node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Ada | Adar | FBpp0081451 | FBpp0308381 | Adenosine deaminase-like protein; Catalyzes the hydrolysis of the free cytosolic methylated adenosine nucleotide N(6)-methyl-AMP (N6-mAMP) to produce inositol monophosphate (IMP) and methylamine. Is required for the catabolism of cytosolic N6-mAMP, which is derived from the degradation of mRNA containing N6-methylated adenine (m6A); Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. | Double-stranded RNA-specific editase Adar; Has A-to-I RNA editing activity on extended dsRNA: edits RNA- binding protein Rnp4F. A-to-I editing of pre-mRNAs acts predominantly through nervous system targets to affect adult nervous system integrity, function and behavior. Essential for adaptation to environmental stresses, such as oxygen deprivation, and for the prevention of premature neuronal degeneration, through the editing of ion channels as targets. | 0.975 |
Ada | Dcr-2 | FBpp0081451 | FBpp0086061 | Adenosine deaminase-like protein; Catalyzes the hydrolysis of the free cytosolic methylated adenosine nucleotide N(6)-methyl-AMP (N6-mAMP) to produce inositol monophosphate (IMP) and methylamine. Is required for the catabolism of cytosolic N6-mAMP, which is derived from the degradation of mRNA containing N6-methylated adenine (m6A); Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. | Dicer-2, isoform A; Dicer-2 (Dcr-2) encodes a member of the RNase III family of double-stranded RNA-specific endonucleases. It acts in the RNAi pathway by cutting long dsRNA into siRNAs. It helps defend flies against viral infection, particularly RNA viruses. It also processes long, partially double-stranded endogenous transcripts (hairpin RNAs) into endo-siRNAs. | 0.775 |
Ada | Tudor-SN | FBpp0081451 | FBpp0304417 | Adenosine deaminase-like protein; Catalyzes the hydrolysis of the free cytosolic methylated adenosine nucleotide N(6)-methyl-AMP (N6-mAMP) to produce inositol monophosphate (IMP) and methylamine. Is required for the catabolism of cytosolic N6-mAMP, which is derived from the degradation of mRNA containing N6-methylated adenine (m6A); Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. | Staphylococcal nuclease domain-containing protein 1; Endonuclease which shows activity towards both DNA and RNA substrates. Has a role in translation regulation throught its association with the with the RNA- induced silencing complex (RISC). Plays a role in spermatogenesis probably by negatively regulating piwi expression in the germline. Together with piwi, might be involved in transposon repression in the germline. | 0.400 |
Ada | drosha | FBpp0081451 | FBpp0087926 | Adenosine deaminase-like protein; Catalyzes the hydrolysis of the free cytosolic methylated adenosine nucleotide N(6)-methyl-AMP (N6-mAMP) to produce inositol monophosphate (IMP) and methylamine. Is required for the catabolism of cytosolic N6-mAMP, which is derived from the degradation of mRNA containing N6-methylated adenine (m6A); Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. | Ribonuclease; Drosha (drosha) encodes a protein that contributes to miRNA processing. It is involved in salivary gland histolysis and oocyte development. | 0.614 |
Ada | mbl | FBpp0081451 | FBpp0307871 | Adenosine deaminase-like protein; Catalyzes the hydrolysis of the free cytosolic methylated adenosine nucleotide N(6)-methyl-AMP (N6-mAMP) to produce inositol monophosphate (IMP) and methylamine. Is required for the catabolism of cytosolic N6-mAMP, which is derived from the degradation of mRNA containing N6-methylated adenine (m6A); Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. | Muscleblind (mbl) encodes an RNA binding protein that regulates RNA metabolism at the levels of alternative splicing, transcript localization and miRNA and circRNA biogenesis. It contributes to terminal muscle, eye and neural differentiation. | 0.674 |
Adar | Ada | FBpp0308381 | FBpp0081451 | Double-stranded RNA-specific editase Adar; Has A-to-I RNA editing activity on extended dsRNA: edits RNA- binding protein Rnp4F. A-to-I editing of pre-mRNAs acts predominantly through nervous system targets to affect adult nervous system integrity, function and behavior. Essential for adaptation to environmental stresses, such as oxygen deprivation, and for the prevention of premature neuronal degeneration, through the editing of ion channels as targets. | Adenosine deaminase-like protein; Catalyzes the hydrolysis of the free cytosolic methylated adenosine nucleotide N(6)-methyl-AMP (N6-mAMP) to produce inositol monophosphate (IMP) and methylamine. Is required for the catabolism of cytosolic N6-mAMP, which is derived from the degradation of mRNA containing N6-methylated adenine (m6A); Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. | 0.975 |
