STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CG8270Mic1 domain-containing protein; It is involved in the biological process described with: regulation of autophagy. (642 aa)    
Predicted Functional Partners:
Ccz1
Caffeine, calcium, zinc sensitivity 1 (Ccz1) encodes a protein that forms a complex with the product of Mon1 and acts as an exchange factor of the small G-protein encoded by Rab7. The Ccz1/Mon1 complex activates and recruits the product of Rab7 to the maturing endosome, where it organizes the fusion of the matured endosome with the lysosome. Ccz1/Mon1 complex loss of function results in Rab7 phenotypes.
   
 0.991
Mon1
Monensin sensitivity 1 (Mon1) encodes a protein that forms a complex with the product of Ccz1 and acts as an exchange factor of the small G-protein encoded by Rab7. It activates and recruits the product of Rab7 to the maturing endosome, inducing the fusion of the matured endosome with the lysosome. Mon1/Ccz1 complex loss of function results in Rab7 phenotypes.
   
 0.904
CG9986
LD27564p.
   
  
 0.688
CG13175
GEO13458p1.
   
  
 0.673
CG30159
GH17623p.
    
 
 0.671
CG4467
Uncharacterized protein, isoform B; Metalloaminopeptidase activity; zinc ion binding; peptide binding. It is involved in the biological process described with: peptide catabolic process; proteolysis.
      
 0.669
CG5521
Probable Rho GTPase-activating protein CG5521; GTPase activator activity. It is involved in the biological process described with: regulation of small GTPase mediated signal transduction; positive regulation of GTPase activity.
   
  
 0.668
CG6607
AT25567p; Rab GTPase binding. It is involved in the biological process described with: Rab protein signal transduction.
      
 0.659
Tsp42Ea
Tetraspanin.
    
 
 0.655
CG4041
LD42868p; Rab GTPase binding; GTPase activator activity; ATP binding. It is involved in the biological process described with: activation of GTPase activity; Golgi organization; protein phosphorylation; regulation of GTPase activity; intracellular protein transport.
   
  
 0.631
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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