STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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Textmining
[Homology]
Score
Mlc-cMyosin light chain cytoplasmic (Mlc-c) encodes a subunit of the myosin complex that is involved in actin filament-based movement. (153 aa)    
Predicted Functional Partners:
sqh
Spaghetti squash (sqh) encodes the regulatory light chain of the nonmuscle type 2 myosin. Its phosphorylation through the Rho-Rho Kinase pathway is predicted to activate myosin motor activity. The product of sqh and myosin function in cellular processes such as cytokinesis, and also contribute to tissue morphogenesis.
   
0.962
zip
Myosin heavy chain, non-muscle; Nonmuscle myosin appears to be responsible for cellularization. Required for morphogenesis and cytokinesis. Necessary for auditory transduction: plays a role in Johnston's organ organization by acting in scolopidial apical attachment. Interaction with the myosin ck may be important for this function. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
   
 0.959
didum
Dilute class unconventional myosin (didum) encodes a class V unconventional myosin that binds actin and hydrolyzes ATP. It functions in mRNA localization in the oocyte, spermatid individualization during spermatogenesis, transport of pigment granules in photoreceptors and mitochondrial transport in neuronal cells; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
    
 0.946
Mlc2
Myosin light chain 2 (Mlc2) encodes a subunit of the myosin complex involved in myofibril assembly. It contributes to different flight-related processes including wing beat frequency, and indirect flight muscle contraction.
  
 0.883
CG33098
MIP03207p; Calcium ion binding.
  
 0.853
jar
Myosin heavy chain 95F; Myosin is a protein that binds to actin and has ATPase activity that is activated by actin. Together CLIP-190 and jar may coordinate the interaction between the actin and microtubule cytoskeleton. May link endocytic vesicles to microtubules and may be involved in transport in the early embryo and in the dynamic process of dorsal closure. It is believed that its function changes during the life cycle.
   
  0.828
ck
Myosin-VIIa; Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements: can function in cells as a single-molecule cargo transporter. A very slow and high-duty-ratio motor, may be suitable for tension maintenance of actin filaments. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments. Plays a key role in the formation of cellular projections and other actin-based functions required for embryonic and larval viability. Necessary for auditory transduction: [...]
    
 0.822
Mhc
Myosin heavy chain (Mhc) encodes the motor protein that provides the force for muscle contraction through its ATP-dependent interaction with actin filaments. It functions with essential and regulatory light chains.
   
 0.798
Mhcl
Myosin heavy chain-like, isoform B; Myosin heavy chain-like (Mhcl) encodes a protein that interacts with the product of rols during myoblast fusion; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
   
 0.792
Mlc1
Myosin light chain alkali; Microfilament motor activity; calcium ion binding. It is involved in the biological process described with: muscle contraction; mesoderm development.
  
 
0.789
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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