STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
wdsProtein will die slowly; Contributes to histone modification. May position the N- terminus of histone H3 for efficient trimethylation at 'Lys-4'. (361 aa)    
Predicted Functional Partners:
dgt1
Dim gamma-tubulin 1, isoform C; Histone acetyltransferase activity (H4-K16 specific); histone acetyltransferase activity (H4-K8 specific); histone acetyltransferase activity (H4-K5 specific). It is involved in the biological process described with: histone H4-K16 acetylation; histone H4-K8 acetylation; histone H4-K5 acetylation.
   
 0.999
Rcd5
Reduction in Cnn dots 5 (Rcd5) encodes a protein that belongs to the family of forkhead-associated domain proteins. As part of the non-specific lethal complex, it regulates transcription of housekeeping genes by facilitating recruitment of RNA polymerase II to promoters. During mitosis it plays a key role in chromosomal-dependent microtubule assembly, centriole duplication and pericentriolar material maturation.
   
 0.998
Rcd1
Reduction in Cnn dots 1 (Rcd1) encodes a protein involved in centriole replication and transcription regulation.
   
 0.997
Hcf
HCF C-terminal chain; May be involved in control of the cell cycle.
   
 0.996
MBD-R2
MBD-R2 (MBD-R2) encodes a Zinc finger C2H2 transcription factor. It is a component of nonspecific lethal (NSL) complex involved in transcriptional activation.
    
 0.994
Rbbp5
Retinoblastoma-binding protein 5 homolog; Component of the SET1 complex that specifically di- and trimethylates 'Lys-4' of histone H3 and of the MLL3/4 complex which also methylates histone H3 'Lys-4'.
   
0.992
ash2
Set1/Ash2 histone methyltransferase complex subunit ASH2; Transcriptional regulator. Regulates a number of genes involved in wing development including activation of net and bs and repression of rho and kni and controls vein-intervein patterning during wing development. Required for correct expression of a number of homeotic genes including Scr in the first leg imaginal disk and Ubx in the third leg imaginal disk and haltere disks. Required for stabilization of the histone-lysine N-methyltransferase trr and for trimethylation of 'Lys-4' of histone H3. Plays a role in maintenance of tra [...]
   
 0.992
Set1
Histone-lysine N-methyltransferase SETD1; Catalytic component of the SET1 complex that specifically di- and trimethylates 'Lys-4' of histone H3 and is the main di- and trimethyltransferase throughout development. Set1-dependent trimethylation regulates chromatin changes at active promoters that ensure optimal RNA polymerase II release into productive elongation, thereby contributing to optimal transcription.
   
 0.991
nsl1
Non-specific lethal 1, isoform M; Non-specific lethal 1 (nsl1) encodes a H4 histone acetyltransferase involved in muscle development, oogenesis and regulation of endocytosis.
   
 0.989
Dpy-30L1
Dpy-30-like 1 (Dpy-30L1) encodes a protein that is part of the COMPASS complex, a histone H3K4 methyltransferase complex thought to be responsible for the bulk of the histone H3K4 di- and trimethylation. The product of Dpy-30L1 binds to, and thereby inhibits, the metal-responsive transcription factor encoded by MTF-1.
   
 0.987
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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