STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Ranbp16Ran-binding protein 16; May function as a nuclear transport receptor. (1110 aa)    
Predicted Functional Partners:
RanBP3
Ran binding protein 3 (RanBP3) encodes a chromosome region maintenance 1 (CRM1) cofactor involved in the export of proteins from the nucleus. It negatively regulates Wnt signalling.
    
 
 0.780
msk
D-Importin 7/RanBP7; Moleskin (msk) encodes an importin that contributes to protein import into the nucleus. It is involved in eye development, muscle attachment and wing cell fate specification.
   
  
 0.736
Arts
Artemis, isoform B; Nuclear localization sequence binding; Ran GTPase binding; nuclear import signal receptor activity. It is involved in the biological process described with: protein import into nucleus.
      
 0.713
emb
Exportin-1; Receptor for the leucine-rich nuclear export signal (NES). Binds cooperatively to the NES on its target protein and to the small GTPase Ran in its active GTP-bound form. Involved in the export of dl, RpS2 and the pre-40S ribosome from the nucleus to the cytoplasm. Plays an important role in nuclear pore assembly by mediating nucleoporin condensation and biogenesis of annulate lamellae. Required for the function or maintenance of certain tissues such as brain and gut.
   
 
 0.706
cdm
Cadmus, isoform A; Cadmus (cdm) encodes a member of the importin beta family of nucleocytoplasmic cargo shuttling proteins. It functions at the neuromuscular junction to maintain normal subsynaptic reticulum structure and presynaptic probability of release.
   
  
 0.680
Apl
Apollo, isoform A; Ran GTPase binding; nuclear localization sequence binding; nuclear import signal receptor activity. It is involved in the biological process described with: protein import into nucleus.
      
 0.657
Cse1
Exportin-2; Export receptor for importin alpha. Mediates importin-alpha re-export from the nucleus to the cytoplasm after import substrates have been released into the nucleoplasm (By similarity).
      
 0.625
CG31495
RE10813p; ATPase activity; ATP binding. It is involved in the biological process described with: intra-Golgi vesicle-mediated transport; Golgi vesicle docking; Golgi to plasma membrane protein transport; SNARE complex disassembly.
      
 0.613
ebo
Ellipsoid body open (ebo) encodes a protein that complexes with actin, the product of chic, and Ran-GTPase to mediate actin nuclear export. Loss of ebo during development results in defects in the ellipsoid body of the central complex. In the adult brain, accumulation of nuclear actin results in the inhibition of the product of bs and subsequent loss of visual orientation memory.
   
 
 0.606
CG40228
Transcription elongation factor 1 homolog; Transcription elongation factor implicated in the maintenance of proper chromatin structure in actively transcribed regions. Belongs to the ELOF1 family.
      
 0.601
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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