STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
nabNGFI-A-binding protein homolog; Transcriptional regulator that can both act as a coactivator or a corepressor depending on the context. Lacks DNA-binding domains and acts by associating with other transcription factors such as rotund (rn) and squeeze (sqz). Acts as a coactivator of sqz and is required to limit the number of neurons that express the LIM-homeodomain gene apterous and to specify Tv neuronal fate. Acts as corepressor of rn in wing development and is required to limit the expression of wingless (wg) in the wing hinge, where wg plays a mitogenic role. Belongs to the NAB family. (625 aa)    
Predicted Functional Partners:
sr
Stripe, isoform D; Stripe (sr) encodes a transcription factor that induces the fate of tendon cells in the embryo as well as in the adult fly. It works upstream of tendon specific genes including Tsp, slow and Lrt.
    
 0.812
sqz
Zinc finger protein squeeze; Transcription factor involved in neuronal fate specification. First required in embryonic CNS development to define the number of cells that express apterous (ap) in the ap thoracic cluster of interneurons. Later on, it plays a central role in the combinatorial code of transcription factors that specifies the fate of the Tv neuron in the ap cluster by participating in the transcription regulation of FMRFa in Tv cells. Also required for projection neuron dendritic targeting.
    
 
 0.730
Cdc45
CDC45L (CDC45L) encodes a protein that contributes to 3'-5' DNA helicase activity of the Cdc45/Mcm2-7/GINS complex. It is involved in chromosome condensation and the regulation of the mitotic G1/S transition.
      
 0.669
Mcm10
Protein MCM10 homolog; Proposed to be involved in DNA replication and to participate in the activation of the pre-replication complex (pre-RC). May be involved in chromosome condensation.
      
 0.662
Ctf4
Chromosome transmission fidelity 4; Chromatin binding.
      
 0.628
Sld5
Sld5 (Sld5) encodes a subunit of the Cdc45/Mcm2-7/GINS (CMG) complex, which is associated with an ATP-dependent DNA helicase function and is involved in the regulation of the mitotic G1/S transition.
      
 0.625
dup
Double parked (dup) encodes an essential protein for the initiation of DNA replication due to its recruitment of the MCM helicase to replication origins.
      
 0.606
Cdc6
Cell division control protein; Cdc6 (Cdc6) encodes an essential component of the pre-Replication complex (preRC) together with the origin recognition complex, the product of dup and MCM2-7 proteins. The preRC is present at all chromosomal origins of replication and is required for the initiation of DNA replication. The product of Cdc6 also functions in the co-ordination of DNA replication with mitosis, and may contribute to apoptosis and transcription; Belongs to the CDC6/cdc18 family.
      
 0.605
FBgn0264326
DNA polymerase epsilon catalytic subunit 1; Catalytic component of the DNA polymerase epsilon complex. Participates in chromosomal DNA replication. Required during synthesis of the leading DNA strands at the replication fork, binds at/or near replication origins and moves along DNA with the replication fork (By similarity). Has 3'-5' proofreading exonuclease activity that corrects errors arising during DNA replication. Has a role in the G1-S transition and/or S-phase progression of the mitotic cycle and endocycle progression. Involved in DNA synthesis during DNA repair (By similarity). [...]
      
 0.601
Mcm5
DNA replication licensing factor Mcm5; Acts as component of the Mcm2-7 complex (Mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the Mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]
      
 0.600
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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