Adar | Adgf-B | FBpp0308381 | FBpp0074957 | Double-stranded RNA-specific editase Adar; Has A-to-I RNA editing activity on extended dsRNA: edits RNA- binding protein Rnp4F. A-to-I editing of pre-mRNAs acts predominantly through nervous system targets to affect adult nervous system integrity, function and behavior. Essential for adaptation to environmental stresses, such as oxygen deprivation, and for the prevention of premature neuronal degeneration, through the editing of ion channels as targets. | Adenosine deaminase-related growth factor B; Adenosine deaminase activity. It is involved in the biological process described with: inosine biosynthetic process; adenosine catabolic process. | 0.975 |
Adar | Adgf-D | FBpp0308381 | FBpp0082310 | Double-stranded RNA-specific editase Adar; Has A-to-I RNA editing activity on extended dsRNA: edits RNA- binding protein Rnp4F. A-to-I editing of pre-mRNAs acts predominantly through nervous system targets to affect adult nervous system integrity, function and behavior. Essential for adaptation to environmental stresses, such as oxygen deprivation, and for the prevention of premature neuronal degeneration, through the editing of ion channels as targets. | Adenosine deaminase-related growth factor D (Adgf-D) encodes an adenosine deaminase involved in cell proliferation. | 0.975 |
Adar | Adgf-E | FBpp0308381 | FBpp0086611 | Double-stranded RNA-specific editase Adar; Has A-to-I RNA editing activity on extended dsRNA: edits RNA- binding protein Rnp4F. A-to-I editing of pre-mRNAs acts predominantly through nervous system targets to affect adult nervous system integrity, function and behavior. Essential for adaptation to environmental stresses, such as oxygen deprivation, and for the prevention of premature neuronal degeneration, through the editing of ion channels as targets. | Adenosine deaminase-related growth factor E; It is involved in the biological process described with: inosine biosynthetic process. | 0.975 |
Adar | Dcr-2 | FBpp0308381 | FBpp0086061 | Double-stranded RNA-specific editase Adar; Has A-to-I RNA editing activity on extended dsRNA: edits RNA- binding protein Rnp4F. A-to-I editing of pre-mRNAs acts predominantly through nervous system targets to affect adult nervous system integrity, function and behavior. Essential for adaptation to environmental stresses, such as oxygen deprivation, and for the prevention of premature neuronal degeneration, through the editing of ion channels as targets. | Dicer-2, isoform A; Dicer-2 (Dcr-2) encodes a member of the RNase III family of double-stranded RNA-specific endonucleases. It acts in the RNAi pathway by cutting long dsRNA into siRNAs. It helps defend flies against viral infection, particularly RNA viruses. It also processes long, partially double-stranded endogenous transcripts (hairpin RNAs) into endo-siRNAs. | 0.705 |
Adar | Fmr1 | FBpp0308381 | FBpp0300445 | Double-stranded RNA-specific editase Adar; Has A-to-I RNA editing activity on extended dsRNA: edits RNA- binding protein Rnp4F. A-to-I editing of pre-mRNAs acts predominantly through nervous system targets to affect adult nervous system integrity, function and behavior. Essential for adaptation to environmental stresses, such as oxygen deprivation, and for the prevention of premature neuronal degeneration, through the editing of ion channels as targets. | Synaptic functional regulator FMR1; Polyribosome-associated RNA-binding protein that plays a role in neuronal development and synaptic plasticity through the regulation of protein synthesis of mRNAs. Plays a role as a negative translational regulator of specific mRNAs. Represses translation of the microtubule-associated protein futsch mRNA to regulate microtubule-dependent synaptic growth and function. May also be involved in microRNA (miRNA)-mediated translational suppression as part of the RNA-induced silencing complex (RISC). Required for stability of the central pair of microtubule [...] | 0.855 |
Adar | Rnp4F | FBpp0308381 | FBpp0070720 | Double-stranded RNA-specific editase Adar; Has A-to-I RNA editing activity on extended dsRNA: edits RNA- binding protein Rnp4F. A-to-I editing of pre-mRNAs acts predominantly through nervous system targets to affect adult nervous system integrity, function and behavior. Essential for adaptation to environmental stresses, such as oxygen deprivation, and for the prevention of premature neuronal degeneration, through the editing of ion channels as targets. | RNA-binding protein 4F (Rnp4F) encodes an essential evolutionarily-conserved RNA-binding protein. Rnp4F gene expression is post-transcriptionally regulated by interaction with a stable stem-loop structure in the 5'-UTR of the mRNA with trans-acting factors. | 0.797 |
