STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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[Homology]
Score
Nlg2Neuroligin 2 (Nlg2) encodes a transmembrane protein that interacts with the product of Nrx-1, and recruits scaffolding proteins for organization of postsynaptic neurotransmitter receptors. The product of Nlg2 functions in synaptic growth and regulation, and is involved in the modulation of social and courtship behavior. (1248 aa)    
Predicted Functional Partners:
Nrx-1
Neurexin 1, isoform F; Neurexin 1 (Nrx-1) encodes a transmembrane synaptic adhesive molecule that regulates the synaptic architecture and function in the brain and neuromuscular junction. It contributes to synaptic growth, transmission, synaptic formation and also regulation of learning and memory, locomotion and visual function.
   
 0.999
CASK
Peripheral plasma membrane protein CASK; CASK (CASK) encodes a member of the MAGUK family of scaffolding proteins. In epithelial tissues, the product of CASK functions as an adhesion molecule involved in cell proliferation, cytoskeletal remodeling and cell migration. In neurons, the product of CASK serves as a scaffold for a number of signaling and transmembrane molecules and is involved in synaptic development and plasticity.
   
 0.756
Liprin-alpha
Liprin-alpha, isoform E; Liprin-alpha (Liprin-alpha) encodes a scaffolding protein that interacts with the receptor phosphatase Lar. It is involved in synapse morphogenesis and axon guidance.
      
 0.709
cin
Molybdenum cofactor synthesis protein cinnamon; Catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step, molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released; In the N-terminal section; belongs to the MoaB/Mog family.
      
 0.696
Nlg1
Neuroligin 1 (Nlg1) encodes a transsynaptic adhesion protein of the neuroligin family that is expressed in muscles and accumulates at the postsynaptic side of neuromuscular junctions. Lack of Nlg1 causes smaller and underdeveloped neuromuscular junctions due to insufficient postsynaptic maturation and differentiation of synaptic boutons; Belongs to the type-B carboxylesterase/lipase family.
  
 
0.661
brp
Bruchpilot, isoform J; Bruchpilot (brp) encodes a cytoskeletal protein critical for structural integrity of electron-dense projection (T-bar) at pre-active zones. It contributes to Ca[2+] channel clustering, size regulation of the synaptic vesicle readily releaseable pool and anesthesia-resistant memory formation.
   
  
 0.659
Ephrin
Ephrin, isoform A; Ephrin (Ephrin) encodes the ligand of the product of Eph. It is involved in nervous system development; Belongs to the ephrin family.
      
 0.628
Prosap
Prosap, isoform A; Prosap (Prosap) encodes a member of SH3 and multiple ankyrin repeat domain (SHANK) family of genes that encode synaptic scaffolding proteins. It regulates synaptic growth and development, including the structure of the neuromuscular junction and synapses of the calyx, and olfactory acuity.
     
 0.625
GluRIIA
Glutamate receptor IIA (GluRIIA) encodes a subunit of the muscle glutamate receptor that responds to neurotransmitter at the neuromuscular junction.
   
  
 0.612
Nlg3
Neuroligin 3, isoform B; Neuroligin 3 (Nlg3) encodes a synaptic adhesion molecule involved in synapse formation and synaptic transmission.
  
 
0.564
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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