STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
stacProtein unc-13 homolog 4B; Essential for tracheal development in embryos. Functions with the GTPase Rab39 and downstream of dnd, to regulate lumen fusion between previously separate tracheal branches (anastomosis). Essential component of secretory lysosome-related organelles (SLs) that are present in the tracheal fusion tip cells (FCs). Mediates intracellular fusion of the extending tracheal stalk cell lumen in the FCs by recruiting the SNARE complex component Syx1A to the SLs, this may then enable the SLs to interact with complementary SNAREs (such as Syb) present in the apical membra [...] (1153 aa)    
Predicted Functional Partners:
Stacl
Stac-like, isoform J; It is involved in the biological process described with: skeletal muscle contraction; intracellular signal transduction; positive regulation of cell size; positive regulation of voltage-gated calcium channel activity; positive regulation of protein localization to plasma membrane.
      
 0.911
Ca-alpha1D
Voltage-dependent calcium channel type D subunit alpha-1; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. Encodes a dihydropyridine- and diltiazem- sensitive current in larval body wall muscle. Vital for embryonic development; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family.
      
 0.671
Fum4
Fumarase 4; Fumarate hydratase activity. It is involved in the biological process described with: fumarate metabolic process; malate metabolic process; tricarboxylic acid cycle.
      
 0.669
Rab27
EG:80H7.4 protein; Rab27 (Rab27) encodes a Rab GTPase involved in exosomal secretion.
    
 
 0.622
dnd
Dead end (dnd) encodes an Arf-like3 GTPase that controls the targeting of exocytosis machinery to specific apical domains in fusion cells during the tracheal branch fusion process.
    
 
 0.614
CG8405
LD33689p; It is involved in the biological process described with: wing disc dorsal/ventral pattern formation; response to endoplasmic reticulum stress; positive regulation of ERAD pathway.
      
 0.610
CG15529
RH14395p.
      
 0.607
DIP-iota
Dpr-interacting protein iota; It is involved in the biological process described with: synapse organization.
      
 0.602
Atet
ABC transporter expressed in trachea (Atet) encodes a protein that is involved in transmembrane transport.
      
 0.600
CG43367
Uncharacterized protein, isoform C.
   
  
 0.556
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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