node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ATPsyngamma | blw | FBpp0084906 | FBpp0071794 | ATP synthase subunit gamma, mitochondrial; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the [...] | ATP synthase subunit alpha, mitochondrial; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the [...] | 0.999 |
ATPsyngamma | lid | FBpp0084906 | FBpp0311492 | ATP synthase subunit gamma, mitochondrial; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the [...] | Lysine-specific demethylase lid; Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Specifically demethylates trimethylated H3 'Lys-4'. Required for the correct regulation of homeotic genes during development. Plays a role in the regulation of the circadian rhythm and in maintaining the normal periodicity of the circadian clock. Regulates the expression of clock-controlled genes including tim, per and cry. | 0.944 |
ATPsyngamma | mt:ATPase6 | FBpp0084906 | FBpp0390630 | ATP synthase subunit gamma, mitochondrial; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the [...] | ATP synthase subunit a; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subuni [...] | 0.999 |
CG14220 | CG15356 | FBpp0297991 | FBpp0077538 | FI07430p; Histone deacetylase activity; histone deacetylase binding. It is involved in the biological process described with: histone deacetylation; negative regulation of transcription by RNA polymerase II. | FI15207p1; It is involved in the biological process described with: regulation of transcription, DNA-templated. | 0.976 |
CG14220 | CG3815 | FBpp0297991 | FBpp0070864 | FI07430p; Histone deacetylase activity; histone deacetylase binding. It is involved in the biological process described with: histone deacetylation; negative regulation of transcription by RNA polymerase II. | GH06635p; Transcription coregulator activity. It is involved in the biological process described with: negative regulation of transcription by RNA polymerase II; regulation of transcription, DNA-templated. | 0.982 |
CG14220 | Caf1-55 | FBpp0297991 | FBpp0082511 | FI07430p; Histone deacetylase activity; histone deacetylase binding. It is involved in the biological process described with: histone deacetylation; negative regulation of transcription by RNA polymerase II. | Probable histone-binding protein Caf1; Core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism. These include the chromatin assembly factor 1 (CAF-1) complex, which is required for chromatin assembly following DNA replication and DNA repair; the nucleosome remodeling and deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylati [...] | 0.992 |
CG14220 | HDAC1 | FBpp0297991 | FBpp0073173 | FI07430p; Histone deacetylase activity; histone deacetylase binding. It is involved in the biological process described with: histone deacetylation; negative regulation of transcription by RNA polymerase II. | Histone deacetylase HDAC1; Catalyzes the deacetylation of lysine residues on the N- terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation may constitute a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. For instance, deacetylation of histone H3 may be a prerequisite for the subsequent recruitment of the histone methyltransferase Su(var)3-9 to histones. Involved in position-effect variegation (PEV). In the larval brain, part of a regulatory network including the transcript [...] | 0.998 |
CG14220 | MRG15 | FBpp0297991 | FBpp0306049 | FI07430p; Histone deacetylase activity; histone deacetylase binding. It is involved in the biological process described with: histone deacetylation; negative regulation of transcription by RNA polymerase II. | NuA4 complex subunit EAF3 homolog; Part of the Tip60 chromatin-remodeling complex which is involved in DNA repair. Upon induction of DNA double-strand breaks, this complex acetylates phosphorylated H2AV in nucleosomes and exchanges it with unmodified H2AV. | 0.849 |
CG14220 | Sin3A | FBpp0297991 | FBpp0293225 | FI07430p; Histone deacetylase activity; histone deacetylase binding. It is involved in the biological process described with: histone deacetylation; negative regulation of transcription by RNA polymerase II. | Sin3A, isoform G; Sin3A (Sin3A) encodes a chromatin regulator with roles during muscle development, cell migration and Wnt signalling regulation. | 0.999 |
CG14220 | lid | FBpp0297991 | FBpp0311492 | FI07430p; Histone deacetylase activity; histone deacetylase binding. It is involved in the biological process described with: histone deacetylation; negative regulation of transcription by RNA polymerase II. | Lysine-specific demethylase lid; Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Specifically demethylates trimethylated H3 'Lys-4'. Required for the correct regulation of homeotic genes during development. Plays a role in the regulation of the circadian rhythm and in maintaining the normal periodicity of the circadian clock. Regulates the expression of clock-controlled genes including tim, per and cry. | 0.947 |
