STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
OliOlig family, isoform A; Protein dimerization activity. It is involved in the biological process described with: motor neuron axon guidance; regulation of transcription, DNA-templated. (232 aa)    
Predicted Functional Partners:
HGTX
GTX/Nkx6B-like homeodomain protein; HGTX (HGTX) encodes a homeodomain transcription factor that acts in parallel with the product of exex to promote the development and differentiation of motor neurons that innervate ventral body wall muscles. Its major roles include neuronal specification and differentiation.
   
  
 0.712
Gart
Trifunctional purine biosynthetic protein adenosine-3; GART trifunctional enzyme (Gart) encodes a multifunctional enzyme that exhibits phosphoribosylamine-glycine ligase, phosphoribosylformylglycinamidine cyclo-ligase and phosphoribosylglycinamide formyltransferase activities; In the N-terminal section; belongs to the GARS family. In the C-terminal section; belongs to the GART family.
   
  
 0.645
vnd
Homeobox protein vnd; Ventral nervous system defective (vnd) encodes a Nk2-class homeodomain transcription factor that acts in a context-dependent manner as an activator or repressor. It has roles in neuroectoderm patterning, formation and specification of ventral neuroblasts and proper development of their cell lineages.
   
 
 0.644
Sox100B
Sox100B (Sox100B) encodes a group E Sox domain transcription factor. It has a role in the development of somatic components of the testis during metamorphosis, where it regulates pigment cell specification. Sox100B shows sexually dimorphic expression in the embryonic gonad.
   
 
 0.574
Fer1
48 related 1 (Fer1) encodes a basic helix loop helix (bHLH) transcription factor. It is mainly expressed in mature neurons and maintains neuronal identity, likely downstream of the product of N.
   
 
 0.570
CG10565
LD23875p; DNA binding.
      
 0.520
sc
Achaete-scute complex protein T4; AS-C proteins are involved in the determination of the neuronal precursors in the peripheral nervous system and the central nervous system. Also involved in sex determination and dosage compensation.
   
 
 0.510
Lim3
Lim3, isoform G; Lim3 (Lim3) encodes a transcription factor that regulates neuronal sub-type identity, including motor neuron identity.
   
  
 0.498
ac
Achaete-scute complex protein T5; Achaete (ac) encodes a BHLH transcription factor that interacts antagonistically with the Notch signaling pathway to promote neural precursor formation. Its major role is in nervous system development.
   
 
 0.486
meigo
Solute carrier family 35 member B1 homolog; Medial glomeruli (meigo) encodes an evolutionarily conserved, multi-membrane pass protein that is mainly localized at the endoplasmic reticulum. meigo genetically interacts with Ephrin in dendrite targeting of olfactory projection neurons.
      
 0.443
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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