STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
FASN3Fatty acid synthase 3; Oxidoreductase activity; phosphopantetheine binding; fatty acid synthase activity; hydrolase activity, acting on ester bonds. It is involved in the biological process described with: biosynthetic process. (2394 aa)    
Predicted Functional Partners:
beg
Probable malonyl-CoA-acyl carrier protein transacylase, mitochondrial; Catalyzes the transfer of a malonyl moiety from malonyl-CoA to the free thiol group of the phosphopantetheine arm of the ACP protein. This suggests the existence of the biosynthesis of fatty acids in mitochondria (By similarity).
  
 0.963
ACC
Acetyl-CoA carboxylase (ACC) encodes a ubiquitous metabolic enzyme. It catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting substrate for fatty acid synthesis. It is essential in the embryo and in the oenocytes (specialized abdominal cells) for the watertightness of the respiratory system. It is required in the fat body for triglyceride storage and in the muscles for locomotor activity.
  
 
 0.952
ATPCL
ATP-citrate synthase; ATP citrate lyase (ATPCL) encodes a protein involved in glucose homeostasis; In the C-terminal section; belongs to the succinate/malate CoA ligase alpha subunit family.
   
 0.952
CG12170
3-oxoacyl-[acyl-carrier-protein] synthase activity. It is involved in the biological process described with: fatty acid biosynthetic process; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.
  
 
0.935
CG16935
Enoyl-[acyl-carrier-protein] reductase, mitochondrial; Catalyzes the NADPH-dependent reduction of trans-2-enoyl thioesters in mitochondrial fatty acid synthesis (fatty acid synthesis type II). Fatty acid chain elongation in mitochondria uses acyl carrier protein (ACP) as an acyl group carrier, but the enzyme accepts both ACP and CoA thioesters as substrates in vitro. Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.
  
 0.932
FASN2
Fatty acid synthase 2 (FASN2) encodes an enzyme required for the synthesis of branched/methylated long chain fatty acids that are the precursors of methylated cuticular hydrocarbons.
  
 
0.927
CG3961
LD09909p; Long-chain fatty acid-CoA ligase activity. It is involved in the biological process described with: fatty acid biosynthetic process; long-chain fatty acid metabolic process.
   
 0.917
bgm
Very long-chain-fatty-acid--CoA ligase bubblegum; Mediates activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Probably by regulating lipid storage and catabolism, plays a role in neuronal function.
   
 0.917
hll
Long-chain-fatty-acid--CoA ligase heimdall; Mediates activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Probably by regulating lipid storage and catabolism, plays a role in neuronal function ; Belongs to the ATP-dependent AMP-binding enzyme family. Bubblegum subfamily.
   
 0.917
CG3603
RH09070p; Estradiol 17-beta-dehydrogenase activity; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; 3-hydroxyacyl-CoA dehydrogenase activity; quinone binding. It is involved in the biological process described with: oxidation-reduction process; fatty acid biosynthetic process.
   
 0.917
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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