CG15356 | CG14220 | FBpp0077538 | FBpp0297991 | FI15207p1; It is involved in the biological process described with: regulation of transcription, DNA-templated. | FI07430p; Histone deacetylase activity; histone deacetylase binding. It is involved in the biological process described with: histone deacetylation; negative regulation of transcription by RNA polymerase II. | 0.976 |
CG15356 | CG3815 | FBpp0077538 | FBpp0070864 | FI15207p1; It is involved in the biological process described with: regulation of transcription, DNA-templated. | GH06635p; Transcription coregulator activity. It is involved in the biological process described with: negative regulation of transcription by RNA polymerase II; regulation of transcription, DNA-templated. | 0.987 |
CG15356 | Caf1-55 | FBpp0077538 | FBpp0082511 | FI15207p1; It is involved in the biological process described with: regulation of transcription, DNA-templated. | Probable histone-binding protein Caf1; Core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism. These include the chromatin assembly factor 1 (CAF-1) complex, which is required for chromatin assembly following DNA replication and DNA repair; the nucleosome remodeling and deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylati [...] | 0.950 |
CG15356 | HDAC1 | FBpp0077538 | FBpp0073173 | FI15207p1; It is involved in the biological process described with: regulation of transcription, DNA-templated. | Histone deacetylase HDAC1; Catalyzes the deacetylation of lysine residues on the N- terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation may constitute a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. For instance, deacetylation of histone H3 may be a prerequisite for the subsequent recruitment of the histone methyltransferase Su(var)3-9 to histones. Involved in position-effect variegation (PEV). In the larval brain, part of a regulatory network including the transcript [...] | 0.977 |
CG15356 | MRG15 | FBpp0077538 | FBpp0306049 | FI15207p1; It is involved in the biological process described with: regulation of transcription, DNA-templated. | NuA4 complex subunit EAF3 homolog; Part of the Tip60 chromatin-remodeling complex which is involved in DNA repair. Upon induction of DNA double-strand breaks, this complex acetylates phosphorylated H2AV in nucleosomes and exchanges it with unmodified H2AV. | 0.910 |
CG15356 | Sin3A | FBpp0077538 | FBpp0293225 | FI15207p1; It is involved in the biological process described with: regulation of transcription, DNA-templated. | Sin3A, isoform G; Sin3A (Sin3A) encodes a chromatin regulator with roles during muscle development, cell migration and Wnt signalling regulation. | 0.991 |
CG15356 | lid | FBpp0077538 | FBpp0311492 | FI15207p1; It is involved in the biological process described with: regulation of transcription, DNA-templated. | Lysine-specific demethylase lid; Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Specifically demethylates trimethylated H3 'Lys-4'. Required for the correct regulation of homeotic genes during development. Plays a role in the regulation of the circadian rhythm and in maintaining the normal periodicity of the circadian clock. Regulates the expression of clock-controlled genes including tim, per and cry. | 0.995 |
CG3815 | CG14220 | FBpp0070864 | FBpp0297991 | GH06635p; Transcription coregulator activity. It is involved in the biological process described with: negative regulation of transcription by RNA polymerase II; regulation of transcription, DNA-templated. | FI07430p; Histone deacetylase activity; histone deacetylase binding. It is involved in the biological process described with: histone deacetylation; negative regulation of transcription by RNA polymerase II. | 0.982 |
CG3815 | CG15356 | FBpp0070864 | FBpp0077538 | GH06635p; Transcription coregulator activity. It is involved in the biological process described with: negative regulation of transcription by RNA polymerase II; regulation of transcription, DNA-templated. | FI15207p1; It is involved in the biological process described with: regulation of transcription, DNA-templated. | 0.987 |
CG3815 | Caf1-55 | FBpp0070864 | FBpp0082511 | GH06635p; Transcription coregulator activity. It is involved in the biological process described with: negative regulation of transcription by RNA polymerase II; regulation of transcription, DNA-templated. | Probable histone-binding protein Caf1; Core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism. These include the chromatin assembly factor 1 (CAF-1) complex, which is required for chromatin assembly following DNA replication and DNA repair; the nucleosome remodeling and deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylati [...] | 0.996 |