STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurrence
Coexpression
Experiments
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[Homology]
Score
uifUninflatable, isoform C; Uninflatable (uif) encodes a single pass transmembrane protein that localizes to the apical plasma membrane in epithelial cells. It is required for embryonic tracheal maturation and tracheal growth in the larva. (3589 aa)    
Predicted Functional Partners:
serp
Serpentine, isoform B; Serpentine (serp) encodes a putative chitin deacetylase. It is expressed by the epidermal and tracheal cells and is secreted into the apical extracellular space. Its activity maintains the strength of cuticles and restricts tracheal tube length.
  
  
 0.858
verm
Vermiform, isoform I; Vermiform (verm) encodes a chitin deacetylase-like protein that is secreted by tracheal cells and accumulates in the embryonic tracheal lumen. Its functions include cuticle development and tracheal tube size control.
  
  
 0.854
Gasp
Gasp, isoform A; Gasp (Gasp) encodes a protein involved in cuticle biosynthesis during embryonic tracheal system development.
  
 
 0.775
reb
FI01543p; Rebuf (reb) and the related exp encode proteins that belong to the Smad/FHA superfamily and have interchangeable functions. Both are required for the process of chitin deposition, together with the chitin synthase encoded by kkv.
  
  
 0.705
CG9717
RE02508p; Sulfate transmembrane transporter activity; anion:anion antiporter activity; secondary active sulfate transmembrane transporter activity. It is involved in the biological process described with: sulfate transport; transmembrane transport.
      
 0.660
kune
Kune-kune; It is involved in the biological process described with: establishment of glial blood-brain barrier; regulation of tube length, open tracheal system; septate junction assembly.
    
 
 0.644
exp
Expansion, isoform A; Expansion (exp) encodes an atypical Smad-like protein which regulates tube size in the trachea through receptor tyrosine kinase (RTK) pathways, as well as apical secretion pathways.
  
  
 0.644
CG4496
FI17813p1; RNA polymerase II regulatory region sequence-specific DNA binding; sequence-specific DNA binding; zinc ion binding; DNA-binding transcription factor activity, RNA polymerase II-specific. It is involved in the biological process described with: regulation of transcription by RNA polymerase II.
    
 
 0.633
obst-A
Obstructor-A, isoform A; obstructor-A (obst-A) encodes a protein that forms a core complex with chitin and the chitin modifying proteins encoded by serp and knk. This complex is required for assembly, maturation and preservation of the chitinous cuticles at the end of embryogenesis and probably throughout larval development.
  
 
 0.608
Pgant8
Polypeptide N-acetylgalactosaminyltransferase 8; Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. It can both act as a peptide transferase that transfers GalNAc onto unmodified peptide substrates, and as a glycopeptide transferase that requires the prior addition of a GalNAc on a peptide before adding additional GalNAc moieties. Prefers both EA2 and the diglycosylated Muc5AC-3/13 as substrates, albeit at very low levels fro Muc5AC-3/13. Belongs to the gl [...]
      
 0.604
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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