 | BTB/POZ domain-containing protein 9; Essential for the homeostatic regulation of sleep and motor activity, by depressing hyperactivity and wakefulness. May function, at least in part, by ensuring dopamine biosynthesis. | Fussel, isoform B; Fussel (fuss) encodes a protein that belongs to the highly conserved Sno/Ski family of Smad binding proteins. fuss mutant phenotypes in the larval brain phenocopy babo and Smox mutants, suggesting a role in Activin signaling. fuss overexpression antagonizes both Dpp and Activin signaling. | 0.712 |
CG16815 | fuss | FBpp0271956 | FBpp0306687 | Uncharacterized protein. | Fussel, isoform B; Fussel (fuss) encodes a protein that belongs to the highly conserved Sno/Ski family of Smad binding proteins. fuss mutant phenotypes in the larval brain phenocopy babo and Smox mutants, suggesting a role in Activin signaling. fuss overexpression antagonizes both Dpp and Activin signaling. | 0.608 |
CG31624 | fuss | FBpp0310410 | FBpp0306687 | Uncharacterized protein, isoform A; Transcription coregulator activity. | Fussel, isoform B; Fussel (fuss) encodes a protein that belongs to the highly conserved Sno/Ski family of Smad binding proteins. fuss mutant phenotypes in the larval brain phenocopy babo and Smox mutants, suggesting a role in Activin signaling. fuss overexpression antagonizes both Dpp and Activin signaling. | 0.602 |
Nedd8 | fuss | FBpp0309711 | FBpp0306687 | NEDD8; Ubiquitin-like protein which plays an important role in cell cycle control, embryogenesis and neurogenesis. Covalent attachment to its substrates requires prior activation by the E1 complex Uba3-Ula1 and linkage to the E2 enzyme UbcE2M. Attachment of Nedd8 to cullins activates their associated E3 ubiquitin ligase activity, and thus promotes polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins. | Fussel, isoform B; Fussel (fuss) encodes a protein that belongs to the highly conserved Sno/Ski family of Smad binding proteins. fuss mutant phenotypes in the larval brain phenocopy babo and Smox mutants, suggesting a role in Activin signaling. fuss overexpression antagonizes both Dpp and Activin signaling. | 0.606 |
Nedd8 | ubl | FBpp0309711 | FBpp0085529 | NEDD8; Ubiquitin-like protein which plays an important role in cell cycle control, embryogenesis and neurogenesis. Covalent attachment to its substrates requires prior activation by the E1 complex Uba3-Ula1 and linkage to the E2 enzyme UbcE2M. Attachment of Nedd8 to cullins activates their associated E3 ubiquitin ligase activity, and thus promotes polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins. | Ubiquitin-like protein 5; Protein tag. It is involved in the biological process described with: mRNA splicing, via spliceosome; cellular protein modification process. | 0.979 |
dve | fuss | FBpp0071689 | FBpp0306687 | Defective proventriculus (dve) encodes a transcriptional repressor that binds to the K50 site. It is involved in developmental patterning, cell-type specification, and functional differentiation. | Fussel, isoform B; Fussel (fuss) encodes a protein that belongs to the highly conserved Sno/Ski family of Smad binding proteins. fuss mutant phenotypes in the larval brain phenocopy babo and Smox mutants, suggesting a role in Activin signaling. fuss overexpression antagonizes both Dpp and Activin signaling. | 0.603 |
dve | ubl | FBpp0071689 | FBpp0085529 | Defective proventriculus (dve) encodes a transcriptional repressor that binds to the K50 site. It is involved in developmental patterning, cell-type specification, and functional differentiation. | Ubiquitin-like protein 5; Protein tag. It is involved in the biological process described with: mRNA splicing, via spliceosome; cellular protein modification process. | 0.790 |
fd102C | fuss | FBpp0088311 | FBpp0306687 | Forkhead domain 102C; DNA-binding transcription factor activity, RNA polymerase II-specific; sequence-specific DNA binding. It is involved in the biological process described with: cell differentiation; regulation of transcription by RNA polymerase II; anatomical structure morphogenesis. | Fussel, isoform B; Fussel (fuss) encodes a protein that belongs to the highly conserved Sno/Ski family of Smad binding proteins. fuss mutant phenotypes in the larval brain phenocopy babo and Smox mutants, suggesting a role in Activin signaling. fuss overexpression antagonizes both Dpp and Activin signaling. | 0.665 |
fuss | 4E-T | FBpp0306687 | FBpp0088297 | Fussel, isoform B; Fussel (fuss) encodes a protein that belongs to the highly conserved Sno/Ski family of Smad binding proteins. fuss mutant phenotypes in the larval brain phenocopy babo and Smox mutants, suggesting a role in Activin signaling. fuss overexpression antagonizes both Dpp and Activin signaling. | eIF4E-Transporter, isoform B; eIF4E-Transporter (4E-T) encodes a large protein that interacts with regulators of translation and mRNA stability, including CNOT1 and LSM14 as well as the products of me31B and eIF4E1. Levels of the 4E-T product are particularly high in germ cells and early development when translational control predominates in gene regulation. | 0.603 |
fuss | BTBD9 | FBpp0306687 | FBpp0306532 | Fussel, isoform B; Fussel (fuss) encodes a protein that belongs to the highly conserved Sno/Ski family of Smad binding proteins. fuss mutant phenotypes in the larval brain phenocopy babo and Smox mutants, suggesting a role in Activin signaling. fuss overexpression antagonizes both Dpp and Activin signaling. | BTB/POZ domain-containing protein 9; Essential for the homeostatic regulation of sleep and motor activity, by depressing hyperactivity and wakefulness. May function, at least in part, by ensuring dopamine biosynthesis. | 0.712 |
