STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
paraSodium channel protein para; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. Belongs to the sodium channel (TC 1.A.1.10) family. Para subfamily. (2145 aa)    
Predicted Functional Partners:
unc79
Uncoordinated 79 (unc79) encodes a protein involved in circadian locomotor rhythms.
   
 
 0.912
tipE
Protein tipE; Enhances para sodium channel function. Required during pupal development to rescue adult paralysis and also protects adult flies against heat-induced lethality.
   
 
 0.872
Ca-alpha1T
Ca[2+]-channel protein alpha[[1]] subunit T (Ca-alpha1T) encodes an alpha 1 subunit of a T-type like voltage gated calcium channel. It mediates a low voltage activated transient calcium current in antennal lobe projection neurons and wing motoneurons that is sensitive to amiloride.
   
0.853
Teh3
TipE-like protein 3; tipE homolog 3 (Teh3) encodes a protein involved in regulation of sodium transport.
   
  
 0.744
Hk
Hyperkinetic, isoform M; Hyperkinetic (Hk) encodes a beta-subunit of Sh K[+] channels and modulates its channel function. It is important in regulating action potentials in neurons and muscles, and transmitter release.
   
 
 0.743
Mid1
Mid1, isoform A; Stretch-activated, cation-selective, calcium channel activity. It is involved in the biological process described with: calcium ion import across plasma membrane; social behavior; locomotor rhythm.
   
 
 0.697
Ca-beta
Ca2+-channel-protein-beta-subunit, isoform L; Voltage-gated calcium channel activity; high voltage-gated calcium channel activity.
   
 
 0.696
Sh
Potassium voltage-gated channel protein Shaker; Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane. Forms rapidly inactivating tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient and may contribute to A- type currents. Plays a role in the regulation of sleep need or efficiency ; Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) s [...]
   
 
 0.675
Oseg4
Outer segment 4, isoform A; It is involved in the biological process described with: intraciliary retrograde transport; cilium assembly; positive regulation of canonical Wnt signaling pathway; non-motile cilium assembly.
    
 
 0.665
Teh1
TipE homolog 1, isoform B; tipE homolog 1 (Teh1) encodes a protein involved in regulation of sodium transport.
   
  
 0.662
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
Server load: low (22%) [HD]