node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Dpy-30L1 | Hcf | FBpp0079701 | FBpp0311451 | Dpy-30-like 1 (Dpy-30L1) encodes a protein that is part of the COMPASS complex, a histone H3K4 methyltransferase complex thought to be responsible for the bulk of the histone H3K4 di- and trimethylation. The product of Dpy-30L1 binds to, and thereby inhibits, the metal-responsive transcription factor encoded by MTF-1. | HCF C-terminal chain; May be involved in control of the cell cycle. | 0.963 |
Dpy-30L1 | Rbbp5 | FBpp0079701 | FBpp0077900 | Dpy-30-like 1 (Dpy-30L1) encodes a protein that is part of the COMPASS complex, a histone H3K4 methyltransferase complex thought to be responsible for the bulk of the histone H3K4 di- and trimethylation. The product of Dpy-30L1 binds to, and thereby inhibits, the metal-responsive transcription factor encoded by MTF-1. | Retinoblastoma-binding protein 5 homolog; Component of the SET1 complex that specifically di- and trimethylates 'Lys-4' of histone H3 and of the MLL3/4 complex which also methylates histone H3 'Lys-4'. | 0.999 |
Dpy-30L1 | Rcd5 | FBpp0079701 | FBpp0073058 | Dpy-30-like 1 (Dpy-30L1) encodes a protein that is part of the COMPASS complex, a histone H3K4 methyltransferase complex thought to be responsible for the bulk of the histone H3K4 di- and trimethylation. The product of Dpy-30L1 binds to, and thereby inhibits, the metal-responsive transcription factor encoded by MTF-1. | Reduction in Cnn dots 5 (Rcd5) encodes a protein that belongs to the family of forkhead-associated domain proteins. As part of the non-specific lethal complex, it regulates transcription of housekeeping genes by facilitating recruitment of RNA polymerase II to promoters. During mitosis it plays a key role in chromosomal-dependent microtubule assembly, centriole duplication and pericentriolar material maturation. | 0.439 |
Dpy-30L1 | Set1 | FBpp0079701 | FBpp0112593 | Dpy-30-like 1 (Dpy-30L1) encodes a protein that is part of the COMPASS complex, a histone H3K4 methyltransferase complex thought to be responsible for the bulk of the histone H3K4 di- and trimethylation. The product of Dpy-30L1 binds to, and thereby inhibits, the metal-responsive transcription factor encoded by MTF-1. | Histone-lysine N-methyltransferase SETD1; Catalytic component of the SET1 complex that specifically di- and trimethylates 'Lys-4' of histone H3 and is the main di- and trimethyltransferase throughout development. Set1-dependent trimethylation regulates chromatin changes at active promoters that ensure optimal RNA polymerase II release into productive elongation, thereby contributing to optimal transcription. | 0.996 |
Dpy-30L1 | ash2 | FBpp0079701 | FBpp0084040 | Dpy-30-like 1 (Dpy-30L1) encodes a protein that is part of the COMPASS complex, a histone H3K4 methyltransferase complex thought to be responsible for the bulk of the histone H3K4 di- and trimethylation. The product of Dpy-30L1 binds to, and thereby inhibits, the metal-responsive transcription factor encoded by MTF-1. | Set1/Ash2 histone methyltransferase complex subunit ASH2; Transcriptional regulator. Regulates a number of genes involved in wing development including activation of net and bs and repression of rho and kni and controls vein-intervein patterning during wing development. Required for correct expression of a number of homeotic genes including Scr in the first leg imaginal disk and Ubx in the third leg imaginal disk and haltere disks. Required for stabilization of the histone-lysine N-methyltransferase trr and for trimethylation of 'Lys-4' of histone H3. Plays a role in maintenance of tra [...] | 0.998 |
Dpy-30L1 | wds | FBpp0079701 | FBpp0300790 | Dpy-30-like 1 (Dpy-30L1) encodes a protein that is part of the COMPASS complex, a histone H3K4 methyltransferase complex thought to be responsible for the bulk of the histone H3K4 di- and trimethylation. The product of Dpy-30L1 binds to, and thereby inhibits, the metal-responsive transcription factor encoded by MTF-1. | Protein will die slowly; Contributes to histone modification. May position the N- terminus of histone H3 for efficient trimethylation at 'Lys-4'. | 0.987 |
Hcf | Dpy-30L1 | FBpp0311451 | FBpp0079701 | HCF C-terminal chain; May be involved in control of the cell cycle. | Dpy-30-like 1 (Dpy-30L1) encodes a protein that is part of the COMPASS complex, a histone H3K4 methyltransferase complex thought to be responsible for the bulk of the histone H3K4 di- and trimethylation. The product of Dpy-30L1 binds to, and thereby inhibits, the metal-responsive transcription factor encoded by MTF-1. | 0.963 |
Hcf | MBD-R2 | FBpp0311451 | FBpp0082081 | HCF C-terminal chain; May be involved in control of the cell cycle. | MBD-R2 (MBD-R2) encodes a Zinc finger C2H2 transcription factor. It is a component of nonspecific lethal (NSL) complex involved in transcriptional activation. | 0.655 |
Hcf | Rbbp5 | FBpp0311451 | FBpp0077900 | HCF C-terminal chain; May be involved in control of the cell cycle. | Retinoblastoma-binding protein 5 homolog; Component of the SET1 complex that specifically di- and trimethylates 'Lys-4' of histone H3 and of the MLL3/4 complex which also methylates histone H3 'Lys-4'. | 0.986 |
