node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Cfp1 | Dpy-30L1 | FBpp0071262 | FBpp0079701 | CXXC-type zinc finger protein 1; Component of the SET1 complex that specifically di- and trimethylates 'Lys-4' of histone H3. Essential for Set1 association with chromatin and trimethylation of histone H3 at 'Lys-4' at transcription puffs. Additionally, is critical for general chromosomal association of Set1. | Dpy-30-like 1 (Dpy-30L1) encodes a protein that is part of the COMPASS complex, a histone H3K4 methyltransferase complex thought to be responsible for the bulk of the histone H3K4 di- and trimethylation. The product of Dpy-30L1 binds to, and thereby inhibits, the metal-responsive transcription factor encoded by MTF-1. | 0.974 |
Cfp1 | Dpy-30L2 | FBpp0071262 | FBpp0073137 | CXXC-type zinc finger protein 1; Component of the SET1 complex that specifically di- and trimethylates 'Lys-4' of histone H3. Essential for Set1 association with chromatin and trimethylation of histone H3 at 'Lys-4' at transcription puffs. Additionally, is critical for general chromosomal association of Set1. | Dpy-30-like 2 (Dpy-30L2) is expressed in elongated spermatids but not in early or mature sperm. Targeted disruption of the gene results in sperm motility impairment and male sterility. | 0.881 |
Cfp1 | Hcf | FBpp0071262 | FBpp0311451 | CXXC-type zinc finger protein 1; Component of the SET1 complex that specifically di- and trimethylates 'Lys-4' of histone H3. Essential for Set1 association with chromatin and trimethylation of histone H3 at 'Lys-4' at transcription puffs. Additionally, is critical for general chromosomal association of Set1. | HCF C-terminal chain; May be involved in control of the cell cycle. | 0.938 |
Cfp1 | Rbbp5 | FBpp0071262 | FBpp0077900 | CXXC-type zinc finger protein 1; Component of the SET1 complex that specifically di- and trimethylates 'Lys-4' of histone H3. Essential for Set1 association with chromatin and trimethylation of histone H3 at 'Lys-4' at transcription puffs. Additionally, is critical for general chromosomal association of Set1. | Retinoblastoma-binding protein 5 homolog; Component of the SET1 complex that specifically di- and trimethylates 'Lys-4' of histone H3 and of the MLL3/4 complex which also methylates histone H3 'Lys-4'. | 0.994 |
Cfp1 | Set1 | FBpp0071262 | FBpp0112593 | CXXC-type zinc finger protein 1; Component of the SET1 complex that specifically di- and trimethylates 'Lys-4' of histone H3. Essential for Set1 association with chromatin and trimethylation of histone H3 at 'Lys-4' at transcription puffs. Additionally, is critical for general chromosomal association of Set1. | Histone-lysine N-methyltransferase SETD1; Catalytic component of the SET1 complex that specifically di- and trimethylates 'Lys-4' of histone H3 and is the main di- and trimethyltransferase throughout development. Set1-dependent trimethylation regulates chromatin changes at active promoters that ensure optimal RNA polymerase II release into productive elongation, thereby contributing to optimal transcription. | 0.993 |
Cfp1 | Wdr82 | FBpp0071262 | FBpp0079266 | CXXC-type zinc finger protein 1; Component of the SET1 complex that specifically di- and trimethylates 'Lys-4' of histone H3. Essential for Set1 association with chromatin and trimethylation of histone H3 at 'Lys-4' at transcription puffs. Additionally, is critical for general chromosomal association of Set1. | WD repeat domain 82 (Wdr82) encodes a component of the Compass complex, which performs K4 methylation of the histone encoded by His3. | 0.982 |
