STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
mvMauve; It is involved in the biological process described with: phagocytosis; negative regulation of autophagic vacuole size; lysosomal transport; lysosome organization (3535 aa)    
Predicted Functional Partners:
Atg8a
Autophagy-related 8a (Atg8a) is a ubiquitin-like protein that is conjugated to phosphatidylethanolamine, and this lipid modification anchors it into the membrane of forming and completed autophagosomes. Atg8a roles include autophagosome formation, maintaining neuromuscular function and normal lifespan
   
 
 0.768
CG12288
Uncharacterized protein; mRNA binding; poly(A) binding; nucleotide binding
   
  
 0.744
unc-13-4A
Unc-13-4A, isoform B; It is involved in the biological process described with: synaptic vesicle priming; neurotransmitter secretion
   
  
 0.730
CG7967
Vesicle trafficking 1; ATPase activator activity. It is involved in the biological process described with: endosome transport via multivesicular body sorting pathway
    
 
 0.725
Npl4
Nuclear protein localization protein 4 homolog; May be part of a complex that binds ubiquitinated proteins and that is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome; Belongs to the NPL4 family
      
 0.698
Nopp140
Nopp140, isoform E; Nopp140 is a nucleolar and Cajal body protein. It is predicted to function as a chaperone in the assembly of small nucleolar ribonucleoprotein particles within Cajal bodies, their transit to nucleoli, and their association with pre-ribosomal RNA within nucleolar dense fibrillar regions
      
 0.693
lt
Light, isoform A; Zinc ion binding
   
  
 0.686
VhaAC39-1
V-type proton ATPase subunit d 1; Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation (By similarity)
      
 0.657
Atg8b
Autophagy-related 8b, isoform A; Protein tag. It is involved in the biological process described with: macroautophagy; Belongs to the ATG8 family
   
 
 0.656
Blos1
Biogenesis of lysosome-related organelles complex 1, subunit 1 is a subunit of the octameric complex BLOC-1. BLOC-1 is a cytosolic factor involved in membrane traffic that controls eye color, synaptic morphology, homeostatic synaptic plasticity, and synaptic vesicle recycling
      
 0.654
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Drosophila melanogaster, fruit fly
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