STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
OliOlig family, isoform A; Sequence-specific DNA binding transcription factor activity; protein dimerization activity. It is involved in the biological process described with: motor neuron axon guidance; regulation of transcription, DNA-templated (232 aa)    
Predicted Functional Partners:
exex
Extra-extra (Exex) is a homeodomain transcription factor that is expressed in and regulates the differentiation of motor neurons that project axons to ventral body wall muscles. Within the central nervous system, Exex negatively interacts with Lim3 and eve to govern neuronal specification and differentiation. Exex roles include neuronal specification and differentiation
    
 
 0.757
da
Daughterless is a class I bHLH protein important for sex determination and dosage compensation by controlling the feminizing switch gene Sxl. It participates in transcriptional regulation of a wide variety processes, including oogenesis, neurogenesis, myogenesis and cell proliferation
   
 
 0.733
CG13287
Uncharacterized protein, isoform A; Metal ion binding; nucleic acid binding
   
 
 0.696
jumu
Jumeau is a multi-functional transcription factor and acts upstream of a Polo-kinase dependent pathway in one report. Its roles include asymmetric protein localization, chromatin modification, dendrite formation and organ (eye, wing and bristle) development
   
  
 0.609
HGTX
GTX/Nkx6B-like homeodomain protein; HGTX is a homeodomain transcription factor that acts in parallel with exex to promote the development and differentiation of motor neurons that innervate ventral body wall muscles. Its major roles include neuronal specification and differentiation
    
 
 0.577
CG5554
CG5554, isoform A; Protein disulfide isomerase activity. It is involved in the biological process described with: cell redox homeostasis
      
 0.519
Fer1
48 related 1, isoform A; Sequence-specific DNA binding transcription factor activity; protein dimerization activity. It is involved in the biological process described with: regulation of transcription, DNA-templated
   
 
 0.501
CG10565
Uncharacterized protein, isoform A; DNA binding; unfolded protein binding; chromatin binding. It is involved in the biological process described with: protein folding
      
 0.483
toy
Twin of eyeless, isoform A; Sequence-specific DNA binding transcription factor activity; sequence-specific DNA binding; RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity. It is involved in the biological process described with: positive regulation of transcription from RNA polymerase II promoter; brain morphogenesis; ocellus development; compound eye development; positive regulation of gene expression; eye-antennal disc development; regulation of transcription, DNA-templated; mushroom body development
   
 
 0.472
Aats-trp
Tryptophanyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family
      
 0.453
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Drosophila melanogaster, fruit fly
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