Cfp1 | ash2 | FBpp0071262 | FBpp0084040 | CXXC-type zinc finger protein 1; Component of the SET1 complex that specifically di- and trimethylates 'Lys-4' of histone H3. Essential for Set1 association with chromatin and trimethylation of histone H3 at 'Lys-4' at transcription puffs. Additionally, is critical for general chromosomal association of Set1. | Set1/Ash2 histone methyltransferase complex subunit ASH2; Transcriptional regulator. Regulates a number of genes involved in wing development including activation of net and bs and repression of rho and kni and controls vein-intervein patterning during wing development. Required for correct expression of a number of homeotic genes including Scr in the first leg imaginal disk and Ubx in the third leg imaginal disk and haltere disks. Required for stabilization of the histone-lysine N-methyltransferase trr and for trimethylation of 'Lys-4' of histone H3. Plays a role in maintenance of tra [...] | 0.994 |
Cfp1 | wds | FBpp0071262 | FBpp0300790 | CXXC-type zinc finger protein 1; Component of the SET1 complex that specifically di- and trimethylates 'Lys-4' of histone H3. Essential for Set1 association with chromatin and trimethylation of histone H3 at 'Lys-4' at transcription puffs. Additionally, is critical for general chromosomal association of Set1. | Protein will die slowly; Contributes to histone modification. May position the N- terminus of histone H3 for efficient trimethylation at 'Lys-4'. | 0.961 |
Dpy-30L1 | Cfp1 | FBpp0079701 | FBpp0071262 | Dpy-30-like 1 (Dpy-30L1) encodes a protein that is part of the COMPASS complex, a histone H3K4 methyltransferase complex thought to be responsible for the bulk of the histone H3K4 di- and trimethylation. The product of Dpy-30L1 binds to, and thereby inhibits, the metal-responsive transcription factor encoded by MTF-1. | CXXC-type zinc finger protein 1; Component of the SET1 complex that specifically di- and trimethylates 'Lys-4' of histone H3. Essential for Set1 association with chromatin and trimethylation of histone H3 at 'Lys-4' at transcription puffs. Additionally, is critical for general chromosomal association of Set1. | 0.974 |
Dpy-30L1 | Dpy-30L2 | FBpp0079701 | FBpp0073137 | Dpy-30-like 1 (Dpy-30L1) encodes a protein that is part of the COMPASS complex, a histone H3K4 methyltransferase complex thought to be responsible for the bulk of the histone H3K4 di- and trimethylation. The product of Dpy-30L1 binds to, and thereby inhibits, the metal-responsive transcription factor encoded by MTF-1. | Dpy-30-like 2 (Dpy-30L2) is expressed in elongated spermatids but not in early or mature sperm. Targeted disruption of the gene results in sperm motility impairment and male sterility. | 0.581 |
Dpy-30L1 | Hcf | FBpp0079701 | FBpp0311451 | Dpy-30-like 1 (Dpy-30L1) encodes a protein that is part of the COMPASS complex, a histone H3K4 methyltransferase complex thought to be responsible for the bulk of the histone H3K4 di- and trimethylation. The product of Dpy-30L1 binds to, and thereby inhibits, the metal-responsive transcription factor encoded by MTF-1. | HCF C-terminal chain; May be involved in control of the cell cycle. | 0.963 |
Dpy-30L1 | Rbbp5 | FBpp0079701 | FBpp0077900 | Dpy-30-like 1 (Dpy-30L1) encodes a protein that is part of the COMPASS complex, a histone H3K4 methyltransferase complex thought to be responsible for the bulk of the histone H3K4 di- and trimethylation. The product of Dpy-30L1 binds to, and thereby inhibits, the metal-responsive transcription factor encoded by MTF-1. | Retinoblastoma-binding protein 5 homolog; Component of the SET1 complex that specifically di- and trimethylates 'Lys-4' of histone H3 and of the MLL3/4 complex which also methylates histone H3 'Lys-4'. | 0.999 |
Dpy-30L1 | Set1 | FBpp0079701 | FBpp0112593 | Dpy-30-like 1 (Dpy-30L1) encodes a protein that is part of the COMPASS complex, a histone H3K4 methyltransferase complex thought to be responsible for the bulk of the histone H3K4 di- and trimethylation. The product of Dpy-30L1 binds to, and thereby inhibits, the metal-responsive transcription factor encoded by MTF-1. | Histone-lysine N-methyltransferase SETD1; Catalytic component of the SET1 complex that specifically di- and trimethylates 'Lys-4' of histone H3 and is the main di- and trimethyltransferase throughout development. Set1-dependent trimethylation regulates chromatin changes at active promoters that ensure optimal RNA polymerase II release into productive elongation, thereby contributing to optimal transcription. | 0.996 |