Adar | Tudor-SN | FBpp0308381 | FBpp0304417 | Double-stranded RNA-specific editase Adar; Has A-to-I RNA editing activity on extended dsRNA: edits RNA- binding protein Rnp4F. A-to-I editing of pre-mRNAs acts predominantly through nervous system targets to affect adult nervous system integrity, function and behavior. Essential for adaptation to environmental stresses, such as oxygen deprivation, and for the prevention of premature neuronal degeneration, through the editing of ion channels as targets. | Staphylococcal nuclease domain-containing protein 1; Endonuclease which shows activity towards both DNA and RNA substrates. Has a role in translation regulation throught its association with the with the RNA- induced silencing complex (RISC). Plays a role in spermatogenesis probably by negatively regulating piwi expression in the germline. Together with piwi, might be involved in transposon repression in the germline. | 0.680 |
Adar | drosha | FBpp0308381 | FBpp0087926 | Double-stranded RNA-specific editase Adar; Has A-to-I RNA editing activity on extended dsRNA: edits RNA- binding protein Rnp4F. A-to-I editing of pre-mRNAs acts predominantly through nervous system targets to affect adult nervous system integrity, function and behavior. Essential for adaptation to environmental stresses, such as oxygen deprivation, and for the prevention of premature neuronal degeneration, through the editing of ion channels as targets. | Ribonuclease; Drosha (drosha) encodes a protein that contributes to miRNA processing. It is involved in salivary gland histolysis and oocyte development. | 0.755 |
Adar | mbl | FBpp0308381 | FBpp0307871 | Double-stranded RNA-specific editase Adar; Has A-to-I RNA editing activity on extended dsRNA: edits RNA- binding protein Rnp4F. A-to-I editing of pre-mRNAs acts predominantly through nervous system targets to affect adult nervous system integrity, function and behavior. Essential for adaptation to environmental stresses, such as oxygen deprivation, and for the prevention of premature neuronal degeneration, through the editing of ion channels as targets. | Muscleblind (mbl) encodes an RNA binding protein that regulates RNA metabolism at the levels of alternative splicing, transcript localization and miRNA and circRNA biogenesis. It contributes to terminal muscle, eye and neural differentiation. | 0.716 |
Adgf-B | Adar | FBpp0074957 | FBpp0308381 | Adenosine deaminase-related growth factor B; Adenosine deaminase activity. It is involved in the biological process described with: inosine biosynthetic process; adenosine catabolic process. | Double-stranded RNA-specific editase Adar; Has A-to-I RNA editing activity on extended dsRNA: edits RNA- binding protein Rnp4F. A-to-I editing of pre-mRNAs acts predominantly through nervous system targets to affect adult nervous system integrity, function and behavior. Essential for adaptation to environmental stresses, such as oxygen deprivation, and for the prevention of premature neuronal degeneration, through the editing of ion channels as targets. | 0.975 |
Adgf-B | Adgf-E | FBpp0074957 | FBpp0086611 | Adenosine deaminase-related growth factor B; Adenosine deaminase activity. It is involved in the biological process described with: inosine biosynthetic process; adenosine catabolic process. | Adenosine deaminase-related growth factor E; It is involved in the biological process described with: inosine biosynthetic process. | 0.489 |
Adgf-B | Dcr-2 | FBpp0074957 | FBpp0086061 | Adenosine deaminase-related growth factor B; Adenosine deaminase activity. It is involved in the biological process described with: inosine biosynthetic process; adenosine catabolic process. | Dicer-2, isoform A; Dicer-2 (Dcr-2) encodes a member of the RNase III family of double-stranded RNA-specific endonucleases. It acts in the RNAi pathway by cutting long dsRNA into siRNAs. It helps defend flies against viral infection, particularly RNA viruses. It also processes long, partially double-stranded endogenous transcripts (hairpin RNAs) into endo-siRNAs. | 0.775 |
Adgf-B | Tudor-SN | FBpp0074957 | FBpp0304417 | Adenosine deaminase-related growth factor B; Adenosine deaminase activity. It is involved in the biological process described with: inosine biosynthetic process; adenosine catabolic process. | Staphylococcal nuclease domain-containing protein 1; Endonuclease which shows activity towards both DNA and RNA substrates. Has a role in translation regulation throught its association with the with the RNA- induced silencing complex (RISC). Plays a role in spermatogenesis probably by negatively regulating piwi expression in the germline. Together with piwi, might be involved in transposon repression in the germline. | 0.400 |
Adgf-B | drosha | FBpp0074957 | FBpp0087926 | Adenosine deaminase-related growth factor B; Adenosine deaminase activity. It is involved in the biological process described with: inosine biosynthetic process; adenosine catabolic process. | Ribonuclease; Drosha (drosha) encodes a protein that contributes to miRNA processing. It is involved in salivary gland histolysis and oocyte development. | 0.617 |