STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
GabatGamma-aminobutyric acid transaminase (Gabat) encodes an enzyme involved in the breakdown of the sleep-promoting neurotransmitter gamma-aminobutyric (GABA). It functions in mitochondria, in a shunt of the TCA cycle, and is implicated in the regulation of sleep as well as in metabolism; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (486 aa)    
Predicted Functional Partners:
Ssadh
Succinate-semialdehyde dehydrogenase (NAD+) activity; succinate-semialdehyde dehydrogenase [NAD(P)+] activity. It is involved in the biological process described with: oxidation-reduction process; gamma-aminobutyric acid catabolic process.
  
 0.976
CG17896
Probable methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial; Plays a role in valine and pyrimidine metabolism. Binds fatty acyl-CoA (By similarity).
   
 
 0.965
Aldh-III
Aldehyde dehydrogenase type III (Aldh-III) encodes a protein that confers a xenobiotic stress resistance by oxidising aromatic aldehydes (benzaldehyde). It also neutralises the lipid aldehydes formed after the attack of reactive oxygen and radicals, such as malondialdehyde during lipid peroxidation. The catalytic redox reaction uses NAD(P)+ as a cofactor.
  
 0.952
Gad1
Glutamic acid decarboxylase 1 (Gad1) encodes an essential, nervous system-specific glutamic acid decarboxylase, which is the synthetic enzyme for the major inhibitory neurotransmitter gamma-Aminobutyric acid (GABA). It is required for a multitude of physiological functions and adult behaviors dependent on GABA, including sleep, memory, circadian rhythms and egg hatching; Belongs to the group II decarboxylase family.
  
 0.941
Aldh
Aldehyde dehydrogenase (Aldh) encodes an NAD[+] dependent mitochondrial aldehyde dehydrogenase. Its functions include detoxifying endogenous aldehydes generated by lipid peroxidation, and detoxifying acetaldehyde derived from dietary ethanol.
  
 0.941
CG11241
IP18034p; Pyridoxal phosphate binding; alanine-glyoxylate transaminase activity; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.
   
0.939
b
Black (b) encodes an aspartate 1-decarboxylase. Mutations of b result in viable flies with a cuticular melanization phenotype.
  
 0.938
CG31075
Uncharacterized protein, isoform B; Aldehyde dehydrogenase (NAD+) activity. It is involved in the biological process described with: oxidation-reduction process; pyruvate metabolic process.
  
 0.934
pyd3
Pyd3 (pyd3) encodes a beta-alanine synthase involved in pyrimidine catabolism, beta-alanine biosynthesis and cuticle pigmentation.
  
 
 0.933
Aldh7A1
Aldehyde dehydrogenase 7 family member A1; Oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor. It is involved in the biological process described with: oxidation-reduction process.
  
 0.931
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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