Dpy-30L1 | Wdr82 | FBpp0079701 | FBpp0079266 | Dpy-30-like 1 (Dpy-30L1) encodes a protein that is part of the COMPASS complex, a histone H3K4 methyltransferase complex thought to be responsible for the bulk of the histone H3K4 di- and trimethylation. The product of Dpy-30L1 binds to, and thereby inhibits, the metal-responsive transcription factor encoded by MTF-1. | WD repeat domain 82 (Wdr82) encodes a component of the Compass complex, which performs K4 methylation of the histone encoded by His3. | 0.977 |
Dpy-30L1 | ash2 | FBpp0079701 | FBpp0084040 | Dpy-30-like 1 (Dpy-30L1) encodes a protein that is part of the COMPASS complex, a histone H3K4 methyltransferase complex thought to be responsible for the bulk of the histone H3K4 di- and trimethylation. The product of Dpy-30L1 binds to, and thereby inhibits, the metal-responsive transcription factor encoded by MTF-1. | Set1/Ash2 histone methyltransferase complex subunit ASH2; Transcriptional regulator. Regulates a number of genes involved in wing development including activation of net and bs and repression of rho and kni and controls vein-intervein patterning during wing development. Required for correct expression of a number of homeotic genes including Scr in the first leg imaginal disk and Ubx in the third leg imaginal disk and haltere disks. Required for stabilization of the histone-lysine N-methyltransferase trr and for trimethylation of 'Lys-4' of histone H3. Plays a role in maintenance of tra [...] | 0.998 |
Dpy-30L1 | wds | FBpp0079701 | FBpp0300790 | Dpy-30-like 1 (Dpy-30L1) encodes a protein that is part of the COMPASS complex, a histone H3K4 methyltransferase complex thought to be responsible for the bulk of the histone H3K4 di- and trimethylation. The product of Dpy-30L1 binds to, and thereby inhibits, the metal-responsive transcription factor encoded by MTF-1. | Protein will die slowly; Contributes to histone modification. May position the N- terminus of histone H3 for efficient trimethylation at 'Lys-4'. | 0.987 |
Dpy-30L2 | Cfp1 | FBpp0073137 | FBpp0071262 | Dpy-30-like 2 (Dpy-30L2) is expressed in elongated spermatids but not in early or mature sperm. Targeted disruption of the gene results in sperm motility impairment and male sterility. | CXXC-type zinc finger protein 1; Component of the SET1 complex that specifically di- and trimethylates 'Lys-4' of histone H3. Essential for Set1 association with chromatin and trimethylation of histone H3 at 'Lys-4' at transcription puffs. Additionally, is critical for general chromosomal association of Set1. | 0.881 |
Dpy-30L2 | Dpy-30L1 | FBpp0073137 | FBpp0079701 | Dpy-30-like 2 (Dpy-30L2) is expressed in elongated spermatids but not in early or mature sperm. Targeted disruption of the gene results in sperm motility impairment and male sterility. | Dpy-30-like 1 (Dpy-30L1) encodes a protein that is part of the COMPASS complex, a histone H3K4 methyltransferase complex thought to be responsible for the bulk of the histone H3K4 di- and trimethylation. The product of Dpy-30L1 binds to, and thereby inhibits, the metal-responsive transcription factor encoded by MTF-1. | 0.581 |
Dpy-30L2 | Hcf | FBpp0073137 | FBpp0311451 | Dpy-30-like 2 (Dpy-30L2) is expressed in elongated spermatids but not in early or mature sperm. Targeted disruption of the gene results in sperm motility impairment and male sterility. | HCF C-terminal chain; May be involved in control of the cell cycle. | 0.734 |
Dpy-30L2 | Rbbp5 | FBpp0073137 | FBpp0077900 | Dpy-30-like 2 (Dpy-30L2) is expressed in elongated spermatids but not in early or mature sperm. Targeted disruption of the gene results in sperm motility impairment and male sterility. | Retinoblastoma-binding protein 5 homolog; Component of the SET1 complex that specifically di- and trimethylates 'Lys-4' of histone H3 and of the MLL3/4 complex which also methylates histone H3 'Lys-4'. | 0.967 |