fuss | CG16815 | FBpp0306687 | FBpp0271956 | Fussel, isoform B; Fussel (fuss) encodes a protein that belongs to the highly conserved Sno/Ski family of Smad binding proteins. fuss mutant phenotypes in the larval brain phenocopy babo and Smox mutants, suggesting a role in Activin signaling. fuss overexpression antagonizes both Dpp and Activin signaling. | Uncharacterized protein. | 0.608 |
fuss | CG31624 | FBpp0306687 | FBpp0310410 | Fussel, isoform B; Fussel (fuss) encodes a protein that belongs to the highly conserved Sno/Ski family of Smad binding proteins. fuss mutant phenotypes in the larval brain phenocopy babo and Smox mutants, suggesting a role in Activin signaling. fuss overexpression antagonizes both Dpp and Activin signaling. | Uncharacterized protein, isoform A; Transcription coregulator activity. | 0.602 |
fuss | Nedd8 | FBpp0306687 | FBpp0309711 | Fussel, isoform B; Fussel (fuss) encodes a protein that belongs to the highly conserved Sno/Ski family of Smad binding proteins. fuss mutant phenotypes in the larval brain phenocopy babo and Smox mutants, suggesting a role in Activin signaling. fuss overexpression antagonizes both Dpp and Activin signaling. | NEDD8; Ubiquitin-like protein which plays an important role in cell cycle control, embryogenesis and neurogenesis. Covalent attachment to its substrates requires prior activation by the E1 complex Uba3-Ula1 and linkage to the E2 enzyme UbcE2M. Attachment of Nedd8 to cullins activates their associated E3 ubiquitin ligase activity, and thus promotes polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins. | 0.606 |
fuss | dve | FBpp0306687 | FBpp0071689 | Fussel, isoform B; Fussel (fuss) encodes a protein that belongs to the highly conserved Sno/Ski family of Smad binding proteins. fuss mutant phenotypes in the larval brain phenocopy babo and Smox mutants, suggesting a role in Activin signaling. fuss overexpression antagonizes both Dpp and Activin signaling. | Defective proventriculus (dve) encodes a transcriptional repressor that binds to the K50 site. It is involved in developmental patterning, cell-type specification, and functional differentiation. | 0.603 |
fuss | fd102C | FBpp0306687 | FBpp0088311 | Fussel, isoform B; Fussel (fuss) encodes a protein that belongs to the highly conserved Sno/Ski family of Smad binding proteins. fuss mutant phenotypes in the larval brain phenocopy babo and Smox mutants, suggesting a role in Activin signaling. fuss overexpression antagonizes both Dpp and Activin signaling. | Forkhead domain 102C; DNA-binding transcription factor activity, RNA polymerase II-specific; sequence-specific DNA binding. It is involved in the biological process described with: cell differentiation; regulation of transcription by RNA polymerase II; anatomical structure morphogenesis. | 0.665 |
fuss | rasp | FBpp0306687 | FBpp0072893 | Fussel, isoform B; Fussel (fuss) encodes a protein that belongs to the highly conserved Sno/Ski family of Smad binding proteins. fuss mutant phenotypes in the larval brain phenocopy babo and Smox mutants, suggesting a role in Activin signaling. fuss overexpression antagonizes both Dpp and Activin signaling. | Protein-cysteine N-palmitoyltransferase Rasp; Required in hedgehog (hh) expressing cells for production of appropriate signaling activity in embryos and in the imaginal precursors of adult tissues. Acts within the secretory pathway to catalyze N-terminal palmitoylation of Hh; this lipid modification is required for the embryonic and larval patterning activities of the Hh signal. Not required for Wg signaling. | 0.669 |
fuss | ubl | FBpp0306687 | FBpp0085529 | Fussel, isoform B; Fussel (fuss) encodes a protein that belongs to the highly conserved Sno/Ski family of Smad binding proteins. fuss mutant phenotypes in the larval brain phenocopy babo and Smox mutants, suggesting a role in Activin signaling. fuss overexpression antagonizes both Dpp and Activin signaling. | Ubiquitin-like protein 5; Protein tag. It is involved in the biological process described with: mRNA splicing, via spliceosome; cellular protein modification process. | 0.602 |
fuss | unc79 | FBpp0306687 | FBpp0290907 | Fussel, isoform B; Fussel (fuss) encodes a protein that belongs to the highly conserved Sno/Ski family of Smad binding proteins. fuss mutant phenotypes in the larval brain phenocopy babo and Smox mutants, suggesting a role in Activin signaling. fuss overexpression antagonizes both Dpp and Activin signaling. | Uncoordinated 79 (unc79) encodes a protein involved in circadian locomotor rhythms. | 0.608 |
rasp | fuss | FBpp0072893 | FBpp0306687 | Protein-cysteine N-palmitoyltransferase Rasp; Required in hedgehog (hh) expressing cells for production of appropriate signaling activity in embryos and in the imaginal precursors of adult tissues. Acts within the secretory pathway to catalyze N-terminal palmitoylation of Hh; this lipid modification is required for the embryonic and larval patterning activities of the Hh signal. Not required for Wg signaling. | Fussel, isoform B; Fussel (fuss) encodes a protein that belongs to the highly conserved Sno/Ski family of Smad binding proteins. fuss mutant phenotypes in the larval brain phenocopy babo and Smox mutants, suggesting a role in Activin signaling. fuss overexpression antagonizes both Dpp and Activin signaling. | 0.669 |