STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CG8478Uncharacterized protein, isoform D; DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding; RNA polymerase II regulatory region sequence-specific DNA binding; sequence-specific DNA binding. It is involved in the biological process described with: regulation of transcription by RNA polymerase II. (576 aa)    
Predicted Functional Partners:
msb1l
LD32040p.
   
  
 0.836
CycB3
G2/mitotic-specific cyclin-B3; Cyclins are positive regulatory subunits of the cyclin- dependent kinases (CDKs), and thereby play an essential role in the control of the cell cycle, notably via their destruction during cell division. Probably functions redundantly with other cyclins in regulation of cell cycle. Its presence may be required to delay a deadline for completing cytokinesis that is ordinary imposed by nuclear envelope reformation. Degradation of CycB and CycB3 promote cytokinesis furrow initiation and ingression. Required with CycB for female fertility.
   
  
 0.812
polo
Serine/threonine-protein kinase polo; May play a role in regulating both nuclear and cytoplasmic aspects of the mitotic cycle. Regulates localization of the augmin complex during mitosis by ensuring its location on mitotic spindles. Also regulates augmin complex localization during male meiosis by promoting its placement at kinetochores while preventing its association with spindle microtubules ; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily.
   
  
 0.725
CG31639
GEO13064p1.
      
 0.670
BCL7-like
BCL7-like protein.
   
  
 0.641
CG15141
LD24839p; Zinc ion binding; ubiquitin protein ligase activity.
   
  
 0.611
Incenp
Inner centromere protein (Incenp) encodes a component of the chromosomal passenger complex, acting as a subunit that targets and activates the product of aurB. It controls different processes during cell division, including regulation of chromosome structure, kinetochore-microtubule error correction, chromosome segregation and cytokinesis.
   
  
 0.595
Chrac-16
Chromatin accessibility complex 16kD protein; Histone-like protein which promotes nucleosome sliding of ATP-dependent nucleosome remodeling complexes. Part of the chromatin-accessibility complex (CHRAC) which uses energy/ATP to increase the general accessibility of DNA in chromatin. As an heterodimer with Chrac-14, binds DNA and facilitates nucleosome sliding by Acf. As part of the CHRAC complex, required for oogenesis.
   
  
 0.552
kuk
Kugelkern, isoform A; Kugelkern (kuk) encodes a nuclear envelope protein required for nuclear elongation during cellularization. It shares structural and functional similarities to lamins.
   
  
 0.544
mei-S332
Shugoshin; Plays a central role in chromosome cohesion during meiosis and mitosis by preventing premature dissociation of cohesin complex from centromeres after prophase, when most of cohesin complex dissociates from chromosomes arms. May act by protecting or Rad21 from cleavage by Sse/separase. Required during meiosis in both males and females.
   
  
 0.544
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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