Hcf | Rcd1 | FBpp0311451 | FBpp0302789 | HCF C-terminal chain; May be involved in control of the cell cycle. | Reduction in Cnn dots 1 (Rcd1) encodes a protein involved in centriole replication and transcription regulation. | 0.715 |
Hcf | Rcd5 | FBpp0311451 | FBpp0073058 | HCF C-terminal chain; May be involved in control of the cell cycle. | Reduction in Cnn dots 5 (Rcd5) encodes a protein that belongs to the family of forkhead-associated domain proteins. As part of the non-specific lethal complex, it regulates transcription of housekeeping genes by facilitating recruitment of RNA polymerase II to promoters. During mitosis it plays a key role in chromosomal-dependent microtubule assembly, centriole duplication and pericentriolar material maturation. | 0.825 |
Hcf | Set1 | FBpp0311451 | FBpp0112593 | HCF C-terminal chain; May be involved in control of the cell cycle. | Histone-lysine N-methyltransferase SETD1; Catalytic component of the SET1 complex that specifically di- and trimethylates 'Lys-4' of histone H3 and is the main di- and trimethyltransferase throughout development. Set1-dependent trimethylation regulates chromatin changes at active promoters that ensure optimal RNA polymerase II release into productive elongation, thereby contributing to optimal transcription. | 0.988 |
Hcf | ash2 | FBpp0311451 | FBpp0084040 | HCF C-terminal chain; May be involved in control of the cell cycle. | Set1/Ash2 histone methyltransferase complex subunit ASH2; Transcriptional regulator. Regulates a number of genes involved in wing development including activation of net and bs and repression of rho and kni and controls vein-intervein patterning during wing development. Required for correct expression of a number of homeotic genes including Scr in the first leg imaginal disk and Ubx in the third leg imaginal disk and haltere disks. Required for stabilization of the histone-lysine N-methyltransferase trr and for trimethylation of 'Lys-4' of histone H3. Plays a role in maintenance of tra [...] | 0.993 |
Hcf | dgt1 | FBpp0311451 | FBpp0308967 | HCF C-terminal chain; May be involved in control of the cell cycle. | Dim gamma-tubulin 1, isoform C; Histone acetyltransferase activity (H4-K16 specific); histone acetyltransferase activity (H4-K8 specific); histone acetyltransferase activity (H4-K5 specific). It is involved in the biological process described with: histone H4-K16 acetylation; histone H4-K8 acetylation; histone H4-K5 acetylation. | 0.517 |
Hcf | wds | FBpp0311451 | FBpp0300790 | HCF C-terminal chain; May be involved in control of the cell cycle. | Protein will die slowly; Contributes to histone modification. May position the N- terminus of histone H3 for efficient trimethylation at 'Lys-4'. | 0.996 |
MBD-R2 | Hcf | FBpp0082081 | FBpp0311451 | MBD-R2 (MBD-R2) encodes a Zinc finger C2H2 transcription factor. It is a component of nonspecific lethal (NSL) complex involved in transcriptional activation. | HCF C-terminal chain; May be involved in control of the cell cycle. | 0.655 |
MBD-R2 | Rcd1 | FBpp0082081 | FBpp0302789 | MBD-R2 (MBD-R2) encodes a Zinc finger C2H2 transcription factor. It is a component of nonspecific lethal (NSL) complex involved in transcriptional activation. | Reduction in Cnn dots 1 (Rcd1) encodes a protein involved in centriole replication and transcription regulation. | 0.999 |
MBD-R2 | Rcd5 | FBpp0082081 | FBpp0073058 | MBD-R2 (MBD-R2) encodes a Zinc finger C2H2 transcription factor. It is a component of nonspecific lethal (NSL) complex involved in transcriptional activation. | Reduction in Cnn dots 5 (Rcd5) encodes a protein that belongs to the family of forkhead-associated domain proteins. As part of the non-specific lethal complex, it regulates transcription of housekeeping genes by facilitating recruitment of RNA polymerase II to promoters. During mitosis it plays a key role in chromosomal-dependent microtubule assembly, centriole duplication and pericentriolar material maturation. | 0.999 |
MBD-R2 | Set1 | FBpp0082081 | FBpp0112593 | MBD-R2 (MBD-R2) encodes a Zinc finger C2H2 transcription factor. It is a component of nonspecific lethal (NSL) complex involved in transcriptional activation. | Histone-lysine N-methyltransferase SETD1; Catalytic component of the SET1 complex that specifically di- and trimethylates 'Lys-4' of histone H3 and is the main di- and trimethyltransferase throughout development. Set1-dependent trimethylation regulates chromatin changes at active promoters that ensure optimal RNA polymerase II release into productive elongation, thereby contributing to optimal transcription. | 0.678 |
MBD-R2 | dgt1 | FBpp0082081 | FBpp0308967 | MBD-R2 (MBD-R2) encodes a Zinc finger C2H2 transcription factor. It is a component of nonspecific lethal (NSL) complex involved in transcriptional activation. | Dim gamma-tubulin 1, isoform C; Histone acetyltransferase activity (H4-K16 specific); histone acetyltransferase activity (H4-K8 specific); histone acetyltransferase activity (H4-K5 specific). It is involved in the biological process described with: histone H4-K16 acetylation; histone H4-K8 acetylation; histone H4-K5 acetylation. | 0.996 |