STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
barkProtein bark beetle; Required for the maturation but not the establishment of septate junctions in developing epithelial cells and is involved in epithelial cell adhesion during septate junction maturation. Plays a role in the proper localization of the septate junction core components pck/mega, kune, Nrx-IV and Nrg during late embryogenesis. Involved in the formation of tricellular junctions which mediate cell contact where three epithelial cells meet but not of bicellular junctions. Required for the accumulation of Gli at tricellular junctions. (3123 aa)    
Predicted Functional Partners:
CG18507
RE25285p.
  
  
 0.680
CG34189
TIL domain-containing protein; Protein homodimerization activity.
      
 0.652
CG10936
RE29777p.
   
 
 0.644
CG10175
Uncharacterized protein, isoform D; Carboxylic ester hydrolase activity; Belongs to the type-B carboxylesterase/lipase family.
    
 
 0.640
CG31705
BcDNA.GH07269.
    
 
 0.628
CG33093
IP08537p; Dioxygenase activity. It is involved in the biological process described with: oxidation-reduction process; Belongs to the iron/ascorbate-dependent oxidoreductase family.
      
 0.627
CG12239
GH14380p.
      
 0.606
Spt-I
Pyridoxal phosphate binding; serine C-palmitoyltransferase activity. It is involved in the biological process described with: positive regulation of sphingolipid biosynthetic process; ceramide biosynthetic process; sphingosine biosynthetic process.
      
 0.605
Daxx
Daxx-like protein; Transcription regulator. Acts as a histone chaperone that facilitates deposition of histone H3.3. Has a role in chromatin remodeling together with asf1 and XNP. Has role in the transcriptional apoptotic response to oxidative and UV stress.
   
 
 0.569
CG42671
Uncharacterized protein, isoform K.
    
 
 